Bacterial colonization and beta defensins in the female genital tract in HIV infection.

abstract：:Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...

journal_title：Current HIV research

authors： Rausch JW,Le Grice SFJ

更新日期：2020-01-01 00:00:00

abstract：:It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...

journal_title：Current HIV research

authors： Tozzi V,Libertone R,Liuzzi G

更新日期：2008-11-01 00:00:00

abstract：:Most new HIV infections in sub-Saharan Africa now occur in married and cohabiting couples, many of whom do not realize that only one of them may be infected with HIV. HIV-negative individuals living in stable HIV-discordant partnerships (in which one partner is HIV-infected while the other one is not) are twice as lik...

journal_title：Current HIV research

authors： Matovu JK

更新日期：2010-09-01 00:00:00

abstract：:VGV-1, a clinical-grade formulation of bovine thymus nuclear protein (TNP) has been demonstrated to possess anti-viral activity in HIV-1 patients in five clinical trials, one of which was placebo controlled double-blinded. However, to date molecular mechanisms remain to be identified. Using surface plasmon resonance w...

journal_title：Current HIV research

authors： Mamikonyan G,Kiyatkin A,Movsesyan N,Mkrtichyan M,Ghochikyan A,Petrushina I,Hwang J,Ichim TE,Keledjian H,Agadjanyan MG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Although HIV and injury contribute substantially to disease burdens in lowand middle-income countries (LMIC), their intersection is poorly characterized. OBJECTIVE:This systematic review assessed the prevalence and associated mortality impact of HIVseropositivity among injured patients in LMIC. METHODS:A s...

journal_title：Current HIV research

authors： Aluisio AR,Rege S,Stewart BT,Kinuthia J,Levine AC,Mello MJ,Farquhar C

更新日期：2017-11-23 00:00:00

abstract：OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...

journal_title：Current HIV research

authors： Erdinc FS,Dokuzoguz B,Unal S,Komur S,Inkaya AC,Inan D,Karaoglan I,Deveci A,Celen MK,Kose S,Erben N,Senturk GC,Heper Y,Kutlu SS,Hatipoglu CA,Sumer S,Kandemir B,Sirmatel F,Bayindir Y,Yilmaz E,Ersoy Y,Kazak E,Yil

更新日期：2020-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS and frequently causes neurocognitive impairment. Although antiviral therapy generally reduces the viral load in the CNS and improves HIV-associated neurological dysfunction, most current antiviral drugs have poor CNS penetrance and ...

journal_title：Current HIV research

authors： Dunfee R,Thomas ER,Gorry PR,Wang J,Ancuta P,Gabuzda D

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:There is scarce information about the molecular epidemiology of HIV-infection in Armenia (former USSR). The objective of this work was to estimate the distribution of HIV-1 subtypes in this country and get any information about HIV drug resistance in naÏve patients. DESIGN:A joint study involving 78 patients...

journal_title：Current HIV research

authors： Laga V,Vasilyev A,Lapovok I,Grigoryan S,Papoyan A,Glushchenko N,Kazennova E,Bobkova M

更新日期：2015-01-01 00:00:00

abstract：:AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...

journal_title：Current HIV research

authors： Zeinalipour-Loizidou E,Nicolaou C,Nicolaides A,Kostrikis LG

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...

journal_title：Current HIV research

authors： Kumar A,Upadhyay S,Kumari G

更新日期：2007-09-01 00:00:00

abstract：:Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute t...

journal_title：Current HIV research

authors： Lewis GK

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:HIV-1+ long-term nonprogressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS:We evaluated the plasma levels of IP-10/IL-8 chemokines...

journal_title：Current HIV research

authors： Dos Santos JS,de Almeida SM,Ferreira GS,Bordignon J,Maia Teixeira SL,Martins Lima AC,Raboni SM

更新日期：2017-01-01 00:00:00

abstract：:The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...

journal_title：Current HIV research

authors： Agashe H,Hu M,Rohan L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...

journal_title：Current HIV research

authors： Androutsakos T,Schina M,Pouliakis A,Kontos A,Sipsas N,Hatzis G

更新日期：2019-01-01 00:00:00

abstract：:Most of the HIV-infected long term survivors show strong CD8+ cell noncytotoxic antiviral response (CNAR) that plays as an important factor for maintaining the relative healthy state of infected individuals. HIV infected former blood donors (FBDs) in Anhui, China are the unique population that considered infected by t...

journal_title：Current HIV research

authors： Yuan L,Ma L,Fan X,Feng Y,Peng H,Zhao Q,Ruan Y,Levy JA,Shao Y

更新日期：2009-07-01 00:00:00

abstract：:Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...

journal_title：Current HIV research

authors： Mbonye U,Karn J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Vitamin D deficiency is common in HIV population and has been associated with increased comorbidity risk and poor immunologic status. OBJECTIVE:To evaluate the effect of protease inhibitor lopinavir/ritonavir monotherapy on changes in serum 25-hydroxyvitamin D [25(OH)D] over 48 weeks. METHODS:Thirty-four t...

journal_title：Current HIV research

authors： Crutchley RD,Jacobs DM,Gathe J,Mayberry C,Bulayeva N,Rosenblatt KP,Garey KW

更新日期：2020-08-27 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART), especially with tenofovir disoproxil fumarate (TDF), has been associated with accelerated bone turnover and leads to significant bone loss. OBJECTIVE:We aimed to determine the effect of vitamin D2 and calcium on bone mineral density (BMD) in HIV-infected patients receiving TDF/...

journal_title：Current HIV research

authors： Boontanondha P,Nimitphong H,Musikarat S,Ragkho A,Kiertiburanakul S

更新日期：2020-01-01 00:00:00

abstract：:A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...

journal_title：Current HIV research

authors： Pinter A

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

journal_title：Current HIV research

authors： Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

更新日期：2014-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) is unique in its capacity to produce chronic disease in almost all infected hosts. To accomplish this, it has evolved multiple mechanisms to effectively evade the immune response. HIV encodes at least one protein that makes infected cells resistant to CTL killing by downmodulatin...

journal_title：Current HIV research

authors： Collins KL

更新日期：2003-01-01 00:00:00

abstract：:A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...

journal_title：Current HIV research

authors： Sealy R,Zhan X,Lockey TD,Martin L,Blanchard J,Traina-Dorge V,Hurwitz JL

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. OBJECTIVE:To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurat...

journal_title：Current HIV research

authors： Yoshino Y,Koga I,Wakabayashi Y,Kitazawa T,Ota Y

更新日期：2020-01-01 00:00:00

abstract：:According to the World Health Organization's 2007 estimates, close to 33 million people worldwide are living with HIV/AIDS. Over the past two decades, significant progress has been made in understanding HIV pathogenesis and disease progression, which has allowed the identification of a multitude of drug and vaccine ta...

journal_title：Current HIV research

authors： Endsley AN,Salama NN,Ho RJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade's polymorphisms in its functionally critical regions protease and reverse transcriptase. OBJECTIVE:To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its pare...

journal_title：Current HIV research

authors： Yu G,Li Y,Huang X,Zhou P,Yan J,Yan X,Fu X,Fang Y,Liu J,Li J,He X,Lin P

更新日期：2020-01-01 00:00:00

abstract：:Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...

journal_title：Current HIV research

authors： Desport M,Lewis J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. OBJECTIVE:The objective of this review is to provide updated information on the role of antibodies in the preventio...

journal_title：Current HIV research

authors： Fabra-Garcia A,Beltran C,Sanchez-Merino V,Yuste E

更新日期：2016-01-01 00:00:00

abstract：:Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...

journal_title：Current HIV research

authors： Aizire J,Fowler MG,Coovadia HM

更新日期：2013-03-01 00:00:00

abstract：:While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

journal_title：Current HIV research

authors： Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

更新日期：2010-10-01 00:00:00