Prevalence of and Risk Factors for Low Free Testosterone Levels in Japanese Men with Well-controlled Human Immunodeficiency Virus Infection.

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...

journal_title：Current HIV research

authors： Loonam CR,O'Dell SD,Sharp PA,Mullen A

更新日期：2016-01-01 00:00:00

abstract：:In HIV-1 infected cells, over 40 different mRNA species are produced by alternative splicing of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 primary RNA transcripts are not spliced and are exported to the cytoplasm where they serve as mRNA and as genomic RNA. In this article, w...

journal_title：Current HIV research

authors： Stoltzfus CM,Madsen JM

更新日期：2006-01-01 00:00:00

abstract：:While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

journal_title：Current HIV research

authors： Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

更新日期：2010-10-01 00:00:00

abstract：:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...

journal_title：Current HIV research

authors： Jarvis GA,Chang TL

更新日期：2012-04-01 00:00:00

abstract：:Previous studies have demonstrated that nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) act as chemical enhancers of human immunodeficiency virus type 1 (HIV-1) RT dimerization. In the current study, we sought to define the role of key residues (101, 103, 108, 181, 188, 190, 225 and 318) in the NNRTI-bind...

journal_title：Current HIV research

authors： Figueiredo A,Zelina S,Sluis-Cremer N,Tachedjian G

更新日期：2008-03-01 00:00:00

abstract：:The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...

journal_title：Current HIV research

authors： Pitisuttithum P

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...

journal_title：Current HIV research

authors： Digban TO,Iweriebor BC,Obi LC,Nwodo U,Okoh AI

更新日期：2019-01-01 00:00:00

abstract：:Beta defensins are antimicrobial peptides that serve to protect the host from microbial invasion at skin and mucosal surfaces. Here we explore the relationships among beta defensin levels, total bacterial colonization, and colonization by bacterial vaginosis (BV)-related bacteria and lactobacilli in the female genital...

journal_title：Current HIV research

authors： Jiang W,Ghosh SK,Flyckt R,Kalinowska M,Starks D,Jurevic R,Weinberg A,Lederman MM,Rodriguez B

更新日期：2012-09-01 00:00:00

abstract：:The oral cavity of human immunodeficiency virus type I (HIV-1) infected individuals is subjected to a series of opportunistic infections which are usually considered as a prognostic marker for the severity of infection as well as an indicator of immunodeficiency. The highly active antiretroviral therapy (HAART) has si...

journal_title：Current HIV research

authors： Parveen Z,Acheampong E,Pomerantz RJ,Jacobson JM,Wigdahl B,Mukhtar M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:HIV-1+ long-term nonprogressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS:We evaluated the plasma levels of IP-10/IL-8 chemokines...

journal_title：Current HIV research

authors： Dos Santos JS,de Almeida SM,Ferreira GS,Bordignon J,Maia Teixeira SL,Martins Lima AC,Raboni SM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...

journal_title：Current HIV research

authors： Jaiswal J,Griffin M,Singer SN,Greene RE,Acosta ILZ,Kaudeyr SK,Kapadia F,Halkitis PN

更新日期：2018-01-01 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes. OBJECTIVE:To improve the meth...

journal_title：Current HIV research

authors： Rodriguez J,Prieto S,Correa C,Melo M,Dominguez D,Olarte N,Suárez D,Aragón L,Torres F,Santacruz F

更新日期：2018-01-01 00:00:00

abstract：:AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...

journal_title：Current HIV research

authors： Zeinalipour-Loizidou E,Nicolaou C,Nicolaides A,Kostrikis LG

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...

journal_title：Current HIV research

authors： Erdinc FS,Dokuzoguz B,Unal S,Komur S,Inkaya AC,Inan D,Karaoglan I,Deveci A,Celen MK,Kose S,Erben N,Senturk GC,Heper Y,Kutlu SS,Hatipoglu CA,Sumer S,Kandemir B,Sirmatel F,Bayindir Y,Yilmaz E,Ersoy Y,Kazak E,Yil

更新日期：2020-01-01 00:00:00

abstract：:A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...

journal_title：Current HIV research

authors： Lu S,Grimes Serrano JM,Wang S

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

journal_title：Current HIV research

authors： Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

更新日期：2017-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) is unique in its capacity to produce chronic disease in almost all infected hosts. To accomplish this, it has evolved multiple mechanisms to effectively evade the immune response. HIV encodes at least one protein that makes infected cells resistant to CTL killing by downmodulatin...

journal_title：Current HIV research

authors： Collins KL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Despite intense efforts, AIDS is difficult to tackle by current anti-retroviral therapy (ART) due to its side effects; therefore, there is an urgent need to discover potential, multitarget and low-cost anti-HIV compounds. OBJECTIVE:We have shown that few phytocompounds can potentially inhibit the prime targ...

journal_title：Current HIV research

authors： Vora J,Athar M,Sinha S,Jha PC,Shrivastava N

更新日期：2020-01-01 00:00:00

abstract：:Immunization is an important measure to protect HIV-infected children and adults against certain vaccine preventable diseases. However, the antibody response, which is associated with the level of CD4+ T cell count, is frequently impaired in this group of patients. Certain vaccines enhance virus replication and transi...

journal_title：Current HIV research

authors： Pancharoen C,Ananworanich J,Thisyakorn U

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. OBJECTIVE:Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we desig...

journal_title：Current HIV research

authors： Safakish M,Hajimahdi Z,Aghasadeghi MR,Vahabpour R,Zarghi A

更新日期：2020-01-01 00:00:00

abstract：:Most new HIV infections in sub-Saharan Africa now occur in married and cohabiting couples, many of whom do not realize that only one of them may be infected with HIV. HIV-negative individuals living in stable HIV-discordant partnerships (in which one partner is HIV-infected while the other one is not) are twice as lik...

journal_title：Current HIV research

authors： Matovu JK

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...

journal_title：Current HIV research

authors： Sagay AS,Ebonyi AO,Meloni ST,Musa J,Oguche S,Ekwempu CC,Oyebode T,Ejeliogu E,Imade GE,Agbaji OO,Okonkwo P,Kanki PJ

更新日期：2015-01-01 00:00:00

abstract：:According to the World Health Organization's 2007 estimates, close to 33 million people worldwide are living with HIV/AIDS. Over the past two decades, significant progress has been made in understanding HIV pathogenesis and disease progression, which has allowed the identification of a multitude of drug and vaccine ta...

journal_title：Current HIV research

authors： Endsley AN,Salama NN,Ho RJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Many HIV research projects are plagued by the high missing rate of selfreported information during data collection. Also, due to the sensitive nature of the HIV research data, privacy protection is always a concern for data sharing in HIV studies. METHODS:This paper applies a data masking approach, called t...

journal_title：Current HIV research

authors： Pei Q,Chen S,Xiao Y,Wu SS

更新日期：2016-01-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：:Antiretroviral drug therapy has significantly improved the prognosis and life expectancy of people living with HIV over the years. But this progress comes with an important caveat that antiretroviral regimens generally require adherence to life-long, daily dosing, to keep viral multiplication under check. Non-adherenc...

journal_title：Current HIV research

authors： Labh R,Gupta R

更新日期：2020-08-23 00:00:00

abstract：:After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR ...

journal_title：Current HIV research

authors： Beloukas A,Paraskevis D,Psichogiou M,Hatzakis A

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Although HIV and injury contribute substantially to disease burdens in lowand middle-income countries (LMIC), their intersection is poorly characterized. OBJECTIVE:This systematic review assessed the prevalence and associated mortality impact of HIVseropositivity among injured patients in LMIC. METHODS:A s...

journal_title：Current HIV research

authors： Aluisio AR,Rege S,Stewart BT,Kinuthia J,Levine AC,Mello MJ,Farquhar C

更新日期：2017-11-23 00:00:00