Abstract:
BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 among the anti-retroviral therapy (ART) exposed HIV-1 infected individuals of Manipur was conducted. METHODS:110 HIV-1 positive individuals who had initially exposed to first line anti-HIV drugs were recruited for the surveillance of DRAMs. Reverse transcriptase and protease genes of HIV-1 were amplified, sequenced and analyzed. RESULTS:Significant prevalence of DRAMs of HIV-1 was found among the ART exposed HIV-1 infected individuals of Manipur. The results revealed that 37%, 29% and 7% individuals harbor HIV-1 strains mutated at the target sites of nonnucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors and protease inhibitors respectively. Predominant DRAMs at RT genes were M184V, T215Y, M41L and V108I and H221Y while at PR genes were M46I and I47V. Among the high risk groups, intravenous drug users have the highest number of DRAMs followed by heterosexual individuals. Analysis of viral subtype based on pol gene revealed 83% subtype C, 11.8% recombinant forms and 5.2% subtype B. CONCLUSION:DRAMs at the target sites of reverse transcriptase inhibitors are high and these were found to have developed resistance to the primary ART drugs that are used in Manipur. The findings of this study will help the clinicians to guide patients during the course of ART treatment regimes.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Lakhikumar Sharma A,Ramsing Singh T,Ranjana Devi K,Shanjukumar Singh Ldoi
10.2174/1570162x14666160401131426subject
Has Abstractpub_date
2016-01-01 00:00:00pages
360-70issue
4eissn
1570-162Xissn
1873-4251pii
CHR-EPUB-74731journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE:To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in ...
journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
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doi:10.2174/1570162x1131100049
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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