Intracellular and extracellular adenosine triphosphate in regulation of insulin secretion from pancreatic β cells (β).

abstract：BACKGROUND:Brown adipose tissue (BAT) has been regarded as a potential target organ to combat obesity and related metabolic disorders. However, the effect of BAT activation on the development of diabetic kidney disease (DKD) remains unclear. METHODS:Diabetic mice were induced by streptozotocin (STZ) combined with a hi...

journal_title：Journal of diabetes

authors： Cai YY,Zhang HB,Fan CX,Zeng YM,Zou SZ,Wu CY,Wang L,Fang S,Li P,Xue YM,Guan MP

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...

journal_title：Journal of diabetes

authors： Rastogi A,Hajela A,Prakash M,Khandelwal N,Kumar R,Bhattacharya A,Mittal BR,Bhansali A,Armstrong DG

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its stable analogue exendin-4 maintain glucose homeostasis by modulating insulin secretion from pancreatic β-cells and controlling hepatic glucose output. Glucokinase (GK), by catalysing the first step in glycolysis, plays an important role in glucose-stimulated insulin se...

journal_title：Journal of diabetes

authors： Dhanesha N,Joharapurkar A,Shah G,Dhote V,Kshirsagar S,Bahekar R,Jain M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The effect of postload glucose spikes (PGS), the difference between 2 hour post-load plasma glucose (2hPLPG) and fasting plasma glucose (FPG), on post-myocardial infarction (post-MI) prognosis in nondiabetic patients is unexplored. METHODS:This is a retrospective cohort analysis of 847 nondiabetic post-MI s...

journal_title：Journal of diabetes

authors： Chattopadhyay S,George A,John J,Sathyapalan T

更新日期：2021-03-01 00:00:00

abstract：BACKGROUND:This meta-analysis was performed to quantitatively evaluate the dose-response association between obstructive sleep apnea (OSA) and risk of type 2 diabetes mellitus (T2DM). METHODS:PubMed, Embase, and Web of Science were searched up to 12 December 2018 for articles that assessed the OSA-T2DM association. Ra...

journal_title：Journal of diabetes

authors： Qie R,Zhang D,Liu L,Ren Y,Zhao Y,Liu D,Liu F,Chen X,Cheng C,Guo C,Li Q,Zhou Q,Tian G,Han M,Huang S,Wu X,Qin P,Li J,Cao J,Zhang M,Huang J,Lu J,Li H,Wang J,Cheng R,Hu D

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrat...

journal_title：Journal of diabetes

authors： Ford ES,Zhao G,Li C,Pearson WS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to investigate whether the therapeutic efficacy of acarbose and metformin is correlated with baseline HbA1c levels in Chinese patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Data for 711 subjects were retrieved from the MARCH (Metformin and AcaRbose in...

journal_title：Journal of diabetes

authors： Zhang JP,Wang N,Xing XY,Yang ZJ,Wang X,Yang WY

更新日期：2016-07-01 00:00:00

abstract：:There has been a rapid escalation of type 2 diabetes (T2D) in developing countries, with varied prevalence according to rural vs urban habitat and degree of urbanization. Some ethnic groups (eg, South Asians, other Asians, and Africans), develop diabetes a decade earlier and at a lower body mass index than Whites, hav...

journal_title：Journal of diabetes

authors： Misra A,Gopalan H,Jayawardena R,Hills AP,Soares M,Reza-Albarrán AA,Ramaiya KL

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...

journal_title：Journal of diabetes

authors： Eckert A,Galler A,Papsch M,Hess M,Holder M,Döing C,Bierkamp-Christophersen D,Hammer E,Pappa A,Lanzinger S

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:The aim of the present study was to develop a simple nomogram that can be used to predict the risk of diabetes mellitus (DM) in the asymptomatic non-diabetic subjects based on non-laboratory- and laboratory-based risk algorithms. METHODS:Anthropometric data, plasma fasting glucose, full lipid profile, exerc...

journal_title：Journal of diabetes

authors： Wong CK,Siu SC,Wan EY,Jiao FF,Yu EY,Fung CS,Wong KW,Leung AY,Lam CL

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...

journal_title：Journal of diabetes

authors： Cao X,Wang D,Zhou J,Yuan H,Chen Z

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

journal_title：Journal of diabetes

authors： Khedr NF

更新日期：2017-11-01 00:00:00

abstract：:Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1...

journal_title：Journal of diabetes

authors： Matsumoto S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...

journal_title：Journal of diabetes

authors： Zhang X,Liu J,Su W,Wu J,Wang C,Kong X,Gustafsson JÅ,Ding J,Ma X,Guan Y

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To investigate carbohydrate antigen (CA) 19-9 levels in subjects with different glucose regulation status and assess the relationship between CA 19-9 and glucose regulation status in a Chinese population aged 40 years and older. METHODS:A total of 2792 participants aged 40 years or older with no history of d...

journal_title：Journal of diabetes

authors： Huang Y,Xu Y,Bi Y,Xu M,Lu J,Wang T,Li M,Chen Y,Liu Y,Huang F,Xu B,Zhang J,Wang W,Ning G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) treatment generally requires multiple antihyperglycemic agents. When diet, exercise, and treatment with sulfonylurea and metformin do not achieve glycemic goals, several options are available. The present study evaluated the efficacy and tolerability of sitagliptin 100 mg/day ...

journal_title：Journal of diabetes

authors： Moses RG,Round E,Shentu Y,Golm GT,O'neill EA,Gantz I,Engel SS,Kaufman KD,Goldstein BJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:In people with chronic kidney disease (CKD), HbA1c may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. In the present study we investigated associations of HbA1c, glycated albumin, and fructosamine with fasting gluc...

journal_title：Journal of diabetes

authors： Jung M,Warren B,Grams M,Kwong YD,Shafi T,Coresh J,Rebholz CM,Selvin E

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to assess the quality of diabetes care and characteristics of the healthcare system in underdeveloped rural mountain areas of western China. METHODS:Questionnaires were used to collect data from 288 diabetic patients with a multistage cluster sampling method in Zhongjiang Co...

journal_title：Journal of diabetes

authors： Ke L,Zhang Y,Wang X,Li S,Yang W,Tong N

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:Dipeptidyl peptidase-4 (DPP-4) is responsible for degradation of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), the endogenous incretins that stimulate glucose-dependent insulin secretion. The objective was to evaluate preclinical profile of a novel DPP-4 inhibitor ZYDPLA1. METHODS...

journal_title：Journal of diabetes

authors： Jain MR,Joharapurkar AA,Bahekar RH,Patel H,Jadav P,Kshirsagar SG,Patel VJ,Patel KN,Ramanathan VK,Patel PR,Desai RC

更新日期：2015-09-01 00:00:00

abstract：:Skin autofluorescence is increased in diabetes, rises with age, and predicts diabetes-related complications. Exposure to secondhand smoke, because one or more family members are smokers, further increases skin autofluorescence in children and young adults with type 1 diabetes. Elimination of passive smoking should be ...

journal_title：Journal of diabetes

authors： Vollenbrock CE,Van Waateringe RP,Veeze HJ,Aanstoot HJ,Wolffenbuttel BH

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high-fat diet-induced obese mouse model under a high-fat diet regimen. METHODS: Obese male C57BL/6J (B6) mice were fed either a high-fat (60% kcal), low-fat (10% kcal), or...

journal_title：Journal of diabetes

authors： Hung SC,Anderson WH,Albers DR,Langhorst ML,Young SA

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. METHODS:A population-based cross-sectional study was perform...

journal_title：Journal of diabetes

authors： Xu M,Zhou Y,Xu B,Sun J,Wang T,Lu J,Lai S,Bi Y,Wang W,Ning G

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine the effect of a new self-care guide package on gestational diabetes mellitus (GDM). METHODS:This randomized clinical trial was conducted on 152 women with GDM. The intervention group was provided with the self-care guide package and three face-to-face educational sessi...

journal_title：Journal of diabetes

authors： Kolivand M,Rahimi MA,Keramat A,Shariati M,Emamian MH

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...

journal_title：Journal of diabetes

authors： Fujimoto K,Shibayama Y,Yamaguchi E,Honjo S,Hamasaki A,Hamamoto Y

更新日期：2018-08-01 00:00:00

abstract：:Two years ago, data presented at the annual American Diabetes Association (ADA) meeting in New Orleans showed a marked decrease in deaths, especially those due to cardiovascular disease, with the use of empagliflozin. Two major questions have been asked: (i) was the result a fluke; and (ii) was it a class effect, or w...

journal_title：Journal of diabetes

authors： Drexler A

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:In addition to its glucoregulatory actions, exendin-4, a stable glucagon-like peptide-1 receptor agonist, exhibits protective effects in the pancreas and anti-obesity effects. Suitable combination treatment with other anti-obesity or pancreas protective agents would be an effective approach to optimize these...

journal_title：Journal of diabetes

authors： Patel V,Joharapurkar A,Gandhi T,Patel K,Dhanesha N,Kshirsagar S,Dhote V,Detroja J,Bahekar R,Jain M

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The present study investigated the correlation between urinary α1 -microglobulin as a marker of tubular dysfunction and albumin excretion in children and adolescents with type 1 diabetes (T1D). METHODS:Ninety-two Egyptian patients with T1D were included in the study (mean [± SD] age 14.14 ± 5.13 years). The...

journal_title：Journal of diabetes

authors： Saif A,Soliman N

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:To analyze the glycemic response of Indian patients with type2 diabetes mellitus (T2DM) to combination therapy with vildagliptin and metformin and compare our data with those of clinical trials. METHODS:In a retrospective study of the hospital database, the glycemic control of 280 patients with T2DM who wer...

journal_title：Journal of diabetes

authors： Chatterjee S,Chatterjee S

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort s...

journal_title：Journal of diabetes

authors： Ayubi E,Khalili D,Delpisheh A,Hadaegh F,Azizi F

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to determine the prevalence and risk factors of prediabetes and diagnosed and undiagnosed diabetes mellitus (DM) in rural Bangladesh. METHODS:Using a population-based cluster random sampling strategy, 3104 adults aged ≥30 years were recruited. Fasting capillary blood glucose...

journal_title：Journal of diabetes

authors： Islam FM,Chakrabarti R,Islam MT,Wahab M,Lamoureux E,Finger RP,Shaw JE

更新日期：2016-03-01 00:00:00