Liver Fibrosis Assessment in a Cohort of Greek HIV Mono-Infected Patients by Non-Invasive Biomarkers.

abstract：BACKGROUND:Vitamin D deficiency is common in HIV population and has been associated with increased comorbidity risk and poor immunologic status. OBJECTIVE:To evaluate the effect of protease inhibitor lopinavir/ritonavir monotherapy on changes in serum 25-hydroxyvitamin D [25(OH)D] over 48 weeks. METHODS:Thirty-four t...

journal_title：Current HIV research

authors： Crutchley RD,Jacobs DM,Gathe J,Mayberry C,Bulayeva N,Rosenblatt KP,Garey KW

更新日期：2020-08-27 00:00:00

abstract：BACKGROUND:Antiretroviral therapy (ART), especially with tenofovir disoproxil fumarate (TDF), has been associated with accelerated bone turnover and leads to significant bone loss. OBJECTIVE:We aimed to determine the effect of vitamin D2 and calcium on bone mineral density (BMD) in HIV-infected patients receiving TDF/...

journal_title：Current HIV research

authors： Boontanondha P,Nimitphong H,Musikarat S,Ragkho A,Kiertiburanakul S

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...

journal_title：Current HIV research

authors： Pulido I,Leal M,Genebat M,Pacheco YM,Sáez ME,Soriano-Sarabia N

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:HIV-1+ long-term nonprogressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS:We evaluated the plasma levels of IP-10/IL-8 chemokines...

journal_title：Current HIV research

authors： Dos Santos JS,de Almeida SM,Ferreira GS,Bordignon J,Maia Teixeira SL,Martins Lima AC,Raboni SM

更新日期：2017-01-01 00:00:00

abstract：:To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...

journal_title：Current HIV research

authors： Tisné C

更新日期：2005-04-01 00:00:00

abstract：:While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

journal_title：Current HIV research

authors： Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 ...

journal_title：Current HIV research

authors： Lakhikumar Sharma A,Ramsing Singh T,Ranjana Devi K,Shanjukumar Singh L

更新日期：2016-01-01 00:00:00

abstract：:A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...

journal_title：Current HIV research

authors： Sealy R,Zhan X,Lockey TD,Martin L,Blanchard J,Traina-Dorge V,Hurwitz JL

更新日期：2009-09-01 00:00:00

abstract：:Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...

journal_title：Current HIV research

authors： Rausch JW,Le Grice SFJ

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate th...

journal_title：Current HIV research

authors： Zheng YH,Xiao SL,He B,He Y,Zhou HY,Chen Z,Zheng LW,He M,Wang HY,Lin YH,Cao J

更新日期：2017-01-01 00:00:00

abstract：:A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...

journal_title：Current HIV research

authors： Pinter A

更新日期：2007-11-01 00:00:00

abstract：:In HIV-1, tRNA(Lys3) serves as the primer for reverse transcriptase, and during viral assembly, the tRNA(Lys) isoacceptors, tRNA(Lys1,2) and tRNA(Lys3), are selectively packaged into the virion. In this review, we shall first discuss the evidence for the formation of a tRNA(Lys) packaging complex, whose components inc...

journal_title：Current HIV research

authors： Kleiman L,Halwani R,Javanbakht H

更新日期：2004-04-01 00:00:00

abstract：:Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...

journal_title：Current HIV research

authors： Mbonye U,Karn J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Many HIV research projects are plagued by the high missing rate of selfreported information during data collection. Also, due to the sensitive nature of the HIV research data, privacy protection is always a concern for data sharing in HIV studies. METHODS:This paper applies a data masking approach, called t...

journal_title：Current HIV research

authors： Pei Q,Chen S,Xiao Y,Wu SS

更新日期：2016-01-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective combined anti-retroviral therapy (cART). Cognitive function has been shown to inversely correlate with decreased synaptic and dendritic density. In this study, macaques inoculated with SIV were examined over a 3-month course of infection...

journal_title：Current HIV research

authors： Helke KL,Queen SE,Mankowski JL

更新日期：2013-06-01 00:00:00

abstract：:Objective was to assess dietary intake and physical activity in a Canadian population sample of male patients with HIV and metabolic abnormalities and to compare the data to Canadian recommendations. Sixty-five HIV-infected men with at least one feature associated with the metabolic syndrome (insulin resistance, dysli...

journal_title：Current HIV research

authors： Arendt BM,Aghdassi E,Mohammed SS,Fung LY,Jalali P,Salit IE,Allard JP

更新日期：2008-01-01 00:00:00

abstract：:Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...

journal_title：Current HIV research

authors： Desport M,Lewis J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immu...

journal_title：Current HIV research

authors： Taborda NA,Correa LA,Feria MG,Rugeles MT

更新日期：2018-01-01 00:00:00

abstract：:AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...

journal_title：Current HIV research

authors： Zeinalipour-Loizidou E,Nicolaou C,Nicolaides A,Kostrikis LG

更新日期：2007-07-01 00:00:00

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apoli...

journal_title：Current HIV research

authors： Iqbal K,Imran M,Ullah S,Jamal M,Waheed Y

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the...

journal_title：Current HIV research

authors： Kessler PA

更新日期：2018-01-01 00:00:00

abstract：:The present study assessed the phenotypic aspects of oral-cavity Candida albicans isolates from 300 HIV-1- positive patients, relating the most commonly investigated virulence factors (enzyme typing and germ-tube formation) to the most common morphotypes. The samples were seeded into specific media for isolation and s...

journal_title：Current HIV research

authors： Menezes TO,Gillet LC,Menezes SA,Feitosa RN,Ishak MO,Ishak R,Marques-da-Silva SH,Vallinoto AC

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...

journal_title：Current HIV research

authors： Gray RT,Heymer KJ,Hoare A,Kwon JA,Thein HH,Lote N,Siba P,Saramony S,Saphonn V,Worth H,Kaldor JM,Wilson DP

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

journal_title：Current HIV research

authors： Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

更新日期：2014-01-01 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：:Antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT) of HIV could affect hemoglobin (Hb) development of infants. A cross-sectional descriptive study was conducted in 24 HIV-infected and 21 HIV-uninfected pregnancies. ARV drugs were administered to HIV-infected pregnancies at 21 weeks ...

journal_title：Current HIV research

authors： Pornprasert S,Wongnoi R,Oberdorfer P,Sirivatanapa P

更新日期：2014-01-01 00:00:00

abstract：:Hodgkin lymphoma (HL) represents one of the most common types of a non-AIDS-defining tumour that occurs in the HIV population, and its incidence is increasing in the post Highly Active Anti-retroviral Therapy (HAART) era. Despite the aggressiveness of that disease, the outcome of patients with HIV-HL has improved with...

journal_title：Current HIV research

authors： Mounier N,Spina M,Spano JP

更新日期：2010-03-01 00:00:00

abstract：UNLABELLED:Some deficient genetic polymorphisms of the innate immune system have been correlated to a higher susceptibility to different infections, especially in immunocompromised patients. The possible association between an increased incidence of pneumococcal bacteremia in HIV-infected patients, and deficient polymo...

journal_title：Current HIV research

authors： Horcajada JP,Lozano F,Muñoz A,Suarez B,Fariñas-Alvarez C,Almela M,Smithson A,Martínez E,Mallolas J,Mensa J,Gatell JM

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...

journal_title：Current HIV research

authors： Kumar A,Upadhyay S,Kumari G

更新日期：2007-09-01 00:00:00