Abstract:
INTRODUCTION:The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturition, the circumference of the urinary bladder changes enormously. Thus, FD might be an important phenomenon during smooth muscle contraction. MATERIALS AND METHODS:Electrically stimulated, intact urinary bladder strips from pigs (n = 10) were suspended in an aerated-filled organ bath, and different isometric, isotonic, and isokinetic contraction protocols were performed to determine the force-length and the force-velocity relation. FD and FE were assessed in concentric and eccentric contractions with different ramp lengths and ramp velocities. RESULTS:Bladder smooth muscles exhibit considerable amounts of FD and FE. The amount of FD increased significantly with ramp length, while FE did not change. However, FE and FD were independent of ramp velocity. CONCLUSION:The results imply that smooth muscle bladder strips exhibit similar muscle properties and history-dependent behaviour compared to striated muscles. The provided dataset of muscle properties is important for bladder modelling as well as for the analyses and interpretation of dynamic bladder filling and voiding.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Menzel R,Böl M,Siebert Tdoi
10.1007/s11255-016-1482-xsubject
Has Abstractpub_date
2017-02-01 00:00:00pages
205-214issue
2eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1482-xjournal_volume
49pub_type
杂志文章abstract:BACKGROUND:According to the concept of integrated care, renal transplantation, peritoneal dialysis (PD), and hemodialysis (HD) should be considered three complementary methods of renal replacement therapy. This study tried to evaluate patient outcomes in three different groups of PD patients, namely primary PD patients...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
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abstract:PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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abstract::We report a 40-year-old lady who presented with severe headaches, persistent microscopic haematuria and hypertension requiring anti-hypertensive medication. Investigations for secondary hypertension were all normal except for a CT scan. This indicated a complex cystic lesion, measuring 2.4 x 5 x 10 cms , arising from ...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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