Abstract:
:Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surface CD4 regulation constitutes an important determinant of viral replication and pathogenesis in vivo. This review highlights recent progress made in our understanding of the molecular mechanisms underlying the down-regulation of the CD4 receptor by HIV-1 and describes our current comprehension of the role of CD4 down-regulation during HIV-1 infection.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Levesque K,Finzi A,Binette J,Cohen EAdoi
10.2174/1570162043485086keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
51-9issue
1eissn
1570-162Xissn
1873-4251journal_volume
2pub_type
杂志文章,评审abstract::The oral cavity of human immunodeficiency virus type I (HIV-1) infected individuals is subjected to a series of opportunistic infections which are usually considered as a prognostic marker for the severity of infection as well as an indicator of immunodeficiency. The highly active antiretroviral therapy (HAART) has si...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207780636533
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining metho...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1205141121102501
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Tolerability, long-term toxicities and selection of resistant variants limit the use and efficacy of antiretroviral drugs in HIV-positive patients. Novel combinations are needed for mantaining long-term control of HIV replication; nevertheless scarse data are available on protease inhibitor-free dual antiret...
journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
doi:10.2174/1570162x13666150929112135
更新日期:2016-01-01 00:00:00
abstract::Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666191231105438
更新日期:2020-01-01 00:00:00
abstract::AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207781023965
更新日期:2007-07-01 00:00:00
abstract::A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207782418470
更新日期:2007-11-01 00:00:00
abstract::Most new HIV infections in sub-Saharan Africa now occur in married and cohabiting couples, many of whom do not realize that only one of them may be infected with HIV. HIV-negative individuals living in stable HIV-discordant partnerships (in which one partner is HIV-infected while the other one is not) are twice as lik...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210793499303
更新日期:2010-09-01 00:00:00
abstract::Premature immunosenescence has been reported in different HIV scenarios. However, how premature is the HIV-related immunosenescent phenotype is still unknown. Thus, the aim of this study was to analyze the immunosenescent status of young viraemic naive HIV-infected individuals, with less than four years from infection...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211797636008
更新日期:2011-07-01 00:00:00
abstract::A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210794088290
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART), especially with tenofovir disoproxil fumarate (TDF), has been associated with accelerated bone turnover and leads to significant bone loss. OBJECTIVE:We aimed to determine the effect of vitamin D2 and calcium on bone mineral density (BMD) in HIV-infected patients receiving TDF/...
journal_title:Current HIV research
pub_type: 临床试验
doi:10.2174/1570162X18666200106150806
更新日期:2020-01-01 00:00:00
abstract::Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute t...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162x113116660060
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789973637
更新日期:2009-11-01 00:00:00
abstract::Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviors. The intersection, of the twin epidemics of HIV and drug/alcohol use, results in difficult medical management issues for the health care...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209788680598
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190809153245
更新日期:2019-01-01 00:00:00
abstract::The present study assessed the phenotypic aspects of oral-cavity Candida albicans isolates from 300 HIV-1- positive patients, relating the most commonly investigated virulence factors (enzyme typing and germ-tube formation) to the most common morphotypes. The samples were seeded into specific media for isolation and s...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990042
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apoli...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666181018155827
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210791111098
更新日期:2010-04-01 00:00:00
abstract::Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211798998736
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x14666160401131426
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666170511141741
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Identifying the genetic variability in vertically transmitted viruses in early infancy is important to understand the disease progression. Being important in HIV-1 disease pathogenesis, vpu gene, isolated from young infants was investigated to understand the viral characteristics. METHOD:Blood samples were o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666180219154601
更新日期:2018-01-01 00:00:00
abstract::VGV-1, a clinical-grade formulation of bovine thymus nuclear protein (TNP) has been demonstrated to possess anti-viral activity in HIV-1 patients in five clinical trials, one of which was placebo controlled double-blinded. However, to date molecular mechanisms remain to be identified. Using surface plasmon resonance w...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208785132545
更新日期:2008-06-01 00:00:00
abstract::Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV ...
journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
doi:10.2174/157016208784325010
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016207781662434
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:The diversity of the HIV proteome influences the cellular response and development of an effective vaccine, particularly due to the generation of viral variants with mutations located within CD8+ T-cell epitopes. These mutations can affect the recognition of the epitopes, that may result in the selection of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191017105910
更新日期:2019-01-01 00:00:00
abstract::While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210793499169
更新日期:2010-10-01 00:00:00
abstract::The cellular protein "Bone marrow stromal antigen 2" (BST2 also called Tetherin, CD317, HM1.24) was identified as a major mediator of the innate immune defense against the dissemination of enveloped viruses. BST2 was shown to physically trap the de novo formed viral particles at the surface of infected cells, thereby ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800792414
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending ou...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206776055075
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200712173630
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes. OBJECTIVE:To improve the meth...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190306125819
更新日期:2018-01-01 00:00:00