Abstract:
:Premature immunosenescence has been reported in different HIV scenarios. However, how premature is the HIV-related immunosenescent phenotype is still unknown. Thus, the aim of this study was to analyze the immunosenescent status of young viraemic naive HIV-infected individuals, with less than four years from infection. To this end, replicative senescence, activation and proliferation T-cell levels were analyzed in chronically HIV-infected young individuals and both, elderly and young healthy controls. We show that young HIV-infected viraemic patients, with less than four years from infection, have early immune exhaustion leading to a premature immunosenescence comparable to healthy people 40 years elder. In addition, memory T-cell subsets showed greater alterations than elder healthy controls and, in patients with high viral loads, CD57 expression at the memory T-cell subsets was correlated with lower viral increases but higher CD4 T-cell lost during follow up.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Ferrando-Martínez S,Ruiz-Mateos E,Romero-Sánchez MC,Muñoz-Fernández MÁ,Viciana P,Genebat M,Leal Mdoi
10.2174/157016211797636008subject
Has Abstractpub_date
2011-07-01 00:00:00pages
289-94issue
5eissn
1570-162Xissn
1873-4251pii
Abs: CHIVR-161journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x14666160401131426
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666180730144455
更新日期:2018-01-01 00:00:00
abstract::After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209788348001
更新日期:2009-05-01 00:00:00
abstract::The human immunodeficiency virus (HIV) is unique in its capacity to produce chronic disease in almost all infected hosts. To accomplish this, it has evolved multiple mechanisms to effectively evade the immune response. HIV encodes at least one protein that makes infected cells resistant to CTL killing by downmodulatin...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162033352138
更新日期:2003-01-01 00:00:00
abstract::To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162053506919
更新日期:2005-04-01 00:00:00
abstract::Previous studies have demonstrated that nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) act as chemical enhancers of human immunodeficiency virus type 1 (HIV-1) RT dimerization. In the current study, we sought to define the role of key residues (101, 103, 108, 181, 188, 190, 225 and 318) in the NNRTI-bind...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208783885065
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191004093433
更新日期:2019-01-01 00:00:00
abstract::Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212799937209
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190213094624
更新日期:2018-01-01 00:00:00
abstract::Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...
journal_title:Current HIV research
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
abstract::Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surfa...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043485086
更新日期:2004-01-01 00:00:00
abstract::In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. Th...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016207780077020
更新日期:2007-03-01 00:00:00
abstract::It has been known for decades that exogenous RNAs are able to induce cytotoxic T lymphocytes (CTLs) and immunological reactivity to a wide variety of antigens. The molecular events responsible for these effects remain unclear for more than two decades. It has been decided to revisit this phenomenon in the light of new...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016205774370447
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. OBJECTIVE:Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we desig...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191210105809
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:Adolescent girls throughout the globe are particularly vulnerable to HIV infection. In the U.S., sexually-active, adolescent girls in urban settings are at elevated risk for HIV. The purpose of this study was to describe a theoreticallydriven, HIV prevention intervention tailored for adolescent girls and eva...
journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140129110129
更新日期:2013-10-01 00:00:00
abstract::Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666191231105438
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:HIV-1+ long-term nonprogressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS:We evaluated the plasma levels of IP-10/IL-8 chemokines...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666171206120024
更新日期:2017-01-01 00:00:00
abstract::Hodgkin lymphoma (HL) represents one of the most common types of a non-AIDS-defining tumour that occurs in the HIV population, and its incidence is increasing in the post Highly Active Anti-retroviral Therapy (HAART) era. Despite the aggressiveness of that disease, the outcome of patients with HIV-HL has improved with...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210790442704
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x13666150806110238
更新日期:2016-01-01 00:00:00
abstract::We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209788347958
更新日期:2009-05-01 00:00:00
abstract::The cellular protein "Bone marrow stromal antigen 2" (BST2 also called Tetherin, CD317, HM1.24) was identified as a major mediator of the innate immune defense against the dissemination of enveloped viruses. BST2 was shown to physically trap the de novo formed viral particles at the surface of infected cells, thereby ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800792414
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending ou...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206776055075
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190809153245
更新日期:2019-01-01 00:00:00
abstract::A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789346255
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:A vaccine able to elicit broadly neutralizing antibodies capable of blocking infection by global viruses has not been achieved, and remains a key public health challenge. OBJECTIVE:During infection, a robust strain-specific neutralizing response develops in most people, but only a subset of infected people ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162X15666171124122044
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200712173630
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART), especially with tenofovir disoproxil fumarate (TDF), has been associated with accelerated bone turnover and leads to significant bone loss. OBJECTIVE:We aimed to determine the effect of vitamin D2 and calcium on bone mineral density (BMD) in HIV-infected patients receiving TDF/...
journal_title:Current HIV research
pub_type: 临床试验
doi:10.2174/1570162X18666200106150806
更新日期:2020-01-01 00:00:00
abstract::An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162033485140
更新日期:2003-10-01 00:00:00
abstract::Most new HIV infections in sub-Saharan Africa now occur in married and cohabiting couples, many of whom do not realize that only one of them may be infected with HIV. HIV-negative individuals living in stable HIV-discordant partnerships (in which one partner is HIV-infected while the other one is not) are twice as lik...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210793499303
更新日期:2010-09-01 00:00:00
abstract::VGV-1, a clinical-grade formulation of bovine thymus nuclear protein (TNP) has been demonstrated to possess anti-viral activity in HIV-1 patients in five clinical trials, one of which was placebo controlled double-blinded. However, to date molecular mechanisms remain to be identified. Using surface plasmon resonance w...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208785132545
更新日期:2008-06-01 00:00:00