Abstract:
PURPOSE:Sodium polystyrene sulfonate (SPS) is a cation-exchanging resin that has been widely used for several decades as first-line therapy of mild chronic hyperkalemia in patients with chronic kidney disease (CKD). However, evidence to prove the long-term tolerability and efficacy of SPS for the treatment of this condition is still missing. METHODS:In this retrospective, observational study, we enrolled 26 outpatients with stages 3-4 CKD who received oral therapy with low-dose SPS for mild chronic hyperkalemia in the Outpatient Nephrology clinic of our Department during 2010-2016. We obtained medical records on side effects potentially attributable to SPS use, and we analyzed the changes in serum electrolytes before and after the initiation of SPS therapy. RESULTS:Serum potassium levels fell from 5.9 ± 0.4 to 4.8 ± 0.5 mmol/l (P < 0.001) over a median follow-up of 15.4 months (range 3-27 months). SPS use was associated with a slight, but significant elevation in serum sodium levels (139.5 ± 2.9 vs 141.2 ± 2.4, P = 0.006), whereas serum calcium and phosphate remained unchanged before and after the initiation of SPS. We recorded ten episodes of recurrent serum potassium elevation ≥ 5.5 mmol/l, none of which required hospitalization or acute dialysis. No episode of colonic necrosis or any other serious drug-related adverse event was observed. SPS therapy was well-tolerated, since only 1 out of 26 patients discontinued SPS at 3 months due to gastrointestinal intolerance. CONCLUSION:This study suggests that low-dose SPS is well-tolerated and can effectively normalize elevated serum potassium over several weeks in CKD outpatients with mild chronic hyperkalemia.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Georgianos PI,Liampas I,Kyriakou A,Vaios V,Raptis V,Savvidis N,Sioulis A,Liakopoulos V,Balaskas EV,Zebekakis PEdoi
10.1007/s11255-017-1717-5subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2217-2221issue
12eissn
0301-1623issn
1573-2584pii
10.1007/s11255-017-1717-5journal_volume
49pub_type
杂志文章abstract::Serum concentrations of carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal parathyroid hormone (C-PTH) were measured in 33 haemodialysis patients. Serum levels of PICP and C-PTH in the haemodialysis group were significantly higher than those in the controls. Although there was no correlation b...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550286
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:In low and middle- income countries, due to lack of financial resources, the number of patients receiving one or two hemodialysis (HD) sessions a week has increased, leading to a large number of complications. Protein-energy wasting (PEW) and overhydration (OH) are common complications; nevertheless, the eviden...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02697-3
更新日期:2021-01-04 00:00:00
abstract:PURPOSE:In this research, the normal anatomy of urethral sphincter complex in young Chinese males has been studied. METHODS:The sagittal, coronal, and axial T2-weighted non-fat suppressed fast spin-echo images of pelvic cavities of 86 Chinese young males were studied. RESULT:Urethral sphincter complex is a cylindrica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0686-1
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:Our aim was to compare the different characteristics and outcomes of the Amplatz sheaths and single-step metallic dilators which were used for mini-PCNL procedure in a single institution. METHODS:Retrospective medical records of 236 patients who underwent mini-PCNL were reviewed and divided into Amplatz (n = 1...
journal_title:International urology and nephrology
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doi:10.1007/s11255-017-1516-z
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the results and complications in 170 patients with symptomatic benign hyperplasia who underwent laser prostatectomy focusing on six month and long-term results. METHODS:A total of 170 patients underwent side firing Neodymium:Yag laser prostatectomy between January 1995 and February 2001 of whom ...
journal_title:International urology and nephrology
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doi:10.1023/a:1025948028530
更新日期:2003-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-011-0053-4
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:We examined renal function and urinary drainage of children with primary megaureter (PMU) in dependence on conservative or operative treatment. MATERIAL AND METHODS:The retrospective analysis covering the years 1994 to 2000 comprised children at an age of 0-7 years with 35 PMU. Sonography, dynamic MAG3 reno...
journal_title:International urology and nephrology
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doi:10.1007/s11255-005-3615-5
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abstract:PURPOSE:The use of interactive voting systems in continuing education helps to evaluate the alteration in the audience's views after a presentation. This study was designed to evaluate whether urologists' attitude towards management of benign prostate hyperplasia can be changed, and to estimate objectively the achievem...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9183-0
更新日期:2007-01-01 00:00:00
abstract::The authors describe a case of ureteral fibroma. The aetiology, clinical symptomatology and diagnosis are discussed, and differentiation between benign and malignant lesions is emphasized. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564752
更新日期:1995-01-01 00:00:00
abstract::Sex cord stromal tumors are rare and account for approximately 6% of all testicular neoplasms. We report a case of sex cord tumor composed of granulosa cells and Sertoli cells in the adult testis. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000022907.66796.61
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) has been identified as a growing global burden and traditional health care systems are inadequate for the management of CKD patients. This paper describes an initiative to establish a renal management clinic (RMC) in China and discusses the challenges and opportunities in the man...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9450-8
更新日期:2008-01-01 00:00:00
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doi:10.1007/s11255-016-1482-x
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0554-4
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doi:10.1007/s11255-019-02185-3
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journal_title:International urology and nephrology
pub_type: 杂志文章
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abstract::Forty-two young men with abacterial prostatitis underwent physical examination, semen analyses, rectal US (TRUS) and magnetic resonance imaging (MRI) of the pelvis. Findings on TRUS showed no distinct differences like capsular irregularity, dilatation of the seminal vesicles and calcified foci in the prostate. In MRI ...
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更新日期:2011-09-01 00:00:00
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journal_title:International urology and nephrology
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doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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abstract::Different methods are available in the diagnosis and treatment of urethral strictures. True diagnosis is necessary for choosing the most suitable method of treatment and to inform the patient about the method, complications, recurrence rate and costs. In this study we aimed to compare the efficiency, complications and...
journal_title:International urology and nephrology
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