Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis.

Abstract:

:Toll-like receptors (TLRs) serve as specific pattern recognition molecules that bind to microbial components to activate innate immunity and instruct and modulate adaptive immunity in the face of immunological danger. Accumulating evidence supports that TLR signaling pathway responses to luminal microbes participate in the development of gastrointestinal malignancies. This review summarizes current knowledge on the roles of TLR in microbiota-associated gastrointestinal cancer metastasis, focusing on TLR recognition of microbiota ligands, initiating inflammation, and promoting tumorigenesis, as well as the therapeutic strategies to target TLR. Studying the link between TLR signaling and gastrointestinal malignancies offers the possibility to identify novel ways to both prevent and treat gastrointestinal cancer.

journal_name

J Cancer Res Ther

authors

Lu Q,Ding H,Li W

doi

10.4103/0973-1482.122509

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

S142-9

eissn

0973-1482

issn

1998-4138

pii

JCanResTher_2013_9_7_140_122509

journal_volume

9 Suppl

pub_type

杂志文章,评审
  • Primary neuroendocrine carcinoma of the vagina with coexistent atypical vaginal adenosis: a rare entity.

    abstract::Primary neuroendocrine carcinoma of the female genital tract is a rare entity with aggressive clinical behavior and a poor prognosis. This kind of malignancy arising in the vagina is extremely rare. We report a case of primary neuroendocrine carcinoma of vagina arising in a setting of atypical vaginal adenosis. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.113422

    authors: Khurana A,Gupta G,Gupta M,Kaur M

    更新日期:2013-04-01 00:00:00

  • Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas.

    abstract:Background:We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome. Methods:We investigated 181 paraffin-embedded B-cell lymphoma samples usin...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_243_18

    authors: Ouyang C,Deng Z,Zhou J,Fu C,Liu S,Tao Y,Xiao D

    更新日期:2019-01-01 00:00:00

  • Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

    abstract:Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_735_18

    authors: Shahzadeh S,Gholami S,Aghamiri SMR,Mahani H,Nabavi M

    更新日期:2020-07-01 00:00:00

  • Identification of activated pathways in lung adenocarcinoma based on network strategy.

    abstract:Background:Lung adenocarcinoma has increased incidence over the past years and is the cause for almost 50% of deaths attributable to lung cancer. The objective of this paper is to identify activated pathways associated with lung adenocarcinoma based on gene co-expression network analysis. Materials and Methods:Kyoto E...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.199458

    authors: Yu B,Li T,Chen J,Wang FQ,Fu JH,Liu SM,Wang Y,Zhang X,Yang HT

    更新日期:2020-07-01 00:00:00

  • Primary pulmonary epithelioid angiosarcoma: A case report and literature review.

    abstract::Primary pulmonary epithelioid angiosarcoma is an extremely rare malignancy. Herein, we report the case of an elderly Chinese patient with primary pulmonary epithelioid angiosarcoma. The 72-year-old man presented with a 1-month history of persistent hemoptysis and left chest pain and weight loss of 3 kg. A chest comput...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/0973-1482.176419

    authors: Zhang Y,Huang X,Peng C,Wang Y,Wu Q,Wu Z,Shao H,Wang W

    更新日期:2018-06-01 00:00:00

  • Villous adenoma of the urinary bladder.

    abstract::Villous adenoma is a known entity in the gastrointestinal tract, but very rare in the urinary tract. It is a benign tumor with excellent prognosis, but its progression to adenocarcinoma is not established. Here, we report an additional case of villous adenoma of the urinary bladder. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.144360

    authors: Pal DK

    更新日期:2015-07-01 00:00:00

  • Tooth agenesis: A susceptible indicator for colorectal cancer?

    abstract:Context/Background:Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2-10% of the general population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless/integration signaling gene, AX...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.168997

    authors: Paranjyothi MV,Kumaraswamy KL,Begum LF,Manjunath K,Litha.,Basheer S

    更新日期:2018-04-01 00:00:00

  • Intractable nausea in a patient with synchronous pancreatic cancer and a fourth-ventricular ependymoma.

    abstract::Symptoms of nausea and vomiting can present a diagnostic challenge for physicians. In this article, we report a patient who was found to have synchronous presentation of an ependymoma and pancreatic cancer. This case illustrates some of the diagnostic challenges in patients with constitutional symptoms. Furthermore, i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.126474

    authors: Chowdhry VK,Carter DA,Shapiro A

    更新日期:2013-10-01 00:00:00

  • Up-regulation of Wnt5a inhibits proliferation and migration of hepatocellular carcinoma cells.

    abstract:Objectives:Increasing evidence suggests that Wnt5a plays an important role in tumorigenesis. In particular, its expression is downregulated in hepatocellular carcinoma (HCC). The aim of this study was to explore the effect of Wnt5a overexpression on HCC cells. Materials and Methods:We transfected the human HCC cell li...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_886_18

    authors: Wang T,Liu X,Wang J

    更新日期:2019-01-01 00:00:00

  • Breast cancer tumor type recognition using graph feature selection technique and radial basis function neural network with optimal structure.

    abstract:Context:Breast cancer is a major cause of mortality in young women in the developing countries. Early diagnosis is the key to improve survival rate in cancer patients. Aims:In this paper an intelligent system is proposed to breast cancer tumor type recognition. Settings and Design:The proposed system includes three m...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.183561

    authors: Zarbakhsh P,Addeh A

    更新日期:2018-04-01 00:00:00

  • Radiation recall phenomenon presenting as myositis triggered by carboplatin plus paclitaxel and related literature review.

    abstract::While most case reports to date are radiation recall dermatitis, radiation recall myositis, which is a distinct form of radiation recall phenomenon caused by carboplatin plus paclitaxel, has not been reported. We treated a 57-year-old female patient who suffered from recurrent cervical cancer. When the patient develop...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件,评审

    doi:10.4103/0973-1482.146090

    authors: Maeng CH,Park JS,Lee SA,Kim DH,Yun DH,Yoo SD,Kim HS,Chon J

    更新日期:2014-10-01 00:00:00

  • Clinical significance of adiponectin expression in colon cancer patients.

    abstract:PURPOSE:Surgery is the definitive treatment for early colon cancers. Adjuvant therapies are used with the aim of eradicating micrometastases and improving cure rates. Recent studies have proposed that adiponectin might be responsible for obesity-related malignancies. We investigated the prognostic value of this cytokin...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.136634

    authors: Canhoroz M,Kanat O,Saraydaroglu O,Buluc E,Avci N,Cubukcu E,Olmez OF,Manavoglu O

    更新日期:2014-04-01 00:00:00

  • SiRNA and epigenetic aberrations in ovarian cancer.

    abstract::Ovarian cancer has the most noteworthy lethal rate around gynecologic malignancies, and it is also considered as the fourth most frequent cancer in the woman in world. Two most critical barriers to treatment of ovarian malignancy are absence of early diagnostic markers and advancement of drug resistance after therapy,...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.153661

    authors: Mirzaei H,Yazdi F,Salehi R,Mirzaei HR

    更新日期:2016-04-01 00:00:00

  • Oral rinse-based cytology and conventional exfoliative cytology: a comparative study.

    abstract:CONTEXT:Simple screening test for resource-challenged areas. AIMS:To compare specimen adequacy and diagnostic agreement between oral rinse-based smears and conventional smears in oral cancer, oral leukoplakia, and normal controls. SETTINGS AND DESIGN:Twenty-five histologically confirmed cases of oral cancer, 29 clini...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.137910

    authors: Mulki S,Shetty P,Pai P

    更新日期:2015-01-01 00:00:00

  • Wnt5a/Ca (2+) /calcineurin/nuclear factor of activated T signaling pathway as a potential marker of pediatric melanoma.

    abstract::Melanoma is rare in children, but its incidence appears to be increasing. Melanoma accounts for the highest mortality among all skin cancer types. This disease is characterized by high-grade malignancy, easy metastasis, poor prognosis, and high death rate. Melanoma in children may be biologically different from that i...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.145788

    authors: Yang Y,Qian Q

    更新日期:2014-11-01 00:00:00

  • Renal cell carcinoma presenting with heart metastasis without inferior vena caval and right atrial involvement.

    abstract::Heart metastasis of renal cell carcinoma (RCC) without vena cava inferior involvement is exceptionally rare. Here, we presented a case of RCC presenting with the right ventricle metastasis without inferior vena caval and right atrial involvement. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.193111

    authors: Sahin S,Karatas F,Hacioglu MB,Aytekin A,Cilbir E,Conkbayir I

    更新日期:2018-01-01 00:00:00

  • Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy.

    abstract:Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell l...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:110.4103/jcrt.JCRT_10_19

    authors: Uysal P,Afsar CU,Sozer V,Inanc B,Agaoglu F,Gural Z,Fazlıoglu NY,Cuhadaroglu C,Uzun H

    更新日期:2020-07-01 00:00:00

  • Care givers' depression, anxiety, distress, and somatization as predictors of identical symptoms in cancer patients.

    abstract:CONTEXT:The critical condition of the cancer patient and the stringent medical procedures do not often warrant the accessibility of the patient for psychological evaluation. Therefore, the study is conceptualized to assess the psychological problems of caregivers, which in turn have their impact upon cancer patients. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.146088

    authors: Padmaja G,Vanlalhruaii C,Rana S,Nandinee D,Hariharan M

    更新日期:2016-01-01 00:00:00

  • The prognostic factors for clinical N1b patients in thyroid papillary carcinoma.

    abstract:Background:The aim of this study is to determine the prognostic factors which affect both disease-free survival (DFS) and overall survival (OS) in thyroid papillary carcinoma with clinical lateral lymph node metastasis. Methods:One hundred and three papillary thyroid carcinomas diagnosed in adult patients received the...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_1011_16

    authors: Yuksel UM,Turanli S,Acar Y,Berberoglu U

    更新日期:2019-07-01 00:00:00

  • Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

    abstract::Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and un...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.204889

    authors: Naphade VV,Kedia SG,Patil P,Khare S

    更新日期:2018-12-01 00:00:00

  • A receiver operated curve-based evaluation of change in sensitivity and specificity of cotinine urinalysis for detecting active tobacco use.

    abstract:BACKGROUND:Tobacco use has been associated with various carcinomas including lung, esophagus, larynx, mouth, throat, kidney, bladder, pancreas, stomach, and cervix. Biomarkers such as concentration of cotinine in the blood, urine, or saliva have been used as objective measures to distinguish nonusers and users of tobac...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.110384

    authors: Balhara YP,Jain R

    更新日期:2013-01-01 00:00:00

  • Epidermal growth factor receptor-activating mutation(E746_T751>VP) in pancreatic ductal adenocarcinoma responds to erlotinib, followed by epidermal growth factor receptor resistance-mediating mutation (A647T): A case report and literature review.

    abstract::Despite recent advances in treatment with multidrug chemotherapy regimens, outcomes of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain very poor. Treatment with targeted therapies has shown marginal benefits due to intrinsic or acquired resistance. Actionable mutations, while detected infrequentl...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/jcrt.JCRT_729_18

    authors: Patel GK,Perry JB,Abdul-Rahim O,Frankel AE,Cameron D,Taylor W,Rocconi RP,Abushahin L,Nelson C,Singh AP,Khushman M

    更新日期:2020-07-01 00:00:00

  • Long-term outcomes of patients with papillary thyroid cancer who did not undergo prophylactic central neck dissection.

    abstract:Aims:The role of prophylactic central neck dissection (CND) in the management of papillary thyroid carcinoma (PTC) is controversial. This study reports outcomes of an observational approach in PTC patients without clinical evidence of lymph node metastasis. Materials and Methods:Patients with PTC who had surgery (with...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/jcrt.JCRT_620_19

    authors: Huang H,Wu L,Liu W,Liu J,Liu Y,Xu Z

    更新日期:2020-09-01 00:00:00

  • What is the role of florine-18 fluorodeoxyglucose/positron emission tomography/computed tomography imaging in well-differentiated thyroid cancers with negative iodine-131 scan high thyroglobulin and normal anti-thyroglobulin levels.

    abstract:PURPOSE:This retrospective study aims to assess the cut-off value of thyroglobulin (Tg) levels in nux or metastatic well-differentiated thyroid cancers (DTCs) with normal anti-Tg levels using with fluorodeoxyglucose/positron emission tomography/computed tomography (FDG PET/CT). MATERIALS AND METHODS:We reviewed FDG PE...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.176412

    authors: Döner RK,Sager S,Görtan FA,Topuz ÖV,Akyel R,Vatankulu B,Baran A,Teksoz S,Sönmezoglu K

    更新日期:2016-04-01 00:00:00

  • MicoRNA-451 is a novel tumor suppressor via targeting c-myc in head and neck squamous cell carcinomas.

    abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) represents as a common malignancy with increasing incidence in the worldwide. The fact of its poor survival rate urgently requires developing efficient predictive biomarkers for clinical use. MicroRNAs (miRNAs) recently represent as a novel direction for early dia...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.168189

    authors: Wang H,Zhang G,Wu Z,Lu B,Yuan D,Li X,Lu Z

    更新日期:2015-10-01 00:00:00

  • Metastatic malignant melanoma affecting stomach.

    abstract::Malignant melanoma has been reported to affect all organs of the human body with the metastasis. Stomach metastases are quite rare in cases of the most commonly reported primaries including, melanoma and breast, and lung carcinomas. This report involves, a 56-year-old man suffering from melanoma of the lower extremity...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.136029

    authors: Eivazi-Ziaei J,Esmaili H

    更新日期:2014-07-01 00:00:00

  • Signal transducer and activator of transcription 3 downregulation in J774A.1 cell line as a model of M2 macrophages in tumor microenvironment.

    abstract:Aim:Tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis, and immune functions within tumor microenvironments. Tumor progression is frequently associated with a phenotypic switch from M1 to M2 in TAM. Activation of signal transdu...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章

    doi:10.4103/0973-1482.187298

    authors: Seyedi Z,Hashemzadeh MR,Colagar AH,Jaafari MR

    更新日期:2018-07-01 00:00:00

  • Renin-producing germ cell tumor in the pineal apparatus and mediastinum: A rare case report.

    abstract::Ectopic extrarenal renin-producing tumor is a rare disease with approximately 30 case reports in English literature. We herein present the first case of renin-producing germ cell tumors in the pineal apparatus and mediastinum. A 26-year-old man who had undergone craniotomy for the treatment of pineal tumor was found t...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.180682

    authors: Uematsu M,Yokouchi H,Tanino Y,Munakata M

    更新日期:2018-09-01 00:00:00

  • Bone metastasis.

    abstract::Rectal cancers may rarely metastasize in bone and when it occurs, is usually preceded by lung and/or liver metastasis. However, whether it may ever bypasses other organs, particularly lung and liver and metastasizes directly to bone or not, is debatable. Some authors have described the presence of isolated bone metast...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 信件

    doi:10.4103/0973-1482.136675

    authors: Aich RK,Suman G,Phalguni G,Jibak B,Diptimoy D

    更新日期:2014-04-01 00:00:00

  • Cutaneous metastasis of transitional cell bladder carcinoma: a rare presentation and literature review.

    abstract::Cutaneous metastasis from transitional cell bladder carcinoma is a rare clinical entity associated with poor prognosis. We present a case of cutaneous metastasis arising from a transitional cell bladder carcinoma in a male patient who had undergone a radical cystectomy and bilateral ureterostomy 17 months previously. ...

    journal_title:Journal of cancer research and therapeutics

    pub_type: 杂志文章,评审

    doi:10.4103/0973-1482.82940

    authors: Salemis NS,Gakis C,Zografidis A,Gourgiotis S

    更新日期:2011-04-01 00:00:00