Abstract:
PURPOSE:The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS:A total of 1,367 patients with TC and different subsequent therapeutic procedures were followed up between 1970 and 2012. The occurrence of SM was analyzed by standard incidence ratios (SIR). SM occurred in 96 (7.0 %) patients with primary TC. RESULTS:The most frequent SM was TC (SIR 27.4, n = 64); a significantly higher occurrence was observed after primary testicular seminoma. Prostate cancer appeared in 10 patients (SIR 5.2), with a mean age 54.9 years, while the typical age of patients in Slovakia was 71.4 years. Kidney cancer developed in 6 patients, a significant higher SIR was registered only after primary non-seminomas. The mean patient's age was 48.5 years, while the typical age of all male patients in Slovakia was 62.4 years. Other SM had no significantly higher SIR. Colorectal cancer appeared in 8 patients with primary TC, with a mean age 56.0 years, while the typical age of male patients with primary colorectal cancer in Slovakia was 67.1 years. Other non-testicular tumors appeared in 8 patients. SM occurs in 1.5 % of patients following orchiectomy alone, in 4.3 % following radiotherapy, 5.0 % following chemotherapy and in 4.4 % following combined chemo-radiotherapy. CONCLUSIONS:Preliminary analyses indicate increased SM occurrence in patients with primary TC in comparison with the general population, and it also occurs in younger age at the time of SM diagnosis.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Ondrus D,Ondrusova M,Friedova Ldoi
10.1007/s11255-013-0554-4subject
Has Abstractpub_date
2014-04-01 00:00:00pages
749-56issue
4eissn
0301-1623issn
1573-2584journal_volume
46pub_type
杂志文章abstract:OBJECTIVES:To evaluate the treatment alternatives of total avulsion of the ureter from both ends including ureteropelvic junction (UPJ) and ureterovesical junction (UVJ). METHODS:Total ureteral avulsion on both ends of the ureter was examined in 4 cases performing ureteroscopy. In two male patients of the four cases, ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0505-0
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:General and spinal anesthesia are currently in widespread use during transurethral bladder tumor resection. However, local anesthetic methods are claimed to provide sufficient intra-operative analgesia and satisfactory post-operative pain management. We evaluated whether local levobupivacaine infiltration of...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-007-9295-6
更新日期:2008-01-01 00:00:00
abstract::A 40-year-old man was referred to our hospital with gynecomastia and painless swelling of the right scrotum. Ultrasonography revealed a 15 x 10 mm mass with low echogenicity of the right testis. We performed right high orchiectomy. Histologically, Reinke's crystals and capsular invasion by tumor cells were found. Fina...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6661-8
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway. It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2-adrenoreceptor/PKA pathway in the prostate gland. We measured...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0513-0
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Estimation of the glomerular filtration rate (GFR) is required in the assessment of patients with chronic kidney disease (CKD) in order to provide information regarding the functional status of the kidneys. Current guidelines advocate the use of prediction equations, such as the Cockcroft-Gault (CG) formula ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9515-8
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Chronic kidney disease (CKD) is a major public health problem worldwide, due to its epidemic proportions and to its association with high cardiovascular risk. Therefore, screening for CKD is an increasingly important concept, aiming for early detection and prevention of progression and complications of thi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9923-z
更新日期:2012-02-01 00:00:00
abstract::This study presents a view of the knowledge the authors have gathered during 11 years of work with radioisotope examinations of the kidneys and ureteral urine passage performed in 34 children. As an important indication field they consider the conditions where excretory urography or separate functional examination, re...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02217144
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. METHODS:Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention g...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02423-z
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:It is unclear whether any significant changes in the epidemiology of chronic kidney disease (CKD), possibly resulting from the exceedingly rapid economic development and the aggressive prevention and treatment of kidney diseases in the Chinese population, have occurred over the past two decades. METHODS:The...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0194-0
更新日期:2012-08-01 00:00:00
abstract::The recommended treatment for patients with severe bleeding from upper gastrointestinal (GI) metastases is embolisation. We report a case in which despite adequate embolisation major haemorrhage from renal cell carcinoma (RCC) gastric metastases continually recurred. During a severe bleed refractory to embolisation oc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-0251-z
更新日期:2005-01-01 00:00:00
abstract::Non-gonococcal urethritis (NGU) is the most common disease of the genital tract in men. Recent studies have recommended avoiding the empiric antibiotic administrations that constitute the classical treatment approach in NGU and to aim toward treatment of causative pathogens. However, the classification of NGU agents r...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-019-02140-2
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the new medical device Transurethral Suprapubic endo-Cystostomy (T-SPeC(®)), used for suprapubic catheter (SPC) placement via the transurethral (inside-to-out) approach, and examine the 30-day outcomes in the first US series. METHODS:IRB approval was obtained for this prospective s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0884-x
更新日期:2015-02-01 00:00:00
abstract::The urethral syndrome is generally not associated clinically with urethral changes, however, histology often reveals inflammatory or degenerative alterations. The conventionally diagnosed urethral syndrome can certainly be considered to be a synonym of chronic urethritis in adult females. The remarkable histological l...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082229
更新日期:1979-01-01 00:00:00
abstract:INTRODUCTION:Renal function after renal surgery depends on the volume of renal parenchyma loss and improves in the postoperative period. However, the knowledge on kidney function after radical (RN) and partial (PN) nephrectomy is still insufficient. The aim of this study is to analyze the global renal function and comp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0058-z
更新日期:2012-06-01 00:00:00
abstract::Insulin resistance is characterized by the systemic impairment of insulin action and is usually the result of aging, obesity, chronic inflammation, or another factor that may contribute to the inhibition of the insulin signaling pathway. Insulin resistance is accompanied by defects in lipid metabolism and blood coagul...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-007-9244-4
更新日期:2008-01-01 00:00:00
abstract::Hugely dilated kidneys can sometimes present as abdominal masses. These kidneys are invariably non-functioning and are managed by nephrectomy. We describe a case of massive kidney containing 12.5 litres on fluid which was managed by retroperitoneoscopic nephrectomy. The patient was a 24-year-old male who presented wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007139613615
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To examine the survival effect of treatment delays from the time of confirmed diagnosis of prostate cancer to first treatment in an Australian population. METHODS:Three thousand one hundred and forty patients were identified from the South Australian Prostate Cancer Clinical Outcomes Collaborative database ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1508-z
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:To prospectively compare biopsy outcomes between free-hand transperineal mpMRI/TRUS fusion targeted biopsy (TB) and transperineal systematic biopsy (SB) in patients with first prostate biopsy. PATIENTS AND METHODS:In all, 224 consecutive patients with the suspicion of PCa were investigated. All patients wer...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1484-8
更新日期:2017-03-01 00:00:00
abstract::This study compares the safety and efficacy of mechanical cystolithotripsy (MCLT) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of vesical stones. In the last four years we have treated 144 bladder lithiasis patients with MCLT (86; group A) and ESWL (58; group B). All patients in group A were treat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768241
更新日期:1994-01-01 00:00:00
abstract::Posttransplant lymphoproliferative disorders (PTLD) are commonly caused by Ebstein-Barr Virus infection. The role of hepatitis C virus (HCV) in the genesis of lymphomas has been recognized recently. We report a HCV infected renal transplant recipient who developed PTLD 11 months after transplantation. Reduction of imm...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-0050-1
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To evaluate in an experimental model, the mobility of a novel peritoneal dialysis catheter with a metallic tip (Mag-Cath) using an extra-corporeal magnet. MATERIALS AND METHODS:The Mag-Cath was installed in a porcine model under general anesthesia using laparoscopic access. A senior urologist, a urology reside...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02594-9
更新日期:2021-01-01 00:00:00
abstract:AIM:The aim of the present study was to determine whether administration of zolpidem, a nonbenzodiazepine sedative-hypnotic agent, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with lower urinary tract symptoms (LUTS). MATERIALS AND METHODS:The study inclusion criter...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9206-x
更新日期:2007-01-01 00:00:00
abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVES:To investigate the value of proliferating cell nuclear antigen (PCNA), Ki-67 antigen labelling indices and nucleolar organizer region (NOR) score in relation to histological grade, stage, recurrence and progression of the bladder tumor. MATERIALS AND METHODS:Tissue specimens from 77 bladder cancer patients ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014452902976
更新日期:2002-01-01 00:00:00
abstract::Fifteen patients with urinary retention following rectal resection were examined urodynamically, including cystometry and simultaneous measurement of flow and pressure in the bladder and in the abdomen. Five patients suffered from bladder neck obstruction. This was in most cases put down to a preexisting prostatic enl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081813
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. OBJECTIVE:To evaluate...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02682-w
更新日期:2020-10-31 00:00:00
abstract::The effects of haemodialysate and its three peptide fractions on acetylcholinesterase (AChE, E.C. 3.1.1.7) activity in erythrocytes from healthy subjects and patients with terminal renal insufficiency treated by repeated haemodialyses have been studied. It was shown that erythrocytes from haemodialysed patients displa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Proteinuric renal diseases are often associated with progressive tubulointerstitial fibrosis that usually defines the degree and rate of progression of renal failure. Glomerular filtration of excess albumin, the dominant protein in proteinuria, into proximal tubule could provide the stimulus to induce certai...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9249-z
更新日期:2007-01-01 00:00:00
abstract::Ureteroscopy is now in routine use for the diagnosis and treatment of various pathologies in the upper urinary tract. We report here on our experience in diagnostic and therapeutic applications of the 11.5 F rigid ureteroscope in 85 patients and 88 ureters. An overall success rate of 68.18% (60/88) was achieved when t...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02767719
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:The current study was carried out to assess the effects of omega-3 fatty acid and alpha-tocopherol co-supplementation on malnutrition-inflammation score (MIS), biomarkers of inflammation and oxidative stress in chronic hemodialysis (HD) patients. METHODS:In a randomized double-blind placebo-controlled clinic...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-016-1399-4
更新日期:2016-11-01 00:00:00