Abstract:
BACKGROUND:Multiple factors have been previously described which could influence adherence to HAART. Our objective is to determine the fundamental factors which influence adherence to highly active antiretroviral therapy in our population. METHODS:A cross-sectional study was made selecting 143 outpatients attending our hospital HIV unit. 22 factors were recorded which could influence adherence to treatment (covering individual factors, the illness itself, the therapeutic regimen and the medical team). Adherence was estimated by the combination of two methods (self-report and pharmacy data); statistical analysis was performed using univariate and multivariate methods. RESULTS:96 patients (67.13%) had good adherence and 47 (32.87%) did not. Only 3 of the 22 factors studied were significant and independent factors related with adherence: employment, housing situation and degree of treatment acceptance. CONCLUSIONS:we have found some differences regarding HAART adherence in our population compared with previous studies. Psychosocial and behavioral factors were the principal ones. We must try to detect patients at high risk of non-adherence in order to take therapeutic decisions properly, try to reinforce adherence and modify the factors associated with poor adherence.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Moralejo L,Inés S,Marcos M,Fuertes A,Luna Gdoi
10.2174/157016206776055075subject
Has Abstractpub_date
2006-04-01 00:00:00pages
221-7issue
2eissn
1570-162Xissn
1873-4251journal_volume
4pub_type
杂志文章abstract:UNLABELLED:Some deficient genetic polymorphisms of the innate immune system have been correlated to a higher susceptibility to different infections, especially in immunocompromised patients. The possible association between an increased incidence of pneumococcal bacteremia in HIV-infected patients, and deficient polymo...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209787581382
更新日期:2009-03-01 00:00:00
abstract::The human immunodeficiency virus (HIV) is unique in its capacity to produce chronic disease in almost all infected hosts. To accomplish this, it has evolved multiple mechanisms to effectively evade the immune response. HIV encodes at least one protein that makes infected cells resistant to CTL killing by downmodulatin...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162033352138
更新日期:2003-01-01 00:00:00
abstract::An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162033485140
更新日期:2003-10-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990042
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200427223823
更新日期:2020-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209789973619
更新日期:2009-11-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
abstract::Passive immunization studies in non-human primates have established unequivocally that virus neutralization can prevent infection, providing the impetus for current intense efforts to identify immunogens that elicit broadly neutralizing antibodies in humans. Although Fc-mediated effector function may also contribute t...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162x113116660060
更新日期:2013-07-01 00:00:00
abstract::Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surfa...
journal_title:Current HIV research
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Current HIV research
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更新日期:2017-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191004093433
更新日期:2019-01-01 00:00:00
abstract::Enteroaggregative Escherichia coli (EAEC) have been isolated from both HIV-positive and non-HIV diarrheal samples. In this study a collection of 18 isolates from these two groups were compared for biofilm formation and antibiotic resistance and for the presence of 14 virulence-related genes. All the HIV-positive and o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140207161000
更新日期:2013-12-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043351084
更新日期:2004-10-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212800792414
更新日期:2012-06-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212802138715
更新日期:2012-07-01 00:00:00
abstract::Antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT) of HIV could affect hemoglobin (Hb) development of infants. A cross-sectional descriptive study was conducted in 24 HIV-infected and 21 HIV-uninfected pregnancies. ARV drugs were administered to HIV-infected pregnancies at 21 weeks ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140713170800
更新日期:2014-01-01 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS and frequently causes neurocognitive impairment. Although antiviral therapy generally reduces the viral load in the CNS and improves HIV-associated neurological dysfunction, most current antiviral drugs have poor CNS penetrance and ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016206777709500
更新日期:2006-07-01 00:00:00
abstract::Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...
journal_title:Current HIV research
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666170511141741
更新日期:2017-01-01 00:00:00
abstract::A major hurdle in the development of a global HIV-1 vaccine is viral diversity. For close to three decades, HIV vaccine development has focused on either the induction of T cell immune responses or antibody responses, and only rarely on both components. After the failure of the STEP trial, the scientific community con...
journal_title:Current HIV research
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200415140652
更新日期:2020-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666171206120024
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Vitamin D deficiency is common in HIV population and has been associated with increased comorbidity risk and poor immunologic status. OBJECTIVE:To evaluate the effect of protease inhibitor lopinavir/ritonavir monotherapy on changes in serum 25-hydroxyvitamin D [25(OH)D] over 48 weeks. METHODS:Thirty-four t...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200827115615
更新日期:2020-08-27 00:00:00
abstract::The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162052772933
更新日期:2005-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210790442704
更新日期:2010-03-01 00:00:00
abstract::In HIV-1, tRNA(Lys3) serves as the primer for reverse transcriptase, and during viral assembly, the tRNA(Lys) isoacceptors, tRNA(Lys1,2) and tRNA(Lys3), are selectively packaged into the virion. In this review, we shall first discuss the evidence for the formation of a tRNA(Lys) packaging complex, whose components inc...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043484988
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:The diversity of the HIV proteome influences the cellular response and development of an effective vaccine, particularly due to the generation of viral variants with mutations located within CD8+ T-cell epitopes. These mutations can affect the recognition of the epitopes, that may result in the selection of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191017105910
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Mother-to-child transmission of HIV-1 occurs in a minority of HIVinfected mother-infant pairs, even without any interventions. The mechanisms that protect the majority of HIV-exposed infants from infection are unclear. T regulatory cells (Treg) have important immunomodulatory functions, but their role in the...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190213094624
更新日期:2018-01-01 00:00:00
abstract::The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140411111803
更新日期:2014-01-01 00:00:00