Abstract:
OBJECTIVE:The prostatitis syndrome is a multifactorial condition of largely unknown etiology. This study is to analyze the relationship between cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) with the chronic nonbacterial prostatitis (CNBP). METHODS:A total of 172 CNBP patients and 151 healthy males were recruited as CNBP and control group, respectively. The prostatic fluid was collected and tested by pre- and post-massage test. White blood cell (WBC) number was counted, and the contents of COX-2 and PGE2 were determined by double antibody-based sandwich enzyme-linked immuno-sorbent assay. The pain and discomfort of each patient were scored according to the National Institutes of Health chronic prostatitis symptom index. RESULTS:Compared with the control group, CNBP group displayed significantly higher WBC count, COX-2 level, and PGE2 level. Contents of COX-2 and PGE2 in prostatic secretion of CNBP group were positively correlated with pain scores (r = 0.855 and 0.675, respectively, P < 0.01) and total symptom scores (r = 0.674 and 0.566, respectively, P < 0.01). A significantly positive correlation between COX-2 and PGE2 levels was also discovered (r = 0.493, P < 0.05). The WBC number was not obviously correlated with the accumulations of COX-2 and PGE2 or the clinic symptoms of CNBP. CONCLUSION:Increase in PGE2 concentration caused by activated COX-2 pathway may contribute to the pain or discomfort symptom of the CNBP patients. Our results indicate that selective COX-2 inhibitors have application prospect in CNBP treatment.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Yuan Z,Liu X,Deng W,Lai X,Yan Z,Zheng Rdoi
10.1007/s11255-014-0743-9subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1871-5issue
10eissn
0301-1623issn
1573-2584journal_volume
46pub_type
杂志文章abstract::Eight patients with benign prostatic hypertrophy (BPH), considered as a high risk for an operation because of severe accompanying disease, were treated with a self-retaining intraurethral catheter set. Two patients were judged unfit for operation (one because of severe cardiac failure, the other because of severe resp...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
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abstract::Multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma are uncommon diseases. We report on 2 cases of multiloculated renal cell carcinoma. To our knowledge 16 cases of multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma have been previously descr...
journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract::Prostate cancer coexisting with asymptomatic Paget's disease (osteitis deformans) may be difficult to stage. The skeletal lesions of both prostate cancer and Paget's disease may closely resemble each other, as appearing on imaging. A case of clinically localized prostate cancer coexisting with incidental Paget's disea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019502903833
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abstract::While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, an...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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abstract::A total of 234 patients with chronic glomerulonephritis, detected on the basis of clinical, immunological and pathomorphological criteria, have been examined. A group of 23 chronic glomerulonephritis patients with massive deposits of immunoglobulin A found by immunofluorescent examination, has been separated on the ba...
journal_title:International urology and nephrology
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doi:10.1007/BF02085414
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abstract:PURPOSE:Chronic kidney disease (CKD) is associated with a high incidence of obstructive sleep apnea (OSA). We assessed the effect of continuous positive airway pressure (CPAP) on renal function in patients with CKD and OSA. METHODS:In this retrospective cohort study, 42 patients with Stage 3-5 CKD and OSA were stratif...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
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abstract::The value of fine-needle aspiration biopsy of carcinoma of the prostate and its cytological grading is demonstrated. The grade of morphological differentiation in cytological smears has proved to be a reliable criterion for the prognosis in 496 estrogen-treated prostatic carcinoma patients. The life expectancy of low-...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082472
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journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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journal_title:International urology and nephrology
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abstract::Infertility may occur in patients with unilateral testicular torsion whose contralateral testis is intact. Depending on this observation, the physicians have begun to examine the contralateral testis. In the present prospective study we aimed to examine the histopathologic alterations occurring in the contralateral te...
journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract::Renal blood flow measurements have been carried out by means of positron emission tomography (PET) to facilitate the detection of radiation-induced injuries. The advantages of the method employed in animal experiments are described. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550121
更新日期:1992-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0574-0
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Estimation of the glomerular filtration rate (GFR) is required in the assessment of patients with chronic kidney disease (CKD) in order to provide information regarding the functional status of the kidneys. Current guidelines advocate the use of prediction equations, such as the Cockcroft-Gault (CG) formula ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9515-8
更新日期:2009-01-01 00:00:00
abstract::In a retrospective study of patients treated for germ cell tumours, the authors found seven patients with primary extragonadal tumours in the retroperitoneum. These tumours are, in terms of histology, identical with germ cell tumours of the testis. The disease manifests itself by pain in the kidney region, palpable ab...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549572
更新日期:1988-01-01 00:00:00
abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1083-0
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To review the results of management of 42 cases of genitourinary fistulas of obstetric origin. SETTINGS:Department of urology, Nishtar Hospital, Multan, Pakistan. METHODS:Forty two cases of genitourinary fistulas (36 vesicovaginal, 2 vesicouterine, one ureterovaginal and 3 urethrovaginal) were repaired from...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025679205541
更新日期:2002-01-01 00:00:00
abstract::Considering the aging dialysis population of today, increasing our knowledge about the nature, diagnosis and the treatment of bone mineral density (BMD) problems in end-stage renal disease (ESRD) patients deserves more attention. Osteoporosis is basicly defined as a decrease in bone mass. Large epidemiological studies...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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abstract:PURPOSE:To perform a systematic review and meta-analysis to evaluate the cardiovascular prevention effect of aspirin among patients with chronic kidney disease (CKD). METHODS:A comprehensive literature search was conducted in Embase, PubMed, and Cochrane library (up to March 2019) without language limitations. Randomi...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1583-1
更新日期:2017-07-01 00:00:00
abstract::Twenty patients on home peritoneal dialysis were studied during two years. The patients dialysed 4--5 times a week, using an average of 78 l dialysis fluid. The dialysis equipment used was either a simplified delivery system or a fully automatic dialysis machine. Despite clinical improvement, serum urea and serum crea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081965
更新日期:1979-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
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abstract::The aim of this report is to emphasize the use of methylene staining test and the Nd:YAG laser in the diagnosis and treatment of premalignant lesions and CIS of the bladder. The use of an appropriate solution of methylene blue (0.2% in 0.9 M NaCl for 15 min) permits the staining of premalignant areas and CIS, and thei...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559739
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abstract:AIM:Chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS) is a common disabling condition that is primarily associated with pain in the urogenital region and disturbances in urinary and sexual function. Chronic pelvic pain symptoms are the most common presentation, especially perineal, lower abdominal, testi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9809-5
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更新日期:2017-12-01 00:00:00
abstract:PURPOSE:The purpose of this study was to evaluate the efficacy of tegafur-uracil (UFT) administration as a fourth-line therapy in patients with castration-resistant prostate cancer (CRPC) who had already received combined androgen blockade (CAB) therapy (first-line), alternative antiandrogen therapy (second-line), and ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0634-5
更新日期:2014-06-01 00:00:00
abstract::Observations with diagnostic ultrasound in renal disease over a 10-year period are reviewed. The advantages of diagnostic methods involving the least possible discomfort to the patient are emphasized. Ultrasonography is regarded as a reliable non-invasive method for the diagnostic differentiation between renal tumours...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/BF02083009
更新日期:1983-01-01 00:00:00