Abstract:
:In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practicing other HIV-risk behaviors. Patients with KS in Sub-Saharan Africa have very high tumor burdens and rapid disease progression with a diminished life expectancy of less than 6 months. KS lesions are comprised of both distinctive spindle cells of endothelial origin and a variable inflammatory infiltrate, which suggests that KS may result from reactive hyperproliferation induced by chronic inflammation, and therefore it is not a true neoplasm. KS has a variable clinical course ranging from very indolent forms, requiring no or minimal therapy, to a rapidly progressive disease. Treatment decisions must take into consideration the extent and the rate of tumor growth, patient's symptoms, immune system conditions and concurrent HIV-related complications. Several different therapeutic options are available but the optimal therapy is still unclear. Highly Active Antiretroviral Therapy (HAART) including protease inhibitors (PI) may represent the first treatment step for slowly progressive disease; chemotherapy (CT) plus HAART is indicated for visceral and/or rapidly progressive disease, whereas maintenance (M)-HAART after systemic chemotherapy may be an effective anti-KS measure after debulking CT. The angiogenic nature of KS makes it particularly suitable for therapies based on targeted agents such as metalloproteinase inhibitors, angiogenesis inhibitors and tyrosine kinase inhibitors. The aim of this article is to provide an up-to-date review of the current status and perspectives of AIDS-related KS in the HAART era.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Martellotta F,Berretta M,Vaccher E,Schioppa O,Zanet E,Tirelli Udoi
10.2174/157016209789973619subject
Has Abstractpub_date
2009-11-01 00:00:00pages
634-8issue
6eissn
1570-162Xissn
1873-4251journal_volume
7pub_type
杂志文章,评审abstract::HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective combined anti-retroviral therapy (cART). Cognitive function has been shown to inversely correlate with decreased synaptic and dendritic density. In this study, macaques inoculated with SIV were examined over a 3-month course of infection...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1131100049
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190506155222
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journal_title:Current HIV research
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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journal_title:Current HIV research
pub_type: 杂志文章
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journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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journal_title:Current HIV research
pub_type: 杂志文章
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journal_title:Current HIV research
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journal_title:Current HIV research
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206778560009
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666170517130339
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes. OBJECTIVE:To improve the meth...
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pub_type: 杂志文章
doi:10.2174/1570162X17666190306125819
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2011-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209788680561
更新日期:2009-07-01 00:00:00
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pub_type: 临床试验
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更新日期:2020-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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