Binding Insight of Anti-HIV Phytocompounds with Prime Targets of HIV: A Molecular Dynamics Simulation Analysis.

abstract：BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

journal_title：Current HIV research

authors： Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

更新日期：2017-01-01 00:00:00

abstract：:Antigenic variation, which is the result of amino acid substitution and genetic evolution, poses a major challenge in the development of vaccines against pathogens with unstable genomes, such as HIV-1 and Influenza. Thus, it is highly important to characterize the relationship of genetic evolution, antigenic variation...

journal_title：Current HIV research

authors： Li F,Gilbert PB,Self SG

更新日期：2007-01-01 00:00:00

abstract：:An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...

journal_title：Current HIV research

authors： Thorne C,Newell ML

更新日期：2003-10-01 00:00:00

abstract：:In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. Th...

journal_title：Current HIV research

authors： Longatti P,Perin A,Comai S,Bertazzo A,Rizzo V,Costa CV,Allegri G

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Tolerability, long-term toxicities and selection of resistant variants limit the use and efficacy of antiretroviral drugs in HIV-positive patients. Novel combinations are needed for mantaining long-term control of HIV replication; nevertheless scarse data are available on protease inhibitor-free dual antiret...

journal_title：Current HIV research

authors： Calcagno A,Montrucchio C,Capetti A,Guaraldi G,Cenderello G,Calza L,Lanzafame M,Marinaro L,Tettoni MC,Trentini L,D'Avolio A,Di Perri G,Bonora S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apoli...

journal_title：Current HIV research

authors： Iqbal K,Imran M,Ullah S,Jamal M,Waheed Y

更新日期：2018-01-01 00:00:00

abstract：:Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...

journal_title：Current HIV research

authors： Aizire J,Fowler MG,Coovadia HM

更新日期：2013-03-01 00:00:00

abstract：:A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...

journal_title：Current HIV research

authors： Lu S,Grimes Serrano JM,Wang S

更新日期：2010-12-01 00:00:00

abstract：:It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...

journal_title：Current HIV research

authors： Tozzi V,Libertone R,Liuzzi G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. OBJECTIVE:The objective of this review is to provide updated information on the role of antibodies in the preventio...

journal_title：Current HIV research

authors： Fabra-Garcia A,Beltran C,Sanchez-Merino V,Yuste E

更新日期：2016-01-01 00:00:00

abstract：:The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...

journal_title：Current HIV research

authors： Agashe H,Hu M,Rohan L

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...

journal_title：Current HIV research

authors： Erdinc FS,Dokuzoguz B,Unal S,Komur S,Inkaya AC,Inan D,Karaoglan I,Deveci A,Celen MK,Kose S,Erben N,Senturk GC,Heper Y,Kutlu SS,Hatipoglu CA,Sumer S,Kandemir B,Sirmatel F,Bayindir Y,Yilmaz E,Ersoy Y,Kazak E,Yil

更新日期：2020-01-01 00:00:00

abstract：:The oral cavity of human immunodeficiency virus type I (HIV-1) infected individuals is subjected to a series of opportunistic infections which are usually considered as a prognostic marker for the severity of infection as well as an indicator of immunodeficiency. The highly active antiretroviral therapy (HAART) has si...

journal_title：Current HIV research

authors： Parveen Z,Acheampong E,Pomerantz RJ,Jacobson JM,Wigdahl B,Mukhtar M

更新日期：2007-05-01 00:00:00

abstract：:We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...

journal_title：Current HIV research

authors： Souza TM,Rodrigues DQ,Ferreira VF,Marques IP,da Costa Santos F,Cunha AC,de Souza MC,de Palmer Paixão Frugulhetti IC,Bou-Habib DC,Fontes CF

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...

journal_title：Current HIV research

authors： Loonam CR,O'Dell SD,Sharp PA,Mullen A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vaccine against HIV-1 is not currently available. In present, Virus like particles (VLPs) as effective strategy was used in several vaccine developing. Two conserved sequences; V3 loop of gp120 and the membrane-proximal external region (MPER) of gp41 are dominant sites for vaccine studies. OBJECTIVE:In this...

journal_title：Current HIV research

authors： Tohidi F,Sadat SM,Bolhassani A,Yaghobi R

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...

journal_title：Current HIV research

authors： Sagay AS,Ebonyi AO,Meloni ST,Musa J,Oguche S,Ekwempu CC,Oyebode T,Ejeliogu E,Imade GE,Agbaji OO,Okonkwo P,Kanki PJ

更新日期：2015-01-01 00:00:00

abstract：:Hodgkin lymphoma (HL) represents one of the most common types of a non-AIDS-defining tumour that occurs in the HIV population, and its incidence is increasing in the post Highly Active Anti-retroviral Therapy (HAART) era. Despite the aggressiveness of that disease, the outcome of patients with HIV-HL has improved with...

journal_title：Current HIV research

authors： Mounier N,Spina M,Spano JP

更新日期：2010-03-01 00:00:00

abstract：:The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...

journal_title：Current HIV research

authors： Pitisuttithum P

更新日期：2005-01-01 00:00:00

abstract：:Two HIV-1 non B isolates, 98US_MSC5007 and 98US_MSC5016, which have been identified amongst the US Army personnel serving abroad, are known to have originated from other nations. Notwithstanding, they are categorized as American strains. This is because their countries of origin are unknown. American isolates are basi...

journal_title：Current HIV research

authors： Nwankwo N

更新日期：2013-06-01 00:00:00

abstract：:Superinfection is defined as infection by a second virus during an immunologic steady state, following infection by a primary virus. It is now well established that superinfection with HIV-1 occurs in humans. Detection of an increasing number of circulating recombinant forms, which result from infection of a cell by t...

journal_title：Current HIV research

authors： Chan DJ

更新日期：2004-07-01 00:00:00

abstract：:Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...

journal_title：Current HIV research

authors： Limou S,Melica G,Coulonges C,Lelièvre JD,Do H,McGinn S,Gut IG,Lévy Y,Zagury JF

更新日期：2012-03-01 00:00:00

abstract：:Several studies have suggested that aerobic physical activity is safe and beneficial for HIV-infected adults. However, there is information lacking regarding whether HIV-infected patients practice physical activity and to what extent. Therefore, the aim of this systematic review was to determine the prevalence of phys...

journal_title：Current HIV research

authors： Schuelter-Trevisol F,Wolff FH,Alencastro PR,Grigoletti S,Ikeda ML,Brandão AB,Barcellos NT,Fuchs SC

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:China has implemented a nation-wide policy to control mother-to-child transmission (MTCT) of the human immunodeficiency virus (HIV) since 2011, yet the efficacy of the control policy is less studied. The aim of the present study was to report the data in the prevention of MTCT of HIV in Nantong city, China. ...

journal_title：Current HIV research

authors： Lou H,Ge X,Xu B,Liu W,Zhou YH

更新日期：2020-01-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：:In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practic...

journal_title：Current HIV research

authors： Martellotta F,Berretta M,Vaccher E,Schioppa O,Zanet E,Tirelli U

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...

journal_title：Current HIV research

authors： Kumar A,Upadhyay S,Kumari G

更新日期：2007-09-01 00:00:00

abstract：:Antiretroviral therapy (ART), for those who have access, has revolutionised the morbidity and mortality consequences of HIV infection. By the end of 2010, 6.6 million people living with HIV in low- and middle-income countries were receiving ART, a dramatic 20-fold increase since 2001, saving millions of lives. In addi...

journal_title：Current HIV research

authors： Sidibe M

更新日期：2011-09-01 00:00:00

abstract：:Modern combination antiretroviral therapy (cART) can bring HIV-1 in blood plasma to level undetectable by standard tests, prevent the onset of acquired immune deficiency syndrome (AIDS), and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, cART is not curative, as within a few weeks of ...

journal_title：Current HIV research

authors： Rausch JW,Le Grice SFJ

更新日期：2020-01-01 00:00:00

abstract：:The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...

journal_title：Current HIV research

authors： Yemisen M,Aydın OA,Gunduz A,Ozgunes N,Mete B,Ceylan B,Karaosmanoglu HK,Yildiz D,Sargin F,Ozaras R,Tabak F

更新日期：2014-01-01 00:00:00