Urinary α1 -microglobulin and albumin excretion in children and adolescents with type 1 diabetes.

abstract：:Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1...

journal_title：Journal of diabetes

authors： Matsumoto S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention-deficit/hyperactivity disorder) among adolescents and young adults with type 1 diabetes (11-25 years). METHODS:We compared 9368 type 1 diabetes patients with t...

journal_title：Journal of diabetes

authors： Eckert A,Galler A,Papsch M,Hess M,Holder M,Döing C,Bierkamp-Christophersen D,Hammer E,Pappa A,Lanzinger S

更新日期：2020-12-16 00:00:00

abstract：BACKGROUND:Diabetes mellitus affects the systolic and diastolic function of the left ventricle (LV). The aim of the present study was to evaluate the index of myocardial performance (IMP), a new Doppler index, in asymptomatic, normotensive patients with type 2 diabetes mellitus (T2DM). METHODS:The study population con...

journal_title：Journal of diabetes

authors： Saglam H,Seyfeli E,Gul I,Duru M,Gokce C

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The association between dental caries and metabolic syndrome (MetS) is inconsistent. The aim of the present study was to assess the relationship between dental caries and MetS and its components in a middle-aged Chinese population. METHODS:A cross-sectional analysis was performed of 13 998 participants aged...

journal_title：Journal of diabetes

authors： Cao X,Wang D,Zhou J,Yuan H,Chen Z

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:There is a wide variety of dressings currently available for the treatment of diabetic foot ulcers (DFUs). Because of a lack of evidence from head-to-head randomized controlled trials (RCTs), the relative effects of these dressings in DFU patients remain unclear. This study compared the efficacy of nine dres...

journal_title：Journal of diabetes

authors： Zhang X,Sun D,Jiang GC

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Some reports suggest that concentrations of vitamin D are inversely, whereas concentrations of parathyroid hormone (PTH) are directly, associated with prevalent metabolic syndrome. Because of lingering uncertainty about these associations, we examined the cross-sectional associations between serum concentrat...

journal_title：Journal of diabetes

authors： Ford ES,Zhao G,Li C,Pearson WS

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Considerable uncertainty remains about obstructive lung function( OLF) in adults with metabolic syndrome (MetS). The aim of the present study was to examine pulmonary function status in adults with and without MetS. METHODS:We used data from 3109 participants aged ≥20 years of the National Health and Nutrit...

journal_title：Journal of diabetes

authors： Ford ES,Cunningham TJ,Mercado CI

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Currently, there is no consensus regarding the medical treatment of chronic Charcot neuroarthropathy (CN) of foot, except for effective off-loading. Because tarsal bones are predominantly trabecular, teriparatide may improve the macroarchitecture of foot bones in chronic CN. METHODS:People with diabetes and...

journal_title：Journal of diabetes

authors： Rastogi A,Hajela A,Prakash M,Khandelwal N,Kumar R,Bhattacharya A,Mittal BR,Bhansali A,Armstrong DG

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Self-efficacy plays a critical role in diabetes self-care. Herein we explore factors contributing to decreased insulin therapy self-efficacy in insulin-naïve patients with type 2 diabetes mellitus (T2DM) initiating and managing insulin therapy over 36 weeks. METHODS:The study was conducted within an interna...

journal_title：Journal of diabetes

authors： Hayes RP,Curtis B,Ilag L,Nelson DR,Wong M,Funnell M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:An increase in the prevalence of type 2 diabetes mellitus occurs in immigrants from developing regions to Western countries. However, the dynamics of these transitions in relation to the duration of residence in the new environment are not clearly defined. METHODS:Data concerning cardiovascular risk factors...

journal_title：Journal of diabetes

authors： Kalchiem-Dekel O,Shai I,Biderman A,Orenstein A,Cicurel A,Reuven Y,Henkin Y

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin/kexin-type 9 (PCSK9) downregulates clearance of plasma cholesterol by liver. Its inactivation increases this clearance, reducing cardiovascular risk. However, a lack of PCSK9 could also lead to cholesterol accumulation in pancreatic islet beta cells, impairing insulin secreti...

journal_title：Journal of diabetes

authors： Mbikay M,Sirois F,Gyamera-Acheampong C,Wang GS,Rippstein P,Chen A,Mayne J,Scott FW,Chrétien M

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To investigate carbohydrate antigen (CA) 19-9 levels in subjects with different glucose regulation status and assess the relationship between CA 19-9 and glucose regulation status in a Chinese population aged 40 years and older. METHODS:A total of 2792 participants aged 40 years or older with no history of d...

journal_title：Journal of diabetes

authors： Huang Y,Xu Y,Bi Y,Xu M,Lu J,Wang T,Li M,Chen Y,Liu Y,Huang F,Xu B,Zhang J,Wang W,Ning G

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:With the current obesity epidemic, the search for effective weight loss approaches is required. In the present study, changes in weight, body composition and cardiovascular (CV) risk in response to a low-fat, reduced-energy diet (LFRE), a low-carbohydrate/high-protein diet (LCHP), or a commercially available...

journal_title：Journal of diabetes

authors： Rolland C,Hession M,Murray S,Wise A,Broom I

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:A1c, a surrogate measure of glycemic control, is known to have a strong linear correlation with mean plasma glucose (MPG) when analyzed in populations of patients. However, clinically significant intersubject variability in this relationship exists, which suggests that A1c measurements may not reflect actual...

journal_title：Journal of diabetes

authors： Shrom D,Sarwat S,Ilag L,Bloomgarden ZT

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Cross-sectional studies have reported a close association between serum lipopolysaccharide-binding protein (LBP) and many metabolic disorders. However, no longitudinal study has explored the relationship between LBP and type 2 diabetes mellitus (T2DM). The aim of the present study was to investigate the asso...

journal_title：Journal of diabetes

authors： Zhou H,Hu J,Zhu Q,Yang S,Zhang Y,Gao R,Liu L,Wang Y,Zhen Q,Lv Q,Li Q

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic β-cells are destroyed by infiltrating immune cells. Bilateral cooperation of pancreatic β-cells and immune cells has been proposed in the progression of T1D, but as yet no systems study has investigated this possibility. The aims of the study...

journal_title：Journal of diabetes

authors： Safari-Alighiarloo N,Taghizadeh M,Tabatabaei SM,Shahsavari S,Namaki S,Khodakarim S,Rezaei-Tavirani M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies (GWAS) have identified several genetic variants affecting gestational glucose metabolism. However, information regarding their known associations with gestational diabetes mellitus (GDM) risk remains scarce. METHODS:This study examined the associations of 12 gestational gluco...

journal_title：Journal of diabetes

authors： Xie K,Zhang Y,Wen J,Chen T,Kong J,Zhang J,Wu X,Hu C,Xu B,Ji C,Guo X,Wu J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Intrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few stud...

journal_title：Journal of diabetes

authors： Williams KH,Vieira De Ribeiro AJ,Prakoso E,Veillard AS,Shackel NA,Brooks B,Bu Y,Cavanagh E,Raleigh J,McLennan SV,McCaughan GW,Keane FM,Zekry A,Gorrell MD,Twigg SM

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear hormone receptor superfamily of ligand activated transcription factors, which serve as lipid sensors to regulate expression of genes controlling many aspects of cholesterol and fatty acid metabolism. The liver is the central organ in...

journal_title：Journal of diabetes

authors： Zhang X,Liu J,Su W,Wu J,Wang C,Kong X,Gustafsson JÅ,Ding J,Ma X,Guan Y

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Dipeptidyl peptidase-4 (DPP-4) is responsible for degradation of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP), the endogenous incretins that stimulate glucose-dependent insulin secretion. The objective was to evaluate preclinical profile of a novel DPP-4 inhibitor ZYDPLA1. METHODS...

journal_title：Journal of diabetes

authors： Jain MR,Joharapurkar AA,Bahekar RH,Patel H,Jadav P,Kshirsagar SG,Patel VJ,Patel KN,Ramanathan VK,Patel PR,Desai RC

更新日期：2015-09-01 00:00:00

abstract：:This article reviews the known pathophysiological mechanisms of comorbid gastroesophageal reflux disease (GERD) in the diabetic patient, discusses therapeutic options in care, and provides an approach to its evaluation and management. We searched for review articles published in the past 10 years through a PubMed sear...

journal_title：Journal of diabetes

authors： Punjabi P,Hira A,Prasad S,Wang X,Chokhavatia S

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indice...

journal_title：Journal of diabetes

authors： Gurung RL,M Y,Liu S,Liu JJ,Chan SM,Moh MC,Ang K,Tang WE,Sum CF,Tavintharan S,Lim SC,SMART2D Study.

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Diabetes is a risk factor for various cancers, but its prognostic role in renal cell carcinoma (RCC) is controversial and understudied. This study investigated the prognostic value of type 2 diabetes (T2D) in RCC patients. METHODS:The clinicopathological and follow-up data of 451 RCC patients undergoing rad...

journal_title：Journal of diabetes

authors： Yang H,Yin K,Wang Y,Xia M,Zhang R,Wang W,Chen J,Wang C,Shuang W

更新日期：2019-12-01 00:00:00

abstract：:Crossover design has been widely used in late-phase clinical studies, as well as in pharmacokinetic and pharmacodynamic, bioequivalence, and medical device studies; however, its interpretability and applicability continue to be debated. Herein we provide discussions around a crossover design's scientific benefit, appl...

journal_title：Journal of diabetes

authors： Wang T,Malone J,Fu H,Heilmann C,Qu Y,Huster WJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Although niacin often has beneficial effects on the lipoprotein profile, flushing is an untoward effect associated with its use. Aspirin can only reduce the flushing response by 30-40%. Thus, the aim of the present study was to investigate the mechanisms of niacin-induced flushing, with and without aspirin, ...

journal_title：Journal of diabetes

authors： Parson HK,Harati H,Cooper D,Vinik AI

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Glucagon-like peptide-1 (GLP-1) and its stable analogue exendin-4 maintain glucose homeostasis by modulating insulin secretion from pancreatic β-cells and controlling hepatic glucose output. Glucokinase (GK), by catalysing the first step in glycolysis, plays an important role in glucose-stimulated insulin se...

journal_title：Journal of diabetes

authors： Dhanesha N,Joharapurkar A,Shah G,Dhote V,Kshirsagar S,Bahekar R,Jain M

更新日期：2012-12-01 00:00:00

abstract：:Observations from clinical studies suggest that low serum levels of testosterone in men are often associated with obesity, insulin resistance, and metabolic compromise. Indeed, the clinical symptoms of late-onset hypogonadism are markedly similar to those of Type 2 diabetes mellitus (T2DM) and metabolic syndrome, and ...

journal_title：Journal of diabetes

authors： Jones TH

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Uncontrolled diabetes mellitus causes neuronal damage because of increased intracellular glucose. Natural products as complementary therapy may reduce neuronal complications. This study investigated whether fish oil (FO) and wheat germ oil (WGO) supplementation protects the brain in streptozotocin (STZ)-indu...

journal_title：Journal of diabetes

authors： Khedr NF

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Atherosclerosis may be stimulated by the increased presence of insulin and tumor necrosis-factor-α (TNFα) with subsequent expression of vascular cell adhesion molecule-1 (VCAM-1). We hypothesized that extracellular signal-regulated kinase-5 (ERK5) plays an important role in insulin and TNFα-stimulated total ...

journal_title：Journal of diabetes

authors： Mackesy DZ,Goalstone ML

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Adipocyte fatty acid-binding protein (A-FABP) has been recognized as an important player in macrophage cholesterol trafficking and inflammation, and may promote the development of atherosclerosis. To further elucidate the role of A-FABP in atherosclerosis in diabetes, we investigated the relationship between...

journal_title：Journal of diabetes

authors： Ding M,Shi JY,Xing YZ,Sun B,Fang QH,Zhang JY,Zhang QM,Chen LM,Yu DM,Li CJ

更新日期：2018-06-01 00:00:00