Abstract:
OBJECTIVES:The aim of the study was to investigate if the supplementation with multistrain probiotics may be able to modulate T cell response in HIV-1 infected patients and to evaluate the anti-HIV activity of probiotic by studying fecal water (FW) samples. METHODS:Three HIV-1-positive patients (Pt1, Pt2 and Pt3) on long-term suppressive combined antiretroviral therapy (cART) received a specific multi-strain probiotic supplementation (Vivomixx ®), for six months (T6). Levels of T cell subsets were evaluated by flow cytometry. Anti- HIV activity of FW samples was evaluated in vitro. RESULTS:CD4+ T cells levels increased in all HIV-1 infected patients whereas activation markers (CD38 and HLA-DR) were decreased both on CD4+ and CD8+ T cells. FW samples presented an increased inhibitory activity against HIV-1 compared to T0 (FW-Pt1: T0 =40%, T6 = 65% of reduction; FW Pt2: T0 = 26%, T6 = 46% of reduction; FW Pt3: T0 = 47%, T6 = 94% of reduction). DISCUSSION:Our data suggest that the administration of the specific probiotic formulation improves the antiviral status of people living with HIV-1 under cART, also modulating T cell response. CONCLUSION:Anti-HIV activity of FW may have several public health and social implications for sexually transmitted diseases that need to be further explored.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Falasca F,Cavallari EN,Innocenti GP,Scagnolari C,Mezzaroma I,Santinelli L,Ceccarelli G,Vullo V,Turriziani O,d'Ettorre Gdoi
10.2174/1570162X17666190903230622subject
Has Abstractpub_date
2019-01-01 00:00:00pages
183-189issue
3eissn
1570-162Xissn
1873-4251pii
CHR-EPUB-100623journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200712173630
更新日期:2020-01-01 00:00:00
abstract::Psychiatric illness is common in HIV-infected patients and underlines the importance for screening not only for cognitive impairment but also for co-morbid mental disease. The rationale for combining immunomodulatory neurokinin- 1 receptor (NK1-R) antagonists with combined antiretroviral therapy (cART) is based on mul...
journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140526120831
更新日期:2014-01-01 00:00:00
abstract::Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviors. The intersection, of the twin epidemics of HIV and drug/alcohol use, results in difficult medical management issues for the health care...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209788680598
更新日期:2009-07-01 00:00:00
abstract::AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190927154110
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191004093433
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190809153245
更新日期:2019-01-01 00:00:00
abstract::Several studies have suggested that aerobic physical activity is safe and beneficial for HIV-infected adults. However, there is information lacking regarding whether HIV-infected patients practice physical activity and to what extent. Therefore, the aim of this systematic review was to determine the prevalence of phys...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212802429794
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200427223823
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Cytokines have been widely demonstrated to involve in the pathogenesis of AIDS and the mechanisms of antiretroviral therapy. Interleukin 27 (IL-27) is a new member of the IL-12 cytokine family and has been shown to interfere HIV-1 virus replication with controversial findings. This study is to investigate th...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666170517130339
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190506155222
更新日期:2019-01-01 00:00:00
abstract::A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207782418470
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:Since 2010, Nigeria has adopted World Health Organization (WHO) 'Option B' which requires administration of triple antiretroviral prophylaxis or treatment (ART) to all HIVinfected pregnant women. We studied the transmission outcomes of HIV-exposed children up to 18 months of age. DESIGN:This was a retrospect...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1303150506182534
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade's polymorphisms in its functionally critical regions protease and reverse transcriptase. OBJECTIVE:To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its pare...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200415140652
更新日期:2020-01-01 00:00:00
abstract::In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practic...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209789973619
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:The diversity of the HIV proteome influences the cellular response and development of an effective vaccine, particularly due to the generation of viral variants with mutations located within CD8+ T-cell epitopes. These mutations can affect the recognition of the epitopes, that may result in the selection of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191017105910
更新日期:2019-01-01 00:00:00
abstract::A current debate in the HIV-1 vaccine field concerns the ability of an immunodeficiency virus to elicit a protective response. One argument is that HIV-1 superinfections are frequent in healthy individuals, because virus evades conventional immune surveillance, a serious obstacle to vaccine design. The opposing argume...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789346255
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Although HIV and injury contribute substantially to disease burdens in lowand middle-income countries (LMIC), their intersection is poorly characterized. OBJECTIVE:This systematic review assessed the prevalence and associated mortality impact of HIVseropositivity among injured patients in LMIC. METHODS:A s...
journal_title:Current HIV research
pub_type: 杂志文章,meta分析,评审
doi:10.2174/1570162X15666170920112743
更新日期:2017-11-23 00:00:00
abstract::It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016208786501535
更新日期:2008-11-01 00:00:00
abstract::The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140411111803
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666180730144455
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x13666150806110238
更新日期:2016-01-01 00:00:00
abstract::Low levels of plasma viremia (below 50 copies/ml of HIV-1 RNA) can be detected in the majority of HIV+ subjects successfully treated with HAART. Aim of our study was to evaluate the impact of different antiretroviral regimens on this residual viremia and on proviral HIV-1 DNA in HAART-treated subjects with plasma HIV ...
journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
doi:10.2174/157016208784325010
更新日期:2008-05-01 00:00:00
abstract::While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210793499169
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Despite intense efforts, AIDS is difficult to tackle by current anti-retroviral therapy (ART) due to its side effects; therefore, there is an urgent need to discover potential, multitarget and low-cost anti-HIV compounds. OBJECTIVE:We have shown that few phytocompounds can potentially inhibit the prime targ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200129112509
更新日期:2020-01-01 00:00:00
abstract::Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016212799937209
更新日期:2012-03-01 00:00:00
abstract::HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective combined anti-retroviral therapy (cART). Cognitive function has been shown to inversely correlate with decreased synaptic and dendritic density. In this study, macaques inoculated with SIV were examined over a 3-month course of infection...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x1131100049
更新日期:2013-06-01 00:00:00
abstract::Among HIV positive patients, Fine needle aspiration cytology (FNAC) or biopsy for diagnosis of tuberculous lymphadenopathy is often avoided due to an unspoken stigma. Earlier, we had developed a clinical scoring scale for the diagnosis of tuberculous lymphadenitis (TBLN), which had 88% sensitivity and detected no fals...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206778560009
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210791111098
更新日期:2010-04-01 00:00:00
abstract::Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211798998736
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666170511141741
更新日期:2017-01-01 00:00:00