Abstract:
BACKGROUND:To investigate the effect of hydroxypropyl methylcellulose (HPMC) on weight loss and metabolic disorders associated with obesity using a high-fat diet-induced obese mouse model under a high-fat diet regimen. METHODS: Obese male C57BL/6J (B6) mice were fed either a high-fat (60% kcal), low-fat (10% kcal), or high-fat diet plus HPMC (4% and 8%) for 5 weeks. Body, mesenteric adipose, and liver weights were determined at the end of the study. In addition, plasma cholesterol, insulin, glucose, adiponectin, and leptin were analyzed to determine the effects of HPMC. Hepatic and fecal lipids were measured to determine the effect of HPMC on lipid absorption and metabolism. RESULTS:Supplementation of the high-fat diet with 4% and 8% HPMC resulted in significant weight loss in obese B6 mice. Furthermore, significant decreases were seen in adipose (30%-40%), liver weights (15%-26%), and concentrations of plasma cholesterol (13%-20%) and hepatic lipids (13%-36%). Supplementation with 8% HPMC led to significant improvements in glucose homeostasis and leptin concentrations. Reductions in plasma cholesterol, glucose, and insulin levels were strongly correlated with reduced leptin concentrations. Moreover, increases in fecal secretion of total bile acids, sterols, and fats indicated altered fat absorption when HPMC was incorporated in the diet. CONCLUSION:The data indicate that HPMC not only reduces body weight, but also normalizes the metabolic abnormalities associated with obesity and suggest that the effects of HPMC on glucose and lipid homeostasis in B6 mice are mediated by improvements in leptin sensitivity resulting from reduced fat absorption.
journal_name
J Diabetesjournal_title
Journal of diabetesauthors
Hung SC,Anderson WH,Albers DR,Langhorst ML,Young SAdoi
10.1111/j.1753-0407.2011.00118.xsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
158-67issue
2eissn
1753-0393issn
1753-0407journal_volume
3pub_type
杂志文章abstract::Pancreatic β-cells secrete insulin when blood glucose levels become high; however, when β-cells are chronically exposed to hyperglycemia, β-cell function gradually deteriorates, which is known as β-cell glucose toxicity. In the diabetic state, nuclear expression of the pancreatic transcription factors pancreatic and d...
journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12331
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journal_title:Journal of diabetes
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doi:10.1111/1753-0407.12161
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journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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journal_title:Journal of diabetes
pub_type: 杂志文章
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/j.1753-0407.2010.00090.x
更新日期:2010-12-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
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journal_title:Journal of diabetes
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12181
更新日期:2015-05-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12549
更新日期:2018-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00193.x
更新日期:2012-12-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12424
更新日期:2017-04-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2010.00066.x
更新日期:2010-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章,评审
doi:10.1111/1753-0407.12098
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total ...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12132
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indice...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12864
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Considerable uncertainty remains about obstructive lung function( OLF) in adults with metabolic syndrome (MetS). The aim of the present study was to examine pulmonary function status in adults with and without MetS. METHODS:We used data from 3109 participants aged ≥20 years of the National Health and Nutrit...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12136
更新日期:2014-11-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2012.00227.x
更新日期:2013-06-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12356
更新日期:2016-07-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12261
更新日期:2016-01-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/j.1753-0407.2009.00046.x
更新日期:2009-12-01 00:00:00
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journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12294
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:There is little information on medication use, trends across time, and the impact of guidelines on appropriate use of antidiabetic drugs in participants with type 2 diabetes mellitus (T2DM) with chronic kidney disease (CKD). METHODS:A cross-sectional analysis of the National Health and Nutrition Examination...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.13003
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing rad...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12957
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12081
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort s...
journal_title:Journal of diabetes
pub_type: 杂志文章
doi:10.1111/1753-0407.12252
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Glucose excursions and hypoglycemia are associated with cardiovascular complications. However, no studies have evaluated glucose excursions and the frequency of hypoglycemia in patients treated with mitiglinide/voglibose versus glimepiride as add-on to dipeptidyl peptidase-4 inhibitor therapy. METHODS:This ...
journal_title:Journal of diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/1753-0407.12658
更新日期:2018-08-01 00:00:00