Abstract:
BACKGROUND:Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE:To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in a major maternity hospital in the northern region of the Santa Catarina State, Brazil. METHODS:A retrospective study included serological tests for HIV, syphilis and hepatitis B screening of milk donor candidates in the 2005-2015 period. The 95% confidence intervals were calculated using the Poisson distribution. RESULTS:For HIV, the prevalence per 100.000 pregnant women was 155, 170 and zero over the three periods analyzed (2005-2009, 2010-2012 and 2013-2015), respectively. Syphilis prevalence per 100,000 pregnant women was 509, 460 and 1749 in the three periods analyzed. For the HBsAg marker of recent hepatitis B infection, the prevalence on the same scale was 254, 231 and 299, respectively, while the anti-HBc prevalence, a marker of lifetime risk for hepatitis B infection, was 7339 in the 2010-2012 period and 3874 in the 2013-2015 period. CONCLUSION:High prevalence of HIV, syphilis and hepatitis B was found for the 2005-2015 period among breastfeeding mothers who offered to donate their exceeding milk to a human milk bank in Brazil. Despite apparent elimination of the HIV by the end of the period, the decline was not statistically significant. There was no significant change in the acute hepatitis B prevalence over time but the increased syphilis prevalence in the most recent period was statistically significant.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Kupek E,Savi EOdoi
10.2174/1570162X15666170707143541subject
Has Abstractpub_date
2017-01-01 00:00:00pages
291-296issue
4eissn
1570-162Xissn
1873-4251pii
CHR-EPUB-84595journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending ou...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206776055075
更新日期:2006-04-01 00:00:00
abstract::The oral cavity of human immunodeficiency virus type I (HIV-1) infected individuals is subjected to a series of opportunistic infections which are usually considered as a prognostic marker for the severity of infection as well as an indicator of immunodeficiency. The highly active antiretroviral therapy (HAART) has si...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207780636533
更新日期:2007-05-01 00:00:00
abstract::Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) antagonists with combined antiretroviral therapy (cART) is based on mul...
journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140526120831
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666171206120024
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1303150506182534
更新日期:2015-01-01 00:00:00
abstract::Beta defensins are antimicrobial peptides that serve to protect the host from microbial invasion at skin and mucosal surfaces. Here we explore the relationships among beta defensin levels, total bacterial colonization, and colonization by bacterial vaginosis (BV)-related bacteria and lactobacilli in the female genital...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212802429848
更新日期:2012-09-01 00:00:00
abstract::Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210790416370
更新日期:2010-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS and frequently causes neurocognitive impairment. Although antiviral therapy generally reduces the viral load in the CNS and improves HIV-associated neurological dysfunction, most current antiviral drugs have poor CNS penetrance and ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016206777709500
更新日期:2006-07-01 00:00:00
abstract::Revised Centers for Disease Control and Prevention recommendations on HIV testing now promote testing of most risk groups. However, positive results for low-risk individuals are more likely to be false positives than for high-risk individuals, making clear communication of test results even more imperative. In a study...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x13666150511125629
更新日期:2015-01-01 00:00:00
abstract::A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210794088290
更新日期:2010-12-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208783571973
更新日期:2008-01-01 00:00:00
abstract::AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190927154110
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. OBJECTIVE:The objective of this review is to provide updated information on the role of antibodies in the preventio...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162x14999160224103320
更新日期:2016-01-01 00:00:00
abstract::We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209788347958
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apoli...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666181018155827
更新日期:2018-01-01 00:00:00
abstract::The present study assessed the phenotypic aspects of oral-cavity Candida albicans isolates from 300 HIV-1- positive patients, relating the most commonly investigated virulence factors (enzyme typing and germ-tube formation) to the most common morphotypes. The samples were seeded into specific media for isolation and s...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990042
更新日期:2013-06-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190903230622
更新日期:2019-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209787048465
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200427223823
更新日期:2020-01-01 00:00:00
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pub_type: 临床试验
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200720000344
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212799937209
更新日期:2012-03-01 00:00:00
abstract::Superinfection is defined as infection by a second virus during an immunologic steady state, following infection by a primary virus. It is now well established that superinfection with HIV-1 occurs in humans. Detection of an increasing number of circulating recombinant forms, which result from infection of a cell by t...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043351219
更新日期:2004-07-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200827115615
更新日期:2020-08-27 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140807151616
更新日期:2014-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211797636008
更新日期:2011-07-01 00:00:00
abstract::Antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT) of HIV could affect hemoglobin (Hb) development of infants. A cross-sectional descriptive study was conducted in 24 HIV-infected and 21 HIV-uninfected pregnancies. ARV drugs were administered to HIV-infected pregnancies at 21 weeks ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140713170800
更新日期:2014-01-01 00:00:00
abstract::The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162052772933
更新日期:2005-01-01 00:00:00
abstract::Although hepatitis B serology screening has been recommended for HIV care, it has not been routinely performed. We aimed to assess compliance and timing of hepatitis B serology screening among HIV-infected patients in a resource-limited setting. A cross-sectional study was conducted in Thailand. Compliance, timing of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211794582669
更新日期:2011-01-01 00:00:00
abstract::Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800618138
更新日期:2012-04-01 00:00:00