Antiretrovirals for prevention: realizing the potential. closing commentary by the executive director of UNAIDS.

abstract：:Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract ...

journal_title：Current HIV research

authors： Tebit DM,Ndembi N,Weinberg A,Quiñones-Mateu ME

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:Adolescent girls throughout the globe are particularly vulnerable to HIV infection. In the U.S., sexually-active, adolescent girls in urban settings are at elevated risk for HIV. The purpose of this study was to describe a theoreticallydriven, HIV prevention intervention tailored for adolescent girls and eva...

journal_title：Current HIV research

authors： Morrison-Beedy D,Crean HF,Passmore D,Carey MP

更新日期：2013-10-01 00:00:00

abstract：:VGV-1, a clinical-grade formulation of bovine thymus nuclear protein (TNP) has been demonstrated to possess anti-viral activity in HIV-1 patients in five clinical trials, one of which was placebo controlled double-blinded. However, to date molecular mechanisms remain to be identified. Using surface plasmon resonance w...

journal_title：Current HIV research

authors： Mamikonyan G,Kiyatkin A,Movsesyan N,Mkrtichyan M,Ghochikyan A,Petrushina I,Hwang J,Ichim TE,Keledjian H,Agadjanyan MG

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending ou...

journal_title：Current HIV research

authors： Moralejo L,Inés S,Marcos M,Fuertes A,Luna G

更新日期：2006-04-01 00:00:00

abstract：UNLABELLED:Some deficient genetic polymorphisms of the innate immune system have been correlated to a higher susceptibility to different infections, especially in immunocompromised patients. The possible association between an increased incidence of pneumococcal bacteremia in HIV-infected patients, and deficient polymo...

journal_title：Current HIV research

authors： Horcajada JP,Lozano F,Muñoz A,Suarez B,Fariñas-Alvarez C,Almela M,Smithson A,Martínez E,Mallolas J,Mensa J,Gatell JM

更新日期：2009-03-01 00:00:00

abstract：:A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...

journal_title：Current HIV research

authors： Sealy R,Zhan X,Lockey TD,Martin L,Blanchard J,Traina-Dorge V,Hurwitz JL

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Despite intense efforts, AIDS is difficult to tackle by current anti-retroviral therapy (ART) due to its side effects; therefore, there is an urgent need to discover potential, multitarget and low-cost anti-HIV compounds. OBJECTIVE:We have shown that few phytocompounds can potentially inhibit the prime targ...

journal_title：Current HIV research

authors： Vora J,Athar M,Sinha S,Jha PC,Shrivastava N

更新日期：2020-01-01 00:00:00

abstract：:An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...

journal_title：Current HIV research

authors： Thorne C,Newell ML

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...

journal_title：Current HIV research

authors： Pulido I,Leal M,Genebat M,Pacheco YM,Sáez ME,Soriano-Sarabia N

更新日期：2010-04-01 00:00:00

abstract：:Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...

journal_title：Current HIV research

authors： Desport M,Lewis J

更新日期：2010-01-01 00:00:00

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate th...

journal_title：Current HIV research

authors： Zheng YH,Xiao SL,He B,He Y,Zhou HY,Chen Z,Zheng LW,He M,Wang HY,Lin YH,Cao J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...

journal_title：Current HIV research

authors： Androutsakos T,Schina M,Pouliakis A,Kontos A,Sipsas N,Hatzis G

更新日期：2019-01-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：:Previous studies have demonstrated that nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) act as chemical enhancers of human immunodeficiency virus type 1 (HIV-1) RT dimerization. In the current study, we sought to define the role of key residues (101, 103, 108, 181, 188, 190, 225 and 318) in the NNRTI-bind...

journal_title：Current HIV research

authors： Figueiredo A,Zelina S,Sluis-Cremer N,Tachedjian G

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

journal_title：Current HIV research

authors： Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

journal_title：Current HIV research

authors： Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

更新日期：2014-01-01 00:00:00

abstract：:Several studies have suggested that aerobic physical activity is safe and beneficial for HIV-infected adults. However, there is information lacking regarding whether HIV-infected patients practice physical activity and to what extent. Therefore, the aim of this systematic review was to determine the prevalence of phys...

journal_title：Current HIV research

authors： Schuelter-Trevisol F,Wolff FH,Alencastro PR,Grigoletti S,Ikeda ML,Brandão AB,Barcellos NT,Fuchs SC

更新日期：2012-09-01 00:00:00

abstract：:Beta defensins are antimicrobial peptides that serve to protect the host from microbial invasion at skin and mucosal surfaces. Here we explore the relationships among beta defensin levels, total bacterial colonization, and colonization by bacterial vaginosis (BV)-related bacteria and lactobacilli in the female genital...

journal_title：Current HIV research

authors： Jiang W,Ghosh SK,Flyckt R,Kalinowska M,Starks D,Jurevic R,Weinberg A,Lederman MM,Rodriguez B

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to investigate if the supplementation with multistrain probiotics may be able to modulate T cell response in HIV-1 infected patients and to evaluate the anti-HIV activity of probiotic by studying fecal water (FW) samples. METHODS:Three HIV-1-positive patients (Pt1, Pt2 and Pt3) on l...

journal_title：Current HIV research

authors： Falasca F,Cavallari EN,Innocenti GP,Scagnolari C,Mezzaroma I,Santinelli L,Ceccarelli G,Vullo V,Turriziani O,d'Ettorre G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...

journal_title：Current HIV research

authors： Huang C,Ye L,Abdullah AS,Liang B,Jiang J,Ning C,Zang N,Zhang Y,Yang Y,Hu X,Yang Q,Luo C,Lao F,Liu H,Liang H,Huang J

更新日期：2020-01-01 00:00:00

abstract：:Although hepatitis B serology screening has been recommended for HIV care, it has not been routinely performed. We aimed to assess compliance and timing of hepatitis B serology screening among HIV-infected patients in a resource-limited setting. A cross-sectional study was conducted in Thailand. Compliance, timing of ...

journal_title：Current HIV research

authors： Kiertiburanakul S,Chotiprasitsakul D,Atamasirikul K,Sungkanuparph S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...

journal_title：Current HIV research

authors： Gray RT,Heymer KJ,Hoare A,Kwon JA,Thein HH,Lote N,Siba P,Saramony S,Saphonn V,Worth H,Kaldor JM,Wilson DP

更新日期：2009-11-01 00:00:00

abstract：:The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...

journal_title：Current HIV research

authors： Agashe H,Hu M,Rohan L

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. OBJECTIVE:Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we desig...

journal_title：Current HIV research

authors： Safakish M,Hajimahdi Z,Aghasadeghi MR,Vahabpour R,Zarghi A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...

journal_title：Current HIV research

authors： Digban TO,Iweriebor BC,Obi LC,Nwodo U,Okoh AI

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE:To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in ...

journal_title：Current HIV research

authors： Kupek E,Savi EO

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...

journal_title：Current HIV research

authors： Zhang Y,Shen Y,Yin L,Qi T,Jia X,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Tolerability, long-term toxicities and selection of resistant variants limit the use and efficacy of antiretroviral drugs in HIV-positive patients. Novel combinations are needed for mantaining long-term control of HIV replication; nevertheless scarse data are available on protease inhibitor-free dual antiret...

journal_title：Current HIV research

authors： Calcagno A,Montrucchio C,Capetti A,Guaraldi G,Cenderello G,Calza L,Lanzafame M,Marinaro L,Tettoni MC,Trentini L,D'Avolio A,Di Perri G,Bonora S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vaccine against HIV-1 is not currently available. In present, Virus like particles (VLPs) as effective strategy was used in several vaccine developing. Two conserved sequences; V3 loop of gp120 and the membrane-proximal external region (MPER) of gp41 are dominant sites for vaccine studies. OBJECTIVE:In this...

journal_title：Current HIV research

authors： Tohidi F,Sadat SM,Bolhassani A,Yaghobi R

更新日期：2017-01-01 00:00:00