Abstract:
OBJECTIVE:The current study was carried out to assess the effects of omega-3 fatty acid and alpha-tocopherol co-supplementation on malnutrition-inflammation score (MIS), biomarkers of inflammation and oxidative stress in chronic hemodialysis (HD) patients. METHODS:In a randomized double-blind placebo-controlled clinical trial, 120 patients with chronic HD were included. Patients were randomly allocated into four groups to receive: (1) 1250 mg/day omega-3 fatty acid containing 600 mg EPA and 300 mg DHA + alpha-tocopherol placebo (n = 30); (2) 400 IU/day alpha-tocopherol + omega-3 fatty acids placebo (n = 30); (3) 1250 mg omega-3 fatty acids/day + 400 IU/day alpha-tocopherol (n = 30); and (4) omega-3 fatty acids placebo + alpha-tocopherol placebo (n = 30) for 12 weeks. RESULTS:After 12 weeks of intervention, all three groups of alpha-tocopherol only, individual omega-3 fatty acids, and combined omega-3 fatty acids and alpha-tocopherol experienced a significant improvements in MIS compared with the placebo group; however, improvements were much greater in the individual omega-3 fats (-1.4 ± 1.4) and combined omega-3 fats and alpha-tocopherol (-1.1 ± 2.3) groups compared with alpha-tocopherol group alone (-0.5 ± 1.7, P = 0.004). Furthermore, both individual and combined intervention with omega-3 fats and alpha-tocopherol led to a significant increase in plasma nitric oxide (NO) (combined group: +17.6 ± 29.3; alpha-tocopherol: +43.1 ± 36.3; omega-3 fats: +31.0 ± 40.0; and placebo: -0.5 ± 18.5 µmol/L, respectively, P < 0.001) and total antioxidant capacity (TAC) (+64.9 ± 113.6, +53.0 ± 144.6, +57.6 ± 157.8 and -69.9 ± 215.1 mmol/L, respectively, P = 0.004) levels. CONCLUSION:Overall, omega-3 fatty acids and alpha-tocopherol co-supplementation for 12 weeks among HD patients improved MIS, plasma NO and TAC levels. Future studies with longer duration of the intervention are needed to confirm the validity of our findings. CLINICAL REGISTRATION: www.irct.ir as IRCT201410245623N28.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Asemi Z,Soleimani A,Shakeri H,Mazroii N,Esmaillzadeh Adoi
10.1007/s11255-016-1399-4subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1887-1895issue
11eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1399-4journal_volume
48pub_type
杂志文章,随机对照试验abstract:INTRODUCTION:To find the most beneficial method, we assessed patient comfort and morbidity rates during prostate biopsy procedures performed using periprostatic nerve blockade, unilateral pudendal nerve blockade, intrarectal lidocaine gel, and a combination of periprostatic nerve blockade and intrarectal lidocaine gel....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9237-3
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP). METHODS:A total of 172 CNBP patients and 151 healthy males were recruite...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0743-9
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-0932-1
更新日期:2015-04-01 00:00:00
abstract::An unusual case of a 15-year-old male who presented with a characteristic clinical syndrome of testicular torsion one week prior to our observation, is reported. During our intervention the testicle was not removed but, on the contrary, restoration of a satisfactory testicular albugineal appearance was achieved. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007189111613
更新日期:1999-01-01 00:00:00
abstract::The authors present four cases of operatively confirmed anorchism. The plasma levels of testosterone and 11-deoxy-17-ketosteroids and dehydroisoandrosterone in urine were low in all cases. After stimulation with HCG, plasma testosterone levels increased in two cases and did not change in another two. The levels of 11-...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082812
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:To assess whether conservative treatment of pediatric patients with neurogenic detrusor overactivity (NDO) results in lower bladder pressure and increased expected bladder volume (EBV), we investigated the clinical and urodynamic effects of long-term intravesical oxybutynin instillation compared with a stand...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0030-y
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Sodium restriction is important for the management of chronic kidney disease (CKD). The present study evaluated the factors impacting dietary sodium restriction in a cohort of Chinese patients with CKD. METHODS:A questionnaire on dietary sodium restriction was administered to patients with non-dialysis CKD who...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1223-1
更新日期:2016-05-01 00:00:00
abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:No safe ultrasound (US) parameters have been established to differentiate the causes of graft dysfunction. OBJECTIVES:To define US parameters and identify the predictors of normal graft evolution, delayed graft function (DGF), and rejection at the early period after kidney transplantation. METHODS:Between Jun...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0896-6
更新日期:2015-02-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract::Pyonephrosis is uncommon in adult and paediatric population and very rare in neonates. Neonatal candidal and staphylococcal pyonephrosis has been reported earlier, and this is the first reported case of MRSA pyonephrosis. A case of potentially lethal fulminating primary MRSA pyonephrosis with septic shock in a neonate...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0260-7
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:Uremic toxins produced by gut microbiota (indoxyl sulfate-IS, p-cresyl sulfate-p-CS, and indole-3-acetic acid-IAA) accumulate in hemodialysis (HD) patients and exhibit potent inflammatory effects. However, the impact of these toxins on nuclear E2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) expres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1748-y
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:It has been shown that residual renal function but not peritoneal clearance predicted patients' survival in peritoneal dialysis therapy. In the present study, we tried to explore the potential causes resulting in the difference between residual renal function and peritoneal dialysis in continuous ambulatory ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-4011-x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease is the most common cause of death in patients with chronic kidney disease (CKD). Epicardial adipose tissue (EAT) is an independent predictor of cardiovascular disease in the general population, and usually increases in the patients with cardiovascular disease risk. The change of EAT in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02575-y
更新日期:2020-12-01 00:00:00
abstract::Hugely dilated kidneys can sometimes present as abdominal masses. These kidneys are invariably non-functioning and are managed by nephrectomy. We describe a case of massive kidney containing 12.5 litres on fluid which was managed by retroperitoneoscopic nephrectomy. The patient was a 24-year-old male who presented wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007139613615
更新日期:2000-01-01 00:00:00
abstract::Investigating the reliability of using some clinical and laboratory parameters as long-term prognostic factors in properly selected patients for stress urinary surgery could help in the prediction of the long-term result in each case. Toward this goal 51 women were examined prospectively, after they were assessed by c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02575219
更新日期:1995-01-01 00:00:00
abstract::A new method of one-stage surgical correction of distal to penoscrotal hypospadias is described. The chordee is released by skin lysis alone and urethroplasty is done by the flip-flap technique while the globular glans is rerolled over the new urethra, all in one stage. The complication rate was minimal (15 per cent),...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082566
更新日期:1984-01-01 00:00:00
abstract::A total of 32 female patients with urinary stress incontinence who underwent a Stamey endoscopic bladder neck suspension were clinically and urodynamically studied pre- and postoperatively. Complete cure was obtained in 78% of the patients and improvement in 6%, the overall success rate being 84% for a mean follow-up ...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02768212
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To review the results of management of 42 cases of genitourinary fistulas of obstetric origin. SETTINGS:Department of urology, Nishtar Hospital, Multan, Pakistan. METHODS:Forty two cases of genitourinary fistulas (36 vesicovaginal, 2 vesicouterine, one ureterovaginal and 3 urethrovaginal) were repaired from...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025679205541
更新日期:2002-01-01 00:00:00
abstract::Authors measured the thickness of the basement membranes of the proximal and distal tubuli in the renal cortex in 20 patients with verified diabetes mellitus. The test group consisted of 20 patients with small abnormalities of glomeruli (or in the range of variable norm), of the same sex and comparable age. Measuremen...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550972
更新日期:1996-01-01 00:00:00
abstract::Kidney transplantation provides the best outcome for patients with end-stage renal failure both in terms of morbidity and mortality and health-related quality of life (QoL). Health-related QoL has become recognized as an important outcome measure in patients with different chronic medical conditions, including chronic...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9527-z
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To describe our experience with Hydro-Jet-assisted laparoscopic partial nephrectomy (LPN) with no renal arterial clamping in 35 patients with renal cell carcinoma. METHODS:Hydro-Jet technique was used to incise the renal parenchyma, dissect the intrarenal vessels and collecting system during the LPN procedur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0670-9
更新日期:2014-07-01 00:00:00
abstract::Indications for operation, immediate postoperative morbidity and complications were recorded in 43 patients circumcised with the Plastibell device. Questionnaires were used in recording late postoperative morbidity and complications during the mean observation period of 29 months, and were followed by a clinical and c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550667
更新日期:1988-01-01 00:00:00
abstract::The urethral syndrome is generally not associated clinically with urethral changes, however, histology often reveals inflammatory or degenerative alterations. The conventionally diagnosed urethral syndrome can certainly be considered to be a synonym of chronic urethritis in adult females. The remarkable histological l...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082229
更新日期:1979-01-01 00:00:00
abstract:PURPOSE:The natural history and optimal management strategy for men with human immunodeficiency virus (HIV) and prostate cancer remain to be definitively characterized. This study was conducted to evaluate the clinical characteristics and outcomes of HIV-seropositive men treated with robotic-assisted radical laparoscop...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1338-4
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Frailty is a multicausal syndrome characterized by a decrease in strength, resistance and physiological function, which makes the individual vulnerable and dependent, and increases his/her mortality. This syndrome is more prevalent among older individuals, and chronic kidney disease patients, particularly ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02757-8
更新日期:2021-01-30 00:00:00
abstract:BACKGROUND:Paediatric kidney transplantation has different aspects in adults in terms of underlying primary renal disease, surgical technique, perioperative care and graft prognosis. Significant urological problems are present in a high percentage of paediatric recipients. This study was undertaken to characterize paed...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550558
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Pulmonary hypertension (PH) in maintenance hemodialysis (MHD) patients has attracted increasing attention. This cross-sectional survey aimed to explore PH prevalence and identify potential risk factors in MHD patients. METHODS:A total of 136 MHD patients were assessed at the Fifth Affiliated Hospital of Sun Ya...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1119-5
更新日期:2015-11-01 00:00:00
abstract::Fournier's gangrene (FG) is a rapidly progressive, fulminant infection of the scrotum, perineum and the abdominal wall. FG is caused by synergic aerobic and anaerobic organisms. Modern surgical series report mortality of up to 67%. This originally rare disease has become more frequent. Aggressive treatment including a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019554327341
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate conservative management of renal echinococcosis in cases with normal renal function and active disease. PATIENTS AND METHODS:From a series of 12 consecutive patients with primary renal echinococcosis, nephrectomy was suggested to 4 patients because of kidney destruction. One patient who denied surg...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014405325703
更新日期:2001-01-01 00:00:00