The significance of testicular reactive oxygen species on testicular histology in infertile patients.

Abstract:

:This study was designed to investigate the relationship between the effects of testicular reactive oxygen species (ROS) levels and testicular histology on infertile patients with the aid of xanthine oxidase system and testicular tissue malondialdehyde levels. Forty patients with idiopathic infertility constituted our study group. Bilateral testicular biopsies were performed and spermatogenesis was assessed histopathologically. Patients were divided into 4 groups according to spermatogenic pattern (normal spermatogenesis; hypospermatogenesis; maturation arrest; Sertoli cell only syndrome). Testicular tissue xanthine oxidase and malondialdehyde (MDA) concentrations were analyzed in each sample by spectrophotometric assay and thiobarbituric acid reaction assay, respectively. Testicular tissue MDA and xanthine oxidase concentrations were not statistically different in patients having normal spermatogenesis, with respect to Sertoli cell only syndrome, maturation arrest and hypospermatogenesis, respectively. As a result of our study we think that there are still some factors other than ROS which may be important contributors to spermatogenetic injury that need to be examined.

journal_name

Int Urol Nephrol

authors

Yaman,Soygür T,Yilmaz E,Elgün S,Keskineğe A,Göğüş O

doi

10.1023/a:1007138522517

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

395-9

issue

3

eissn

0301-1623

issn

1573-2584

journal_volume

31

pub_type

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