Applying Triple-Matrix Masking for Privacy Preserving Data Collection and Sharing in HIV Studies.


BACKGROUND:Many HIV research projects are plagued by the high missing rate of selfreported information during data collection. Also, due to the sensitive nature of the HIV research data, privacy protection is always a concern for data sharing in HIV studies. METHODS:This paper applies a data masking approach, called triple-matrix masking [1], to the context of HIV research for ensuring privacy protection during the process of data collection and data sharing. RESULTS:Using a set of generated HIV patient data, we show step by step how the data are randomly transformed (masked) before leaving the patients' individual data collection device (which ensures that nobody sees the actual data) and how the masked data are further transformed by a masking service provider and a data collector. We demonstrate that the masked data retain statistical utility of the original data, yielding the exactly same inference results in the planned logistic regression on the effect of age on the adherence to antiretroviral therapy and in the Cox proportional hazard model for the age effect on time to viral load suppression. CONCLUSION:Privacy-preserving data collection method may help resolve the privacy protection issue in HIV research. The individual sensitive data can be completely hidden while the same inference results can still be obtained from the masked data, with the use of common statistical analysis methods.


Curr HIV Res


Current HIV research


Pei Q,Chen S,Xiao Y,Wu SS




Has Abstract


2016-01-01 00:00:00














  • Epidemiological profile of naive HIV-1/AIDS patients in Istanbul: the largest case series from Turkey.

    abstract::The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Yemisen M,Aydın OA,Gunduz A,Ozgunes N,Mete B,Ceylan B,Karaosmanoglu HK,Yildiz D,Sargin F,Ozaras R,Tabak F

    更新日期:2014-01-01 00:00:00

  • Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects.

    abstract::Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Jarvis GA,Chang TL

    更新日期:2012-04-01 00:00:00

  • HLA-C Single Nucleotide Polymorphism Associated with Increased Viral Load Level in HIV-1 Infected Individuals from Northeast Brazil.

    abstract:BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

    更新日期:2017-01-01 00:00:00

  • Antiviral Activity of Fecal Water Samples from HIV-1 Infected Subjects Treated with a Specific Probiotic Formulation.

    abstract:OBJECTIVES:The aim of the study was to investigate if the supplementation with multistrain probiotics may be able to modulate T cell response in HIV-1 infected patients and to evaluate the anti-HIV activity of probiotic by studying fecal water (FW) samples. METHODS:Three HIV-1-positive patients (Pt1, Pt2 and Pt3) on l...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Falasca F,Cavallari EN,Innocenti GP,Scagnolari C,Mezzaroma I,Santinelli L,Ceccarelli G,Vullo V,Turriziani O,d'Ettorre G

    更新日期:2019-01-01 00:00:00

  • Structural Barriers to Pre-exposure Prophylaxis Use Among Young Sexual Minority Men: The P18 Cohort Study.

    abstract:BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Jaiswal J,Griffin M,Singer SN,Greene RE,Acosta ILZ,Kaudeyr SK,Kapadia F,Halkitis PN

    更新日期:2018-01-01 00:00:00

  • Polyfunctional CD8+ T-Cell Response to Autologous Peptides from Protease and Reverse Transcriptase of HIV-1 Clade B.

    abstract:BACKGROUND:The diversity of the HIV proteome influences the cellular response and development of an effective vaccine, particularly due to the generation of viral variants with mutations located within CD8+ T-cell epitopes. These mutations can affect the recognition of the epitopes, that may result in the selection of ...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Acevedo-Saenz L,Perdomo-Celis F,Montoya CJ,Velilla PA

    更新日期:2019-01-01 00:00:00

  • HIV-1 residual viremia and proviral DNA in patients with suppressed plasma viral load (

    abstract::Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV ...

    journal_title:Current HIV research

    pub_type: 杂志文章,多中心研究


    authors: Nicastri E,Palmisano L,Sarmati L,D'Ettorre G,Parisi S,Andreotti M,Buonomini A,Pirillo FM,Narciso P,Bellagamba R,Vullo V,Montano M,Di Perri G,Andreoni M

    更新日期:2008-05-01 00:00:00

  • Combining drug and immune therapy: a potential solution to drug resistance and challenges of HIV vaccines?

    abstract::According to the World Health Organization's 2007 estimates, close to 33 million people worldwide are living with HIV/AIDS. Over the past two decades, significant progress has been made in understanding HIV pathogenesis and disease progression, which has allowed the identification of a multitude of drug and vaccine ta...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Endsley AN,Salama NN,Ho RJ

    更新日期:2008-09-01 00:00:00

  • Polymorphic receptors of the innate immune system (MBL/MASP-2 and TLR2/4) and susceptibility to pneumococcal bacteremia in HIV-infected patients: a case-control study.

    abstract:UNLABELLED:Some deficient genetic polymorphisms of the innate immune system have been correlated to a higher susceptibility to different infections, especially in immunocompromised patients. The possible association between an increased incidence of pneumococcal bacteremia in HIV-infected patients, and deficient polymo...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Horcajada JP,Lozano F,Muñoz A,Suarez B,Fariñas-Alvarez C,Almela M,Smithson A,Martínez E,Mallolas J,Mensa J,Gatell JM

    更新日期:2009-03-01 00:00:00

  • Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort.

    abstract::Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Limou S,Melica G,Coulonges C,Lelièvre JD,Do H,McGinn S,Gut IG,Lévy Y,Zagury JF

    更新日期:2012-03-01 00:00:00

  • Potential Role of Regulatory T Cells in Mother-to-Child Transmission of HIV.

    abstract:BACKGROUND:Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Kessler PA

    更新日期:2018-01-01 00:00:00

  • Role of CD4 receptor down-regulation during HIV-1 infection.

    abstract::Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surfa...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Levesque K,Finzi A,Binette J,Cohen EA

    更新日期:2004-01-01 00:00:00

  • Mother-to-Child Transmission Outcomes of HIV-Exposed Infants Followed Up in Jos North-Central Nigeria.

    abstract:OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Sagay AS,Ebonyi AO,Meloni ST,Musa J,Oguche S,Ekwempu CC,Oyebode T,Ejeliogu E,Imade GE,Agbaji OO,Okonkwo P,Kanki PJ

    更新日期:2015-01-01 00:00:00

  • Mechanisms of HIV-1 neurotropism.

    abstract::Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS and frequently causes neurocognitive impairment. Although antiviral therapy generally reduces the viral load in the CNS and improves HIV-associated neurological dysfunction, most current antiviral drugs have poor CNS penetrance and ...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Dunfee R,Thomas ER,Gorry PR,Wang J,Ancuta P,Gabuzda D

    更新日期:2006-07-01 00:00:00

  • Identification of cross-neutralization determinants by GAP analysis: a mutational behavior approach.

    abstract::Antigenic variation, which is the result of amino acid substitution and genetic evolution, poses a major challenge in the development of vaccines against pathogens with unstable genomes, such as HIV-1 and Influenza. Thus, it is highly important to characterize the relationship of genetic evolution, antigenic variation...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Li F,Gilbert PB,Self SG

    更新日期:2007-01-01 00:00:00

  • A study of tryptophan metabolism via serotonin in ventricular cerebrospinal fluid in HIV-1 infection using a neuroendoscopic technique.

    abstract::In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. Th...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Longatti P,Perin A,Comai S,Bertazzo A,Rizzo V,Costa CV,Allegri G

    更新日期:2007-03-01 00:00:00

  • Raltegravir Plus Nevirapine as Maintenance Antiretroviral Therapy in HIV-Positive Patients: Safety, Efficacy and Pharmacokinetics.

    abstract:BACKGROUND:Tolerability, long-term toxicities and selection of resistant variants limit the use and efficacy of antiretroviral drugs in HIV-positive patients. Novel combinations are needed for mantaining long-term control of HIV replication; nevertheless scarse data are available on protease inhibitor-free dual antiret...

    journal_title:Current HIV research

    pub_type: 杂志文章,多中心研究


    authors: Calcagno A,Montrucchio C,Capetti A,Guaraldi G,Cenderello G,Calza L,Lanzafame M,Marinaro L,Tettoni MC,Trentini L,D'Avolio A,Di Perri G,Bonora S

    更新日期:2016-01-01 00:00:00

  • Efficacy, tolerability and virological consequences of long-term use of unboosted atazanavir plus 2 NRTIs in HIV-infected patients.

    abstract:PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

    更新日期:2014-01-01 00:00:00

  • Genotypic Methods for HIV Drug Resistance Monitoring: The Opportunities and Challenges Faced by China.

    abstract::AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Zuo L,Peng K,Hu Y,Xu Q

    更新日期:2019-01-01 00:00:00

  • Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.

    abstract::Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Rausch JW,Le Grice SFJ

    更新日期:2020-01-01 00:00:00

  • What impact might the economic crisis have on HIV epidemics in Southeast Asia?

    abstract:OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Gray RT,Heymer KJ,Hoare A,Kwon JA,Thein HH,Lote N,Siba P,Saramony S,Saphonn V,Worth H,Kaldor JM,Wilson DP

    更新日期:2009-11-01 00:00:00

  • 14-3-3 Protein in CSF reflects SIV-mediated pre-synaptic damage.

    abstract::HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective combined anti-retroviral therapy (cART). Cognitive function has been shown to inversely correlate with decreased synaptic and dendritic density. In this study, macaques inoculated with SIV were examined over a 3-month course of infection...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Helke KL,Queen SE,Mankowski JL

    更新日期:2013-06-01 00:00:00

  • The role of HIV-1 DNA as an additional marker of HIV-1 infection.

    abstract::After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR ...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Beloukas A,Paraskevis D,Psichogiou M,Hatzakis A

    更新日期:2009-05-01 00:00:00

  • Plasma Membrane Proteomic Profile Discovers Macrophage-capping Protein Related to Latent HIV-1.

    abstract:BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Zhang Y,Shen Y,Yin L,Qi T,Jia X,Lu H,Zhang L

    更新日期:2019-01-01 00:00:00

  • CD8+ cell noncytotoxic antiviral response in long-term HIV-1 infected former blood donors in China.

    abstract::Most of the HIV-infected long term survivors show strong CD8+ cell noncytotoxic antiviral response (CNAR) that plays as an important factor for maintaining the relative healthy state of infected individuals. HIV infected former blood donors (FBDs) in Anhui, China are the unique population that considered infected by t...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Yuan L,Ma L,Fan X,Feng Y,Peng H,Zhao Q,Ruan Y,Levy JA,Shao Y

    更新日期:2009-07-01 00:00:00

  • Structural bases of the annealing of primer tRNA(3Lys) to the HIV-1 viral RNA.

    abstract::To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Tisné C

    更新日期:2005-04-01 00:00:00

  • Detection of the active components of calf thymus nuclear proteins (TNP), histones that are binding with high affinity to HIV-1 envelope proteins and CD4 molecules.

    abstract::VGV-1, a clinical-grade formulation of bovine thymus nuclear protein (TNP) has been demonstrated to possess anti-viral activity in HIV-1 patients in five clinical trials, one of which was placebo controlled double-blinded. However, to date molecular mechanisms remain to be identified. Using surface plasmon resonance w...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Mamikonyan G,Kiyatkin A,Movsesyan N,Mkrtichyan M,Ghochikyan A,Petrushina I,Hwang J,Ichim TE,Keledjian H,Agadjanyan MG

    更新日期:2008-06-01 00:00:00

  • Emerging Trends in the Long-acting Antiretroviral Therapy: Current Status and Therapeutic Challenges.

    abstract::Antiretroviral drug therapy has significantly improved the prognosis and life expectancy of people living with HIV over the years. But this progress comes with an important caveat that antiretroviral regimens generally require adherence to life-long, daily dosing, to keep viral multiplication under check. Non-adherenc...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Labh R,Gupta R

    更新日期:2020-08-23 00:00:00

  • Activation of the RNA-dependent protein kinase (PKR) of lymphocytes by regulatory RNAs: implications for immunomodulation in HIV infection.

    abstract::It has been known for decades that exogenous RNAs are able to induce cytotoxic T lymphocytes (CTLs) and immunological reactivity to a wide variety of antigens. The molecular events responsible for these effects remain unclear for more than two decades. It has been decided to revisit this phenomenon in the light of new...

    journal_title:Current HIV research

    pub_type: 杂志文章,评审


    authors: Watanabe MA,de Souza LR,Murad JM,De Lucca FL

    更新日期:2005-10-01 00:00:00

  • Profile of HIV-1 infected patients from an AIDS clinic in Beijing from 2007-2008.

    abstract::While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

    journal_title:Current HIV research

    pub_type: 杂志文章


    authors: Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

    更新日期:2010-10-01 00:00:00