Abstract:
:Type 2 diabetes mellitus (DM2) is a chronic condition that affects more than 400 million individuals worldwide. In DM2 patients, an appropriate glycemic control slows the onset and delays the progression of all its micro and macrovascular complications. Even though there are several glucose-lowering drugs, only approximately half of patients achieve glycemic control, while undesirable adverse effects (e.g., low serum glucose) normally affect treatment. Therefore, there is a need for new types of treatments. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have just been developed for treating DM2. Renal hyperfiltration as a marker of increased intraglomerular pressure in diabetic patients, and the role of renin-angiotensin-aldosterone system (RAAS) in this phenomenon have been studied. Nevertheless, RAAS blockade does not completely reduce hyperfiltration or diabetic renal damage. In this sense, the contribution of renal tubular factors to the hyperfiltration state, including sodium-glucose cotransporter (SGLT), has been currently studied. SGLT2i reduce proximal tubular sodium reabsorption, therefore increasing distal sodium delivery to the macula densa, causing tubule-glomerular feedback activation, afferent vasoconstriction, and reduced hyperfiltration in animal models. In humans, SGLT2i was recently shown to reduce hyperfiltration in normotensive, normoalbuminuric patients suffering from type 1 diabetes mellitus. In DM2 clinical trials, SGLT2 is associated with significant hyperfiltration and albuminuria reduction. The aim of this article is to compile the information regarding SGLT2i drugs, emphasizing its mechanism of renal repercussion.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Castañeda AM,Dutra-Rufato A,Juarez MJ,Grosembacher L,Gonzalez-Torres H,Musso CGdoi
10.1007/s11255-020-02585-wsubject
Has Abstractpub_date
2020-08-07 00:00:00eissn
0301-1623issn
1573-2584pii
10.1007/s11255-020-02585-wpub_type
杂志文章,评审abstract:OBJECTIVE:To assess the effectiveness of stepwise extracorporeal shock wave lithotripsy in the treatment of upper urinary stones in childhood. PATIENTS AND METHODS:Between August 1998 and August 2003, 31 patients were treated for renal or ureteric stones. All treatments were performed with Dornier Compact Delta lithot...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-005-4971-x
更新日期:2006-01-01 00:00:00
abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation betwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1228-9
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:Timely risk assessment of chronic kidney disease (CKD) and proper community-based CKD monitoring are important to prevent patients with potential risk from further kidney injuries. As many symptoms are associated with the progressive development of CKD, evaluating risk of CKD through a set of clinical data of s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1346-4
更新日期:2016-12-01 00:00:00
abstract::Artificial insemination (ADI) has been carried out with donor semen since 1984. Following artificial insemination 14 women out of 27 became pregnant in 1984, 30 women out of 57 in 1985 and 33 women out of 56 until October 1, 1986. The cycles were monitored. Serum LH and oestradiol levels were determined every day from...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549573
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6657-4
更新日期:2006-01-01 00:00:00
abstract::To enlarge bladder capacity after extensive segmental bladder resection, the authors sutered bladder margins to the serosal aspect of intact sigmoid (Heeg's method). Experimental data and two clinical cases have proved this technique to be of practical value. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082674
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVES:Metformin has been shown to reduce diabetic complications in overweight patients, and is increasingly used to treat this condition. However, this agent is associated with a rare but serious risk of lactic acidosis. METHODS:From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9549-6
更新日期:2009-12-01 00:00:00
abstract::We report a case of spontaneous perirenal hematoma that developed acutely during an elective coronary angiography in a 65-year-old man with suspected coronary artery disease, probably related to the use of heparin during angiography. The patient did not have any systemic vasculitides and was not receiving antiplatelet...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025982613830
更新日期:2003-01-01 00:00:00
abstract::Multiple myeloma is characterized by marrow plamacytsois, M spike in serum or urine electrophoresis and skeletal lytic lesions. The M spike may be absent in rare instances. We describe a case of myeloma cast nephropathy with acute renal failure who did not exhibit an M spike. lambda-chain staining was documented on im...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-004-2362-3
更新日期:2005-01-01 00:00:00
abstract::A total of 234 patients with chronic glomerulonephritis, detected on the basis of clinical, immunological and pathomorphological criteria, have been examined. A group of 23 chronic glomerulonephritis patients with massive deposits of immunoglobulin A found by immunofluorescent examination, has been separated on the ba...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085414
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the new medical device Transurethral Suprapubic endo-Cystostomy (T-SPeC(®)), used for suprapubic catheter (SPC) placement via the transurethral (inside-to-out) approach, and examine the 30-day outcomes in the first US series. METHODS:IRB approval was obtained for this prospective s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0884-x
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Chronic kidney disease (CKD) is a major public health problem worldwide, due to its epidemic proportions and to its association with high cardiovascular risk. Therefore, screening for CKD is an increasingly important concept, aiming for early detection and prevention of progression and complications of thi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9923-z
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:To evaluate the possible association between metabolic syndrome (MetS) and infectious complications after prostate biopsy. METHODS:A total of 480 men underwent prostatic biopsy due to elevated prostate-specific antigen levels and/or abnormal digital rectal examination. Patients were divided into two subgroups ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0904-x
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:To survey long-term outcomes of dialysis patients with urothelial cancers who have undergone complete urinary tract exenteration (bilateral nephroureterectomy and cystectomy). METHODS:We retrospectively reviewed our patients with urinary tract urothelial cancer. Forty-two dialysis patients who underwent comple...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1522-1
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To evaluate all possible risk factors that can cause impairment of overall renal function in patients with unilateral ureteral calculus and a normal contralateral kidney. METHODS:This is a prospective study of 90 patients who presented to our institute complaining of renal colic secondary to unilateral urete...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-0986-0
更新日期:2015-07-01 00:00:00
abstract::The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
abstract::The present study demonstrated prolonged decreases of phagocytic activity by neutrophils in comparison to transitory neutropenias during haemodialysis with cuprophane membranes, remaining in connection with non-equalization immunological findings as C3 complement levels, circulating immune complexes and lysozyme activ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559638
更新日期:1989-01-01 00:00:00
abstract::Cardiovascular disease (CVD) begins early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with CKD. Preventing the development of CVD and establishing new clinical tools for identifying high-risk individuals, particularly those with an increased risk for cardiac death, is of...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0421-3
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Limited numbers of literatures have focused on the association between γ-glutamyltransferase (GGT) and chronic kidney disease (CKD), and their results were controversial. Therefore, in this study, we set up a large-scale cohort of Chinese population to discover and verify the association between serum GGT and C...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1429-2
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1633-8
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The use of anabolic steroids and vitamin supplements has reached alarming proportions in the last decades. Adverse effects have been documented and include virilization, feminization, adverse lipid profile, psychiatric disorders, cardiac and liver disease. Acute kidney injury (AKI) is not frequently describe...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9571-8
更新日期:2009-01-01 00:00:00
abstract::Recipients of renal allografts are surviving longer and, consequently, may experience a variety of complications related not only to the transplanted kidney, but also to the hematopoietic system. Common hematologic complications in the renal transplant patient include abnormalities of one cell line, such as post-trans...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9558-5
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is emerging as a predictor of poor stroke outcome, however, it is often not recognized. The aim of our study was to evaluate post-stroke AKI burden, AKI risk factors and their influence in post-stroke outcome. METHODS:From 2013 to 2016, 440 individuals with stroke diagnosis admitte...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02203-4
更新日期:2019-09-01 00:00:00
abstract::Forty-two young men with abacterial prostatitis underwent physical examination, semen analyses, rectal US (TRUS) and magnetic resonance imaging (MRI) of the pelvis. Findings on TRUS showed no distinct differences like capsular irregularity, dilatation of the seminal vesicles and calcified foci in the prostate. In MRI ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550227
更新日期:1998-01-01 00:00:00
abstract::Percutaneous renal biopsy is a fundamental diagnostic technique. Technical innovations had resulted in an increasing simplicity and safety of the procedure. In this study, 28 kidney biopsies were done using gauge 16 or 18 automated biopsy needle by inexperienced trainees, and patients were allowed full ambulation four...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02550217
更新日期:1998-01-01 00:00:00
abstract::We have documented the data of squamous metaplasia of the bladder in 14 patients who had undergone cystoscopies for different reasons. In two biopsies, there were marked keratinization and cellular atypia. One of these two subjects was diagnosed as squamous carcinoma of the prostate and transitional cell carcinoma of ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007107110222
更新日期:1999-01-01 00:00:00
abstract:AIMS:Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED. METHODS:We designed a strate...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-017-1644-5
更新日期:2017-10-01 00:00:00
abstract::Chronic renal failure is a risk factor for tuberculosis. In the past five years we have identified two cases of tuberculosis in our dialysis population. The first patient, showed chronic failure to thrive on hemodialysis. An enlarged cervical lymph node was biopsied and, although no acid fast bacilli (AFB) were seen, ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1007108809773
更新日期:2000-01-01 00:00:00
abstract::A modified method of retropubic radical prostatectomy was devised. The root of the penis was compressed and the bilateral internal iliac arteries were clamped before the dissection of the prostate. The urethra was divided at the junction of the prostate and bladder so that the bladder stump thus created has the size o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549537
更新日期:1992-01-01 00:00:00