14-3-3 Protein in CSF reflects SIV-mediated pre-synaptic damage.

abstract：:We recently described that the chloroxoquinolinic ribonucleoside 6-chloro-1,4-dihydro-4-oxo-1-(beta-D-ribofuranosyl) quinoline-3-carboxylic acid (compound A) inhibits the human immunodeficiency virus type 1 (HIV-1) enzyme reverse transcriptase (RT), and its replication in primary cells. Based on these findings, we per...

journal_title：Current HIV research

authors： Souza TM,Rodrigues DQ,Ferreira VF,Marques IP,da Costa Santos F,Cunha AC,de Souza MC,de Palmer Paixão Frugulhetti IC,Bou-Habib DC,Fontes CF

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The emergence of drug-resistant viral strains has created the need for the development of novel anti-HIV agents with a diverse structure that targets key enzymes in the HIV lifecycle. OBJECTIVE:Considering the pharmacophore of integrase inhibitors, one of the validated targets for anti-HIV therapy, we desig...

journal_title：Current HIV research

authors： Safakish M,Hajimahdi Z,Aghasadeghi MR,Vahabpour R,Zarghi A

更新日期：2020-01-01 00:00:00

abstract：:Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...

journal_title：Current HIV research

authors： Mbonye U,Karn J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 ...

journal_title：Current HIV research

authors： Lakhikumar Sharma A,Ramsing Singh T,Ranjana Devi K,Shanjukumar Singh L

更新日期：2016-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV) infects macrophages and microglia in the CNS and frequently causes neurocognitive impairment. Although antiviral therapy generally reduces the viral load in the CNS and improves HIV-associated neurological dysfunction, most current antiviral drugs have poor CNS penetrance and ...

journal_title：Current HIV research

authors： Dunfee R,Thomas ER,Gorry PR,Wang J,Ancuta P,Gabuzda D

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes. OBJECTIVE:To improve the meth...

journal_title：Current HIV research

authors： Rodriguez J,Prieto S,Correa C,Melo M,Dominguez D,Olarte N,Suárez D,Aragón L,Torres F,Santacruz F

更新日期：2018-01-01 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：:Drug use and HIV/AIDS are global public health issues. The World Health Organization (WHO) estimates that up to 30% of HIV infections are related to drug use and associated behaviors. The intersection, of the twin epidemics of HIV and drug/alcohol use, results in difficult medical management issues for the health care...

journal_title：Current HIV research

authors： Kresina TF,Bruce RD,McCance-Katz EF

更新日期：2009-07-01 00:00:00

abstract：:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...

journal_title：Current HIV research

authors： Jarvis GA,Chang TL

更新日期：2012-04-01 00:00:00

abstract：:Antigenic variation, which is the result of amino acid substitution and genetic evolution, poses a major challenge in the development of vaccines against pathogens with unstable genomes, such as HIV-1 and Influenza. Thus, it is highly important to characterize the relationship of genetic evolution, antigenic variation...

journal_title：Current HIV research

authors： Li F,Gilbert PB,Self SG

更新日期：2007-01-01 00:00:00

abstract：:In HIV-1 infected cells, over 40 different mRNA species are produced by alternative splicing of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 primary RNA transcripts are not spliced and are exported to the cytoplasm where they serve as mRNA and as genomic RNA. In this article, w...

journal_title：Current HIV research

authors： Stoltzfus CM,Madsen JM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...

journal_title：Current HIV research

authors： Huang C,Ye L,Abdullah AS,Liang B,Jiang J,Ning C,Zang N,Zhang Y,Yang Y,Hu X,Yang Q,Luo C,Lao F,Liu H,Liang H,Huang J

更新日期：2020-01-01 00:00:00

abstract：:The human immunodeficiency virus (HIV) is unique in its capacity to produce chronic disease in almost all infected hosts. To accomplish this, it has evolved multiple mechanisms to effectively evade the immune response. HIV encodes at least one protein that makes infected cells resistant to CTL killing by downmodulatin...

journal_title：Current HIV research

authors： Collins KL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...

journal_title：Current HIV research

authors： Zhang Y,Shen Y,Yin L,Qi T,Jia X,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...

journal_title：Current HIV research

authors： Thorne C,Newell ML

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE:To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in ...

journal_title：Current HIV research

authors： Kupek E,Savi EO

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Adolescent girls throughout the globe are particularly vulnerable to HIV infection. In the U.S., sexually-active, adolescent girls in urban settings are at elevated risk for HIV. The purpose of this study was to describe a theoreticallydriven, HIV prevention intervention tailored for adolescent girls and eva...

journal_title：Current HIV research

authors： Morrison-Beedy D,Crean HF,Passmore D,Carey MP

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Vaccine against HIV-1 is not currently available. In present, Virus like particles (VLPs) as effective strategy was used in several vaccine developing. Two conserved sequences; V3 loop of gp120 and the membrane-proximal external region (MPER) of gp41 are dominant sites for vaccine studies. OBJECTIVE:In this...

journal_title：Current HIV research

authors： Tohidi F,Sadat SM,Bolhassani A,Yaghobi R

更新日期：2017-01-01 00:00:00

abstract：:One of the major obstacles to effective prolonged CD8 T cell control over HIV and other latent infections may be the intrinsic, genetically programmed barrier to unlimited proliferation that is characteristic of all normal human somatic cells. Replicative senescence, characterized extensively in cell culture for a var...

journal_title：Current HIV research

authors： Effros RB

更新日期：2003-04-01 00:00:00

abstract：INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...

journal_title：Current HIV research

authors： Pulido I,Leal M,Genebat M,Pacheco YM,Sáez ME,Soriano-Sarabia N

更新日期：2010-04-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：:Antiretroviral drug therapy has significantly improved the prognosis and life expectancy of people living with HIV over the years. But this progress comes with an important caveat that antiretroviral regimens generally require adherence to life-long, daily dosing, to keep viral multiplication under check. Non-adherenc...

journal_title：Current HIV research

authors： Labh R,Gupta R

更新日期：2020-08-23 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) have been isolated from both HIV-positive and non-HIV diarrheal samples. In this study a collection of 18 isolates from these two groups were compared for biofilm formation and antibiotic resistance and for the presence of 14 virulence-related genes. All the HIV-positive and o...

journal_title：Current HIV research

authors： Jafari A,Shafaei E,Oloomi M,Aghasadeghi MR,Bouzari S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:China has implemented a nation-wide policy to control mother-to-child transmission (MTCT) of the human immunodeficiency virus (HIV) since 2011, yet the efficacy of the control policy is less studied. The aim of the present study was to report the data in the prevention of MTCT of HIV in Nantong city, China. ...

journal_title：Current HIV research

authors： Lou H,Ge X,Xu B,Liu W,Zhou YH

更新日期：2020-01-01 00:00:00

abstract：:Among HIV positive patients, Fine needle aspiration cytology (FNAC) or biopsy for diagnosis of tuberculous lymphadenopathy is often avoided due to an unspoken stigma. Earlier, we had developed a clinical scoring scale for the diagnosis of tuberculous lymphadenitis (TBLN), which had 88% sensitivity and detected no fals...

journal_title：Current HIV research

authors： Purohit SD,Purohit V,Mathur ML

更新日期：2006-10-01 00:00:00

abstract：:A major focus of HIV-1 vaccine development has been directed towards a limited number of broadly conserved epitopes in the Envelope (Env) proteins that are sensitive neutralization targets in many primary isolates. However, evidence suggests that these epitopes are poorly immunogenic; similar antibodies are rarely pro...

journal_title：Current HIV research

authors： Pinter A

更新日期：2007-11-01 00:00:00

abstract：:AIDS is a globalized infectious disease. In 2014, UNAIDS launched a global project of "90-90-90" to end the HIV epidemic by 2030. The second and third 90 require 90% of HIV-1 infected individuals receiving antiretroviral therapy (ART) and durable virological suppression. However, wide use of ART will greatly increase ...

journal_title：Current HIV research

authors： Zuo L,Peng K,Hu Y,Xu Q

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...

journal_title：Current HIV research

authors： Gray RT,Heymer KJ,Hoare A,Kwon JA,Thein HH,Lote N,Siba P,Saramony S,Saphonn V,Worth H,Kaldor JM,Wilson DP

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immu...

journal_title：Current HIV research

authors： Taborda NA,Correa LA,Feria MG,Rugeles MT

更新日期：2018-01-01 00:00:00

abstract：:Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...

journal_title：Current HIV research

authors： Desport M,Lewis J

更新日期：2010-01-01 00:00:00