Abstract:
PURPOSE:Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation between the changes of ghrelin system in hippocampus and the spatial cognitive impairment caused by chronic renal failure (CRF). METHODS:Sprague-Dawley rats (male, 180 ± 10 g, 7-8 weeks old) were randomly classified into CRF group and control group (n = 18 per group). The CRF model was constructed by 5/6 nephrectomy and the controls treated with sham operation. By the 8th week after the surgery, the spatial cognitive function of rats was assessed by Morris water-maze test (MWM), the protein expression of ghrelin and GHS-R in the hippocampus by immunohistochemistry, and the mRNA expression by real-time PCR. Statistical analysis was performed using ANOVA, Student-Newman-Keuls-q test and Pearson correlation analysis, and P < 0.05 was considered significant. RESULTS:Compared with the controls, the time spent in "platform" quadrant (TSPQ) of rats with CRF was decreased, but the escape latency (EL) was increased significantly in MWM, and meanwhile the protein and mRNA expression of ghrelin and GHS-R in hippocampus was also increased significantly (P < 0.05 or P < 0.01). Correlation analysis suggested that the TSPQ was negatively but the EL was positively correlated with the mRNA expression of ghrelin and GHS-R (P < 0.01). CONCLUSION:The CRF-caused changes of ghrelin system in hippocampus might be correlated with the CRF-caused cognitive function impairment.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Lv Z,Gao J,Wang L,Chen Z,Yuan H,Ma X,Lu J,Lv J,Wu X,Zhang L,Wei L,Xue R,Fu R,Ma Ldoi
10.1007/s11255-016-1228-9subject
Has Abstractpub_date
2016-05-01 00:00:00pages
807-15issue
5eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1228-9journal_volume
48pub_type
杂志文章abstract::Genitourinary organs are at greater risk for multiple primary malignant neoplasms because of the high incidence of these tumours as primaries among all other organs. We present a case of prostate and bladder carcinoma metastasized to a single pelvic lymph node, called a "collision" metastasis, in a patient with four p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552140
更新日期:1995-01-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels. METHODS:The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007142910479
更新日期:2000-01-01 00:00:00
abstract::Lowering dietary protein intake (DPI) to approximately 0.6-0.8 g/kgBW/day may be renoprotective through various mechanisms, and it has been recommended in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) as a means to also control various metabolic consequences of advanced CKD, such as uremic symp...
journal_title:International urology and nephrology
pub_type: 社论
doi:10.1007/s11255-016-1224-0
更新日期:2016-05-01 00:00:00
abstract::Patients with metastatic prostate cancer respond to androgen withdrawal therapy, but progression to androgen independence is frequently observed. To clarify the predictor of response to endocrine therapy, the role of PSA changes and the prognosis of the patients were evaluated in 115 Japanese cases of prostate cancer ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014410026495
更新日期:2001-01-01 00:00:00
abstract::In the course of a disinterment of an ancient Avar burial place at Székkutas-Kápolna near Hódmezövásárhely, Hungary, the archaeologist conducting the excavations, Miss Katalin B. Nagy, noticed a lithoid body of oval shape in the pelvis of a skeleton. The find was identified on morphological and chemo-analytical ground...
journal_title:International urology and nephrology
pub_type: 历史文章,杂志文章
doi:10.1007/BF02550466
更新日期:1987-01-01 00:00:00
abstract::In our center between 1992 and 1994 penile Mondor's disease (superficial dorsal penile vein thrombosis) was diagnosed in 5 patients aged 20-39 years. In all patients the thromboses were noted 24-48 hours after a prolonged sexual act with or without an intercourse. the main symptom was a cord-like thickening of the sup...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550502
更新日期:1996-01-01 00:00:00
abstract::The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
abstract::Disturbances in purine metabolism with hyperuricaemia and/or hyperuricosuria are a risk factor in uric acid and Ca oxalate stone formation. By way of a competitive xanthine oxidase inhibition, the formation of uric acid is reduced by allopurinol. In investigations on two groups of patients, Milurit could be demonstrat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085441
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To compare the antibiotic prophylaxis based on quinolone administered orally with a combination of cephalosporin administered periprostatically and a fluoroquinolone orally, in terms of post-prostate bioptic infectious complication rates in those men undergoing transrectal ultrasound-guided prostate biopsy (TRU...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-012-0160-x
更新日期:2012-08-01 00:00:00
abstract::The results of treatment by means of modified RLND in 52 patients with clinical stage I non-seminomatous testicular cancer are presented. Retroperitoneal lymph node metastases were found in 15 patients (28.8%) with clinical stage I (CS-I) diagnosed prior to surgery. They received chemotherapy according to PVB schedule...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768020
更新日期:1994-01-01 00:00:00
abstract::We present a case of migration of the left renal vein (LRV) stent into the right ventricle in a patient with nutcracker syndrome. After a failed attempt of percutaneous endovascular removal of the stent, the stent in the heart was removed by open cardiac surgery, another stent was placed into the LRV via a puncture in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9478-9
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Reusable flexible-ureteroscopes (fURS) require personnel and budget for processing and repairing, whereas single-use fURS were recently developed. After exclusive reusable fURS since 2011, we experienced high repair costs and single-use fURS were therefore introduced in mid-2017. We aimed to evaluate economic a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02230-1
更新日期:2019-10-01 00:00:00
abstract::During a 3-year period, hundreds of patients underwent ESWL treatment with the Dornier HM-3 and HM-4 lithotriptors operating at our institution. Our experience in 3,500 patients treated with the HM-4 bath-free lithotriptor is reported. Patients with radiolucent or cystine stones, stones larger than 3 cm or staghorn ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551334
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the effect of a modified technique for peritoneal dialysis catheter placement in the right lower quadrant with respect to catheter tip migration. METHODS:This retrospective study included 237 patients with end-stage renal disease who underwent implantation of a two-cuff...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0899-3
更新日期:2015-03-01 00:00:00
abstract::The objective of this study was to evaluate the prognostic factors and role of nephrectomy in metastatic renal cell carcinoma. We reviewed 62 cases of metastatic renal cell carcinoma (RCC) at presentation to document the factors influencing the survival and to evaluate the role of nephrectomy. Sex and age of the patie...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564853
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:ADPKD is one of the most common inherited disorders, with high risk for end-stage renal disease. Numerous patients, however, have no relatives in whom this disorder is known and are unsure whether they may transmit the disease to their offsprings. The aim of this study was to evaluate whether germline mutati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0125-0
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Non-adherence (NA) to medication is a major contributor to treatment failure in hypertensive patients. Factors of the ecological model, at family/healthcare professional, service, and system levels, are rarely evaluated as correlates of NA in hypertensive patients. METHODS:This crossectional study assessed the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02755-w
更新日期:2021-01-16 00:00:00
abstract::The safety and histopathologic effects of polytetrafluoroethylene (Gore-Tex) grafts in reconstruction of the urinary bladder were examined. Following partial excision of the bladder Gore-Tex was placed, and the rats were sacrificed at days 7, 14 and 30. Gore-Tex did not cause urine infection, and there was no peritoni...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007117917974
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1835-8
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Surgical removal of completely endophytic renal tumors has presented great technical difficulties for surgeons. In this study, we aim to introduce the role and use of intraoperative ultrasound (IOUS) performed in robotic-assisted renal partial nephrectomy (RAPN) for endophytic renal tumors. METHODS:We retro...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02664-y
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:Bone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease (CKD). Sclerostin, a novel candidate protein, has been identified to be involved in the bone-vascular axis. The aims of the current investigation were to assess vessel sclerostin expression and...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1604-0
更新日期:2017-08-01 00:00:00
abstract::This study was designed to investigate the relationship between the effects of testicular reactive oxygen species (ROS) levels and testicular histology on infertile patients with the aid of xanthine oxidase system and testicular tissue malondialdehyde levels. Forty patients with idiopathic infertility constituted our ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007138522517
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract::We report a case of penile incarceration in a 53-year-old impotent man. The base of the penis was encircled by a metal ring in order to achieve better erection. There was marked oedema of the entire penis distal to the constricting ring. The metal ring was removed successfully by cutting it with a steel saw. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564752
更新日期:1995-01-01 00:00:00
abstract::Serum renin concentration (SRC) was determined in 97 hypertensive patients under basal conditions and during stimulation of renin secretion. Renin secretion was stimulated by upright posture and by either of the following means: (a) diet containing 20 mEq Na/24 hours for 3 days; (b) 300 mg i.v. diazoxide injections; (...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082246
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:The authors aimed to establish a rat model of catheter-associated UTIs using a complete urethral catheter. Bacterial growth in biofilms on urethral catheters was analyzed using standard culture methods to validate this model. METHODS:A total of 15 rats were divided into the following three groups according to ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1038-5
更新日期:2015-08-01 00:00:00
abstract:AIMS:Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED. METHODS:We designed a strate...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-017-1644-5
更新日期:2017-10-01 00:00:00
abstract::Peripheral PRA was examined in 11 patients with graft artery stenosis after the onset and throughout the course of hypertension. In the acute stage PRA was elevated in 9 patients and decreased to normal in the later stage of hypertension in all but 1 patient with malignant hypertension. The findings suggest that the d...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082428
更新日期:1981-01-01 00:00:00
abstract::Authors report on a case of Pseudomonas prostatitis complicated with a prostatoperineal fistula in continuity with the urethra that has been successfully treated with human fibrin sealant (Tissucol). ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564742
更新日期:1995-01-01 00:00:00