Correlation of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide- like 3G Genetic Variant rs8177832 with HIV-1 Predisposition in Pakistani Population.

abstract：OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...

journal_title：Current HIV research

authors： Sagay AS,Ebonyi AO,Meloni ST,Musa J,Oguche S,Ekwempu CC,Oyebode T,Ejeliogu E,Imade GE,Agbaji OO,Okonkwo P,Kanki PJ

更新日期：2015-01-01 00:00:00

abstract：:In HIV-1 infected cells, over 40 different mRNA species are produced by alternative splicing of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 primary RNA transcripts are not spliced and are exported to the cytoplasm where they serve as mRNA and as genomic RNA. In this article, w...

journal_title：Current HIV research

authors： Stoltzfus CM,Madsen JM

更新日期：2006-01-01 00:00:00

abstract：:Several studies have suggested that aerobic physical activity is safe and beneficial for HIV-infected adults. However, there is information lacking regarding whether HIV-infected patients practice physical activity and to what extent. Therefore, the aim of this systematic review was to determine the prevalence of phys...

journal_title：Current HIV research

authors： Schuelter-Trevisol F,Wolff FH,Alencastro PR,Grigoletti S,Ikeda ML,Brandão AB,Barcellos NT,Fuchs SC

更新日期：2012-09-01 00:00:00

abstract：:Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV ...

journal_title：Current HIV research

authors： Nicastri E,Palmisano L,Sarmati L,D'Ettorre G,Parisi S,Andreotti M,Buonomini A,Pirillo FM,Narciso P,Bellagamba R,Vullo V,Montano M,Di Perri G,Andreoni M

更新日期：2008-05-01 00:00:00

abstract：:Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...

journal_title：Current HIV research

authors： Mbonye U,Karn J

更新日期：2011-12-01 00:00:00

abstract：:Most of the HIV-infected long term survivors show strong CD8+ cell noncytotoxic antiviral response (CNAR) that plays as an important factor for maintaining the relative healthy state of infected individuals. HIV infected former blood donors (FBDs) in Anhui, China are the unique population that considered infected by t...

journal_title：Current HIV research

authors： Yuan L,Ma L,Fan X,Feng Y,Peng H,Zhao Q,Ruan Y,Levy JA,Shao Y

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immu...

journal_title：Current HIV research

authors： Taborda NA,Correa LA,Feria MG,Rugeles MT

更新日期：2018-01-01 00:00:00

abstract：:The oral cavity of human immunodeficiency virus type I (HIV-1) infected individuals is subjected to a series of opportunistic infections which are usually considered as a prognostic marker for the severity of infection as well as an indicator of immunodeficiency. The highly active antiretroviral therapy (HAART) has si...

journal_title：Current HIV research

authors： Parveen Z,Acheampong E,Pomerantz RJ,Jacobson JM,Wigdahl B,Mukhtar M

更新日期：2007-05-01 00:00:00

abstract：:According to the World Health Organization's 2007 estimates, close to 33 million people worldwide are living with HIV/AIDS. Over the past two decades, significant progress has been made in understanding HIV pathogenesis and disease progression, which has allowed the identification of a multitude of drug and vaccine ta...

journal_title：Current HIV research

authors： Endsley AN,Salama NN,Ho RJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade's polymorphisms in its functionally critical regions protease and reverse transcriptase. OBJECTIVE:To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its pare...

journal_title：Current HIV research

authors： Yu G,Li Y,Huang X,Zhou P,Yan J,Yan X,Fu X,Fang Y,Liu J,Li J,He X,Lin P

更新日期：2020-01-01 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...

journal_title：Current HIV research

authors： Taiwo B,Chaplin B,Penugonda S,Meloni S,Akanmu S,Gashau W,Idoko J,Adewole I,Murphy R,Kanki P

更新日期：2010-04-01 00:00:00

abstract：:Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) antagonists with combined antiretroviral therapy (cART) is based on mul...

journal_title：Current HIV research

authors： Barrett JS,Bajaj G,McGuire J,Wu D,Spitsin S,Moorthy G,Zhao X,Tebas P,Evans DL,Douglas SD

更新日期：2014-01-01 00:00:00

abstract：:A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...

journal_title：Current HIV research

authors： Pinter A

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Suboptimal adherence to antiretroviral therapy (ART) is a strong predictor of virologic failure (VF) among people with HIV. Various methods such as patient self-report, pill counts and pharmacy refills have been utilized to monitor adherence. However, there are limited data on the accuracy of combining metho...

journal_title：Current HIV research

authors： Wu P,Johnson BA,Nachega JB,Wu B,Ordonez CE,Hare AQ,Kearns R,Murphy R,Sunpath H,Marconi VC

更新日期：2014-01-01 00:00:00

abstract：:Opioid use in HIV infection has been associated with an increased frequency of neurological disease and cognitive impairment and vitamin A deficiency has been linked to progressive HIV disease in drug users. In this report the potential effects of these factors, alone and in combination, on gamma amino butyric acid (G...

journal_title：Current HIV research

authors： Guo M,Bryant J,Sultana S,Jones O,Royal W 3rd

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:Identifying the genetic variability in vertically transmitted viruses in early infancy is important to understand the disease progression. Being important in HIV-1 disease pathogenesis, vpu gene, isolated from young infants was investigated to understand the viral characteristics. METHOD:Blood samples were o...

journal_title：Current HIV research

authors： Sharma U,Gupta P,Gupta S,Venkatesh S,Husain M

更新日期：2018-01-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) Vpr protein plays multiple roles in HIV-1 replication. In early infection, Vpr provides help in the nuclear localization of pre-integration complex. Subsequently, Vpr induces cell cycle arrest of infected cells at G2/M phase. Cell cycle arrest facilitates higher rate of viral...

journal_title：Current HIV research

authors： Pandey RC,Datta D,Mukerjee R,Srinivasan A,Mahalingam S,Sawaya BE

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Despite intense efforts, AIDS is difficult to tackle by current anti-retroviral therapy (ART) due to its side effects; therefore, there is an urgent need to discover potential, multitarget and low-cost anti-HIV compounds. OBJECTIVE:We have shown that few phytocompounds can potentially inhibit the prime targ...

journal_title：Current HIV research

authors： Vora J,Athar M,Sinha S,Jha PC,Shrivastava N

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...

journal_title：Current HIV research

authors： Digban TO,Iweriebor BC,Obi LC,Nwodo U,Okoh AI

更新日期：2019-01-01 00:00:00

abstract：:Superinfection is defined as infection by a second virus during an immunologic steady state, following infection by a primary virus. It is now well established that superinfection with HIV-1 occurs in humans. Detection of an increasing number of circulating recombinant forms, which result from infection of a cell by t...

journal_title：Current HIV research

authors： Chan DJ

更新日期：2004-07-01 00:00:00

abstract：:Antigenic variation, which is the result of amino acid substitution and genetic evolution, poses a major challenge in the development of vaccines against pathogens with unstable genomes, such as HIV-1 and Influenza. Thus, it is highly important to characterize the relationship of genetic evolution, antigenic variation...

journal_title：Current HIV research

authors： Li F,Gilbert PB,Self SG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate th...

journal_title：Current HIV research

authors： Zheng YH,Xiao SL,He B,He Y,Zhou HY,Chen Z,Zheng LW,He M,Wang HY,Lin YH,Cao J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...

journal_title：Current HIV research

authors： Kumar A,Upadhyay S,Kumari G

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate if the supplementation with multistrain probiotics may be able to modulate T cell response in HIV-1 infected patients and to evaluate the anti-HIV activity of probiotic by studying fecal water (FW) samples. METHODS:Three HIV-1-positive patients (Pt1, Pt2 and Pt3) on l...

journal_title：Current HIV research

authors： Falasca F,Cavallari EN,Innocenti GP,Scagnolari C,Mezzaroma I,Santinelli L,Ceccarelli G,Vullo V,Turriziani O,d'Ettorre G

更新日期：2019-01-01 00:00:00

abstract：:It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...

journal_title：Current HIV research

authors： Tozzi V,Libertone R,Liuzzi G

更新日期：2008-11-01 00:00:00

abstract：:The present study assessed the phenotypic aspects of oral-cavity Candida albicans isolates from 300 HIV-1- positive patients, relating the most commonly investigated virulence factors (enzyme typing and germ-tube formation) to the most common morphotypes. The samples were seeded into specific media for isolation and s...

journal_title：Current HIV research

authors： Menezes TO,Gillet LC,Menezes SA,Feitosa RN,Ishak MO,Ishak R,Marques-da-Silva SH,Vallinoto AC

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Many HIV research projects are plagued by the high missing rate of selfreported information during data collection. Also, due to the sensitive nature of the HIV research data, privacy protection is always a concern for data sharing in HIV studies. METHODS:This paper applies a data masking approach, called t...

journal_title：Current HIV research

authors： Pei Q,Chen S,Xiao Y,Wu SS

更新日期：2016-01-01 00:00:00

abstract：:Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...

journal_title：Current HIV research

authors： Aizire J,Fowler MG,Coovadia HM

更新日期：2013-03-01 00:00:00