Jembrana disease virus: host responses, viral dynamics and disease control.

abstract：:Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute t...

journal_title：Current HIV research

authors： Lewis GK

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. OBJECTIVE:Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we desig...

journal_title：Current HIV research

authors： Safakish M,Hajimahdi Z,Aghasadeghi MR,Vahabpour R,Zarghi A

更新日期：2020-01-01 00:00:00

abstract：:In HIV-1 infected cells, over 40 different mRNA species are produced by alternative splicing of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 primary RNA transcripts are not spliced and are exported to the cytoplasm where they serve as mRNA and as genomic RNA. In this article, w...

journal_title：Current HIV research

authors： Stoltzfus CM,Madsen JM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Despite intense efforts, AIDS is difficult to tackle by current anti-retroviral therapy (ART) due to its side effects; therefore, there is an urgent need to discover potential, multitarget and low-cost anti-HIV compounds. OBJECTIVE:We have shown that few phytocompounds can potentially inhibit the prime targ...

journal_title：Current HIV research

authors： Vora J,Athar M,Sinha S,Jha PC,Shrivastava N

更新日期：2020-01-01 00:00:00

abstract：:Mutation of the human immunodeficiency virus by host cells inhibits viral dissemination by creating non-functional variants. However, viral mutation does not always eliminate the ability of the virus to disseminate and, in fact, is thought to promote persistence by generating functional mutants that evade immunity or ...

journal_title：Current HIV research

authors： Balin SJ,Ross TM,Platt JL,Cascalho M

更新日期：2008-01-01 00:00:00

abstract：:Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) antagonists with combined antiretroviral therapy (cART) is based on mul...

journal_title：Current HIV research

authors： Barrett JS,Bajaj G,McGuire J,Wu D,Spitsin S,Moorthy G,Zhao X,Tebas P,Evans DL,Douglas SD

更新日期：2014-01-01 00:00:00

abstract：:AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...

journal_title：Current HIV research

authors： Zeinalipour-Loizidou E,Nicolaou C,Nicolaides A,Kostrikis LG

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The diversity of the HIV proteome influences the cellular response and development of an effective vaccine, particularly due to the generation of viral variants with mutations located within CD8+ T-cell epitopes. These mutations can affect the recognition of the epitopes, that may result in the selection of ...

journal_title：Current HIV research

authors： Acevedo-Saenz L,Perdomo-Celis F,Montoya CJ,Velilla PA

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Identifying the genetic variability in vertically transmitted viruses in early infancy is important to understand the disease progression. Being important in HIV-1 disease pathogenesis, vpu gene, isolated from young infants was investigated to understand the viral characteristics. METHOD:Blood samples were o...

journal_title：Current HIV research

authors： Sharma U,Gupta P,Gupta S,Venkatesh S,Husain M

更新日期：2018-01-01 00:00:00

abstract：:The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...

journal_title：Current HIV research

authors： Agashe H,Hu M,Rohan L

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...

journal_title：Current HIV research

authors： Sagay AS,Ebonyi AO,Meloni ST,Musa J,Oguche S,Ekwempu CC,Oyebode T,Ejeliogu E,Imade GE,Agbaji OO,Okonkwo P,Kanki PJ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...

journal_title：Current HIV research

authors： Taiwo B,Chaplin B,Penugonda S,Meloni S,Akanmu S,Gashau W,Idoko J,Adewole I,Murphy R,Kanki P

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...

journal_title：Current HIV research

authors： Pulido I,Leal M,Genebat M,Pacheco YM,Sáez ME,Soriano-Sarabia N

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...

journal_title：Current HIV research

authors： Gray RT,Heymer KJ,Hoare A,Kwon JA,Thein HH,Lote N,Siba P,Saramony S,Saphonn V,Worth H,Kaldor JM,Wilson DP

更新日期：2009-11-01 00:00:00

abstract：:One of the major obstacles to effective prolonged CD8 T cell control over HIV and other latent infections may be the intrinsic, genetically programmed barrier to unlimited proliferation that is characteristic of all normal human somatic cells. Replicative senescence, characterized extensively in cell culture for a var...

journal_title：Current HIV research

authors： Effros RB

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...

journal_title：Current HIV research

authors： Digban TO,Iweriebor BC,Obi LC,Nwodo U,Okoh AI

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate th...

journal_title：Current HIV research

authors： Zheng YH,Xiao SL,He B,He Y,Zhou HY,Chen Z,Zheng LW,He M,Wang HY,Lin YH,Cao J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...

journal_title：Current HIV research

authors： Huang C,Ye L,Abdullah AS,Liang B,Jiang J,Ning C,Zang N,Zhang Y,Yang Y,Hu X,Yang Q,Luo C,Lao F,Liu H,Liang H,Huang J

更新日期：2020-01-01 00:00:00

abstract：:Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV ...

journal_title：Current HIV research

authors： Nicastri E,Palmisano L,Sarmati L,D'Ettorre G,Parisi S,Andreotti M,Buonomini A,Pirillo FM,Narciso P,Bellagamba R,Vullo V,Montano M,Di Perri G,Andreoni M

更新日期：2008-05-01 00:00:00

abstract：:Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...

journal_title：Current HIV research

authors： Limou S,Melica G,Coulonges C,Lelièvre JD,Do H,McGinn S,Gut IG,Lévy Y,Zagury JF

更新日期：2012-03-01 00:00:00

abstract：:To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...

journal_title：Current HIV research

authors： Tisné C

更新日期：2005-04-01 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) have been isolated from both HIV-positive and non-HIV diarrheal samples. In this study a collection of 18 isolates from these two groups were compared for biofilm formation and antibiotic resistance and for the presence of 14 virulence-related genes. All the HIV-positive and o...

journal_title：Current HIV research

authors： Jafari A,Shafaei E,Oloomi M,Aghasadeghi MR,Bouzari S

更新日期：2013-12-01 00:00:00

abstract：:Two HIV-1 non B isolates, 98US_MSC5007 and 98US_MSC5016, which have been identified amongst the US Army personnel serving abroad, are known to have originated from other nations. Notwithstanding, they are categorized as American strains. This is because their countries of origin are unknown. American isolates are basi...

journal_title：Current HIV research

authors： Nwankwo N

更新日期：2013-06-01 00:00:00

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending ou...

journal_title：Current HIV research

authors： Moralejo L,Inés S,Marcos M,Fuertes A,Luna G

更新日期：2006-04-01 00:00:00

abstract：:Opioid use in HIV infection has been associated with an increased frequency of neurological disease and cognitive impairment and vitamin A deficiency has been linked to progressive HIV disease in drug users. In this report the potential effects of these factors, alone and in combination, on gamma amino butyric acid (G...

journal_title：Current HIV research

authors： Guo M,Bryant J,Sultana S,Jones O,Royal W 3rd

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...

journal_title：Current HIV research

authors： Zhang Y,Shen Y,Yin L,Qi T,Jia X,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...

journal_title：Current HIV research

authors： Souza TM,Rodrigues DQ,Ferreira VF,Marques IP,da Costa Santos F,Cunha AC,de Souza MC,de Palmer Paixão Frugulhetti IC,Bou-Habib DC,Fontes CF

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...

journal_title：Current HIV research

authors： Androutsakos T,Schina M,Pouliakis A,Kontos A,Sipsas N,Hatzis G

更新日期：2019-01-01 00:00:00

abstract：:Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...

journal_title：Current HIV research

authors： Mbonye U,Karn J

更新日期：2011-12-01 00:00:00