Association between clinical pathology and multiple genes mRNA expression in Chinese patients with NSCLC.

Abstract:

OBJECTIVE:The aim of this study was to evaluate whether there was an association between pathology type and ERCC1, BRCA1, RRM1, TUBB3, STMN1, TOP2A and epidermal growth factor receptor (EGFR) messenger ribonucleic acid (mRNA) expression level in Chinese patients with non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS:mRNA expression level of these genes was analyzed in 181 cancer tissues by using xTAG-step liquid-chip array. The mRNA expression level of the seven genes was evaluated in association with the clinical pathology type. RESULTS:The average mRNA expression level of the seven genes were ERCC1 (1.02 ± 0.03), BRCA1 (0.15 ± 0.04), RRM1 (0.19 ± 0.05), TUBB3 (0.31 ± 0.06), STMN1 (2.78 ± 0.42), TOP2A (3.04 ± 0.42) and EGFR (0.58 ± 0.09), respectively in Chinese patients with NSCLC. The mRNA expression level of ERCC1, STMN1 and TOP2A genes were statistical different with different pathology type (p(a) < 0.05); STMN1 and TOP2A genes mRNA expression were much higher in squamous cell lung carcinoma than that in non-squamous cell lung carcinoma (p(a) < 0.05). And ERCC1 gene expression was much lower in squamous cell carcinoma than that in non-squamous cell carcinoma (p(a) < 0.05). CONCLUSION:mRNA expression level of STMN1, TOP2A and ERCC1 were correlated with the clinical pathology type.

journal_name

J Cancer Res Ther

authors

Chen G,Jundong GU,Chen J,Liu Y,Song Z

doi

10.4103/0973-1482.119118

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

S98-100

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2013_9_5_98_119118

journal_volume

9 Suppl 2

pub_type

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