A case for innate immune effector mechanisms as contributors to disease resistance in SIV-infected sooty mangabeys.

abstract：:Most of the HIV-infected long term survivors show strong CD8+ cell noncytotoxic antiviral response (CNAR) that plays as an important factor for maintaining the relative healthy state of infected individuals. HIV infected former blood donors (FBDs) in Anhui, China are the unique population that considered infected by t...

journal_title：Current HIV research

authors： Yuan L,Ma L,Fan X,Feng Y,Peng H,Zhao Q,Ruan Y,Levy JA,Shao Y

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:There is scarce information about the molecular epidemiology of HIV-infection in Armenia (former USSR). The objective of this work was to estimate the distribution of HIV-1 subtypes in this country and get any information about HIV drug resistance in naÏve patients. DESIGN:A joint study involving 78 patients...

journal_title：Current HIV research

authors： Laga V,Vasilyev A,Lapovok I,Grigoryan S,Papoyan A,Glushchenko N,Kazennova E,Bobkova M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

journal_title：Current HIV research

authors： Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

更新日期：2017-01-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：:An estimated 800,000 children acquired HIV-infection in 2002, most as a result of mother-to-child transmission (MTCT), and vertically-acquired HIV infection continues to be of major public health importance. Prevention of MTCT is possible with a combination of interventions including antiretroviral therapy (ART) (usua...

journal_title：Current HIV research

authors： Thorne C,Newell ML

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Due to the persistence of latent HIV-infected cellular reservoirs, HIV virus can not be eradicated completely. OBJECTIVE:To identify proteins related to HIV latency, we performed a subcellular proteomic study in HIV latent cell lines. METHODS:An established HIV-1 latent cell model (J-Lat Tat-GFP Clone A7 c...

journal_title：Current HIV research

authors： Zhang Y,Shen Y,Yin L,Qi T,Jia X,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade's polymorphisms in its functionally critical regions protease and reverse transcriptase. OBJECTIVE:To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its pare...

journal_title：Current HIV research

authors： Yu G,Li Y,Huang X,Zhou P,Yan J,Yan X,Fu X,Fang Y,Liu J,Li J,He X,Lin P

更新日期：2020-01-01 00:00:00

abstract：:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...

journal_title：Current HIV research

authors： Jarvis GA,Chang TL

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Identifying the genetic variability in vertically transmitted viruses in early infancy is important to understand the disease progression. Being important in HIV-1 disease pathogenesis, vpu gene, isolated from young infants was investigated to understand the viral characteristics. METHOD:Blood samples were o...

journal_title：Current HIV research

authors： Sharma U,Gupta P,Gupta S,Venkatesh S,Husain M

更新日期：2018-01-01 00:00:00

abstract：:While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

journal_title：Current HIV research

authors： Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Tuberculosis (TB) is a pandemic infectious disease especially frequent in HIV-infected patients. Toll-like receptor (TLR) 4 has been described to play a main role in the innate immunity against TB. In fact, single nucleotide polymorphisms (SNPs) in TLRs may influence AIDS disease progression. The associati...

journal_title：Current HIV research

authors： Pulido I,Leal M,Genebat M,Pacheco YM,Sáez ME,Soriano-Sarabia N

更新日期：2010-04-01 00:00:00

abstract：:In HIV-1, tRNA(Lys3) serves as the primer for reverse transcriptase, and during viral assembly, the tRNA(Lys) isoacceptors, tRNA(Lys1,2) and tRNA(Lys3), are selectively packaged into the virion. In this review, we shall first discuss the evidence for the formation of a tRNA(Lys) packaging complex, whose components inc...

journal_title：Current HIV research

authors： Kleiman L,Halwani R,Javanbakht H

更新日期：2004-04-01 00:00:00

abstract：:The aim of the study was to report the epidemiological profile of HIV-1 positive patients from, Istanbul, Turkey, which has one of the lowest HIV-1/AIDS prevalences in Europe. The patients were followed by ACTHIV-IST group which was established by the Infectious Diseases Departments of five teaching hospitals (three u...

journal_title：Current HIV research

authors： Yemisen M,Aydın OA,Gunduz A,Ozgunes N,Mete B,Ceylan B,Karaosmanoglu HK,Yildiz D,Sargin F,Ozaras R,Tabak F

更新日期：2014-01-01 00:00:00

abstract：:Jembrana disease virus (JDV) is the most recently discovered member of the lentivirus family and causes an acute clinical disease in Bali cattle with a fatality rate of approximately 15%. It is genetically related to bovine immunodeficiency virus (BIV) to the extent that infections cannot yet be differentially diagnos...

journal_title：Current HIV research

authors： Desport M,Lewis J

更新日期：2010-01-01 00:00:00

abstract：:Beta defensins are antimicrobial peptides that serve to protect the host from microbial invasion at skin and mucosal surfaces. Here we explore the relationships among beta defensin levels, total bacterial colonization, and colonization by bacterial vaginosis (BV)-related bacteria and lactobacilli in the female genital...

journal_title：Current HIV research

authors： Jiang W,Ghosh SK,Flyckt R,Kalinowska M,Starks D,Jurevic R,Weinberg A,Lederman MM,Rodriguez B

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. OBJECTIVE:The objective of this review is to provide updated information on the role of antibodies in the preventio...

journal_title：Current HIV research

authors： Fabra-Garcia A,Beltran C,Sanchez-Merino V,Yuste E

更新日期：2016-01-01 00:00:00

abstract：:Mutation of the human immunodeficiency virus by host cells inhibits viral dissemination by creating non-functional variants. However, viral mutation does not always eliminate the ability of the virus to disseminate and, in fact, is thought to promote persistence by generating functional mutants that evade immunity or ...

journal_title：Current HIV research

authors： Balin SJ,Ross TM,Platt JL,Cascalho M

更新日期：2008-01-01 00:00:00

abstract：:To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...

journal_title：Current HIV research

authors： Tisné C

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. OBJECTIVE:To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurat...

journal_title：Current HIV research

authors： Yoshino Y,Koga I,Wakabayashi Y,Kitazawa T,Ota Y

更新日期：2020-01-01 00:00:00

abstract：:The human immunodeficiency virus-1 (HIV-1) Vpr protein plays multiple roles in HIV-1 replication. In early infection, Vpr provides help in the nuclear localization of pre-integration complex. Subsequently, Vpr induces cell cycle arrest of infected cells at G2/M phase. Cell cycle arrest facilitates higher rate of viral...

journal_title：Current HIV research

authors： Pandey RC,Datta D,Mukerjee R,Srinivasan A,Mahalingam S,Sawaya BE

更新日期：2009-03-01 00:00:00

abstract：:It has been known for decades that exogenous RNAs are able to induce cytotoxic T lymphocytes (CTLs) and immunological reactivity to a wide variety of antigens. The molecular events responsible for these effects remain unclear for more than two decades. It has been decided to revisit this phenomenon in the light of new...

journal_title：Current HIV research

authors： Watanabe MA,de Souza LR,Murad JM,De Lucca FL

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:China has implemented a nation-wide policy to control mother-to-child transmission (MTCT) of the human immunodeficiency virus (HIV) since 2011, yet the efficacy of the control policy is less studied. The aim of the present study was to report the data in the prevention of MTCT of HIV in Nantong city, China. ...

journal_title：Current HIV research

authors： Lou H,Ge X,Xu B,Liu W,Zhou YH

更新日期：2020-01-01 00:00:00

abstract：:Objective was to assess dietary intake and physical activity in a Canadian population sample of male patients with HIV and metabolic abnormalities and to compare the data to Canadian recommendations. Sixty-five HIV-infected men with at least one feature associated with the metabolic syndrome (insulin resistance, dysli...

journal_title：Current HIV research

authors： Arendt BM,Aghdassi E,Mohammed SS,Fung LY,Jalali P,Salit IE,Allard JP

更新日期：2008-01-01 00:00:00

abstract：:Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...

journal_title：Current HIV research

authors： Aizire J,Fowler MG,Coovadia HM

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

journal_title：Current HIV research

authors： Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

更新日期：2014-01-01 00:00:00

abstract：:The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...

journal_title：Current HIV research

authors： Pitisuttithum P

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...

journal_title：Current HIV research

authors： Jaiswal J,Griffin M,Singer SN,Greene RE,Acosta ILZ,Kaudeyr SK,Kapadia F,Halkitis PN

更新日期：2018-01-01 00:00:00

abstract：:Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...

journal_title：Current HIV research

authors： Limou S,Melica G,Coulonges C,Lelièvre JD,Do H,McGinn S,Gut IG,Lévy Y,Zagury JF

更新日期：2012-03-01 00:00:00

abstract：:Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surfa...

journal_title：Current HIV research

authors： Levesque K,Finzi A,Binette J,Cohen EA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Human milk banking has been promoted to provide donated breast milk for at-risk children whose mothers cannot breastfeed them but this effort was hindered by the advent of HIV epidemic. OBJECTIVE:To estimate the seroprevalence of HIV, syphilis and hepatitis B in the blood of human milk donors registered in ...

journal_title：Current HIV research

authors： Kupek E,Savi EO

更新日期：2017-01-01 00:00:00