Abstract:
OBJECTIVES:Metformin has been shown to reduce diabetic complications in overweight patients, and is increasingly used to treat this condition. However, this agent is associated with a rare but serious risk of lactic acidosis. METHODS:From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis were seen at a medical center in Taiwan. The patients' records were retrospectively reviewed with respect to clinical presentation, biochemical data, therapeutic strategies, and outcomes. RESULTS:Ten out of 11 patients with acute kidney injury were enrolled in this study. From their pre-existing states, these patients would have been considered at low risk of developing lactic acidosis. However, all of them had acute intercurrent conditions that might compromise renal function. Among them, six patients were ventilated and five patients had severe hypotension with vasoactive support. Nine patients received renal replacement therapy to clear the acidosis and treat the renal failure. All but one of our patients survived. Recovery of renal function was the general rule in survivors. CONCLUSIONS:Metformin-associated lactic acidosis is commonly accompanied with acute kidney injury. In spite of the severity of their illness, the outcome is favorable with intensive support of the cardiovascular, respiratory, and renal systems.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Wen YKdoi
10.1007/s11255-009-9549-6subject
Has Abstractpub_date
2009-12-01 00:00:00pages
967-72issue
4eissn
0301-1623issn
1573-2584journal_volume
41pub_type
杂志文章abstract::A male with a severe form of congenital nephrogenic diabetes insipidus (diuresis 10 l per day) had megaureters, megavesica, large residuum and a history of three traumatic ruptures of the megavesica and a recurrent urinary tract infection (RUTI). Hemodialysis was introduced at 41 years of age. At age of 42, he underwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-0093-3
更新日期:2006-01-01 00:00:00
abstract::During a 3-year period, hundreds of patients underwent ESWL treatment with the Dornier HM-3 and HM-4 lithotriptors operating at our institution. Our experience in 3,500 patients treated with the HM-4 bath-free lithotriptor is reported. Patients with radiolucent or cystine stones, stones larger than 3 cm or staghorn ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551334
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:To evaluate the surgical feasibility and postoperative cosmesis of a novel transumbilical laparoendoscopic single-site (LESS) surgical approach involving Y-shaped incisions and three-flap umbilicoplasty in urachal remnant patients. METHODS:Patients with symptomatic urachal remnants who underwent either convent...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02746-x
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the impact of obesity on clinicopathological features and biochemical recurrence (BCR) following radical prostatectomy (RP) in Korean prostate cancer (PCa) patients. METHODS:A single-institutional retrospective analysis was performed on 880 PCa patients treated by RP ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0729-7
更新日期:2014-10-01 00:00:00
abstract::In this report serum apolipoprotein A I (Apo A I) and apolipoprotein B (Apo B) levels were determined in children with chronic renal disease (CRD) during metabolic acidosis, after the correction of metabolic acidosis and in healthy children to look for the effect of metabolic acidosis on Apo A I and B levels. It was f...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552208
更新日期:1997-01-01 00:00:00
abstract::Investigating the reliability of using some clinical and laboratory parameters as long-term prognostic factors in properly selected patients for stress urinary surgery could help in the prediction of the long-term result in each case. Toward this goal 51 women were examined prospectively, after they were assessed by c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02575219
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is an adverse consequence of contrast media use that results in significant morbidity and mortality and adds significant costs to diagnostic and interventional cardiology procedures. Various pathophysiological mechanisms have been proposed for CIN and various agents have be...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-011-0053-4
更新日期:2012-08-01 00:00:00
abstract::Methylene blue (MB) alone, MB metabolites in the urine and the effect of MB plus alkalization on Candida species were determined. MB was used for the treatment of childhood renal candidiasis (CRC) in 3 patients as an irrigating solution. Besides irrigation, fluconazole 3 mg/kg/day intravenously and MB 0.2 mg/kg/day we...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550565
更新日期:1998-01-01 00:00:00
abstract::We report a case of spontaneous perirenal hematoma that developed acutely during an elective coronary angiography in a 65-year-old man with suspected coronary artery disease, probably related to the use of heparin during angiography. The patient did not have any systemic vasculitides and was not receiving antiplatelet...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025982613830
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the effect of a modified technique for peritoneal dialysis catheter placement in the right lower quadrant with respect to catheter tip migration. METHODS:This retrospective study included 237 patients with end-stage renal disease who underwent implantation of a two-cuff...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0899-3
更新日期:2015-03-01 00:00:00
abstract::This is the first prospective study to investigate the association between kidney stones, bone mineral density, serum testosterone, colon cancer and O. formigenes colonization. 40 kidney stone patients and 85 controls were enrolled. O. formigenes colonization was established. BMD was examined from T- and Z-scores usin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02627-3
更新日期:2021-01-01 00:00:00
abstract::Cardiovascular disease (CVD) begins early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with CKD. Preventing the development of CVD and establishing new clinical tools for identifying high-risk individuals, particularly those with an increased risk for cardiac death, is of...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0421-3
更新日期:2014-01-01 00:00:00
abstract::A surgical case of coexisting renal cyst and tumour is reported, diagnosis having been made preoperatively with the aid of two recent diagnostic procedures. Electron microscopic study of the surgical specimen revealed virus-like intranuclear particles in the malignant tissue. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081944
更新日期:1977-01-01 00:00:00
abstract:PURPOSE:To evaluate whether urine transforming growth factor-β1 (TGF-β1) can help identifying kidneys that would recover their function after drainage of unilateral ureteric obstructive. METHODS:Forty-five patients with unilateral ureteral obstruction were included. Glomerular filtration rate (GFR) of the obstructed k...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0846-3
更新日期:2015-01-01 00:00:00
abstract::A new method of one-stage surgical correction of distal to penoscrotal hypospadias is described. The chordee is released by skin lysis alone and urethroplasty is done by the flip-flap technique while the globular glans is rerolled over the new urethra, all in one stage. The complication rate was minimal (15 per cent),...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082566
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease mineral and bone disorders (CKD-MBD) suffer high rates of morbidity and mortality, in particular related to bone and cardiovascular outcomes. The management of CKD-MBD remains challenging. The objective of this systematic survey is to critically appraise clinical practice...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-016-1436-3
更新日期:2017-02-01 00:00:00
abstract::Megaureter and ureteropelvic junction obstruction are not uncommon urinary tract congenital abnormalities. While each has been known to be associated with other urogenital anomalies, their association together is rarely reported. This report will describe the diagnosis and management of such a case. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02083010
更新日期:1983-01-01 00:00:00
abstract::Apelin, a newly discovered adipocytokine, is produced by white adipose tissue and also expressed in kidney and heart. Increasing evidence suggests a role for apelin in the pathology of the cardiovascular system. It was demonstrated that apelin may contribute to the pathophysiology of human chronic heart failure. Apeli...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9667-1
更新日期:2011-03-01 00:00:00
abstract::In our center between 1992 and 1994 penile Mondor's disease (superficial dorsal penile vein thrombosis) was diagnosed in 5 patients aged 20-39 years. In all patients the thromboses were noted 24-48 hours after a prolonged sexual act with or without an intercourse. the main symptom was a cord-like thickening of the sup...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550502
更新日期:1996-01-01 00:00:00
abstract:AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examin...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-008-9408-x
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Sodium polystyrene sulfonate (SPS) is a cation-exchanging resin that has been widely used for several decades as first-line therapy of mild chronic hyperkalemia in patients with chronic kidney disease (CKD). However, evidence to prove the long-term tolerability and efficacy of SPS for the treatment of this cond...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1717-5
更新日期:2017-12-01 00:00:00
abstract::Silicon transfers were examined during haemodialysis (HD) in 120 chronic HD patients who received 5-hour dialyses 3 times a week. Si levels were measured by flameless atomic absorption spectrophotometry. Ultrafiltrable Si levels approximately equalled dialysate Si levels. Serum Si levels before HD significantly increa...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549799
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:Hypovitaminosis D is common in chronic kidney disease (CKD) and is associated with endothelial dysfunction and cardiovascular events. This study aimed to investigate the effects of vitamin D supplementation on endothelial dysfunction in non-dialysis CKD patients. MATERIALS AND METHODS:Seventy-one non-dialysis ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1829-6
更新日期:2018-05-01 00:00:00
abstract::A case of spontaneous rupture of the renal pelvis is very rare and unusual occurrence. Our case was a young woman who did not present with any disease that was a factor for pelvic rupture. The diagnosis was confirmed by abdominopelvic CT, and emergency repair of the renal pelvis was performed and a ureteral stent was ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9020-x
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To examine whether platelet-to-lymphocyte ratio (PLR) is associated with 5-year mortality in patients with chronic kidney disease (CKD), we performed this study using data from the National Health and Nutrition Examination Survey (NHANES) through 1999 to 2006. METHODS:3285 patients with CKD stage 1-5 were incl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02548-1
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Chronic hepatitis B virus (HBV) carrier status has a critical impact on clinical management of patients with IgA nephropathy (IgAN) who are treated with corticosteroids, because corticosteroids may enhance HBV replication. This study compared corticosteroids and antivirals combined therapy with corticosteroid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0480-5
更新日期:2014-01-01 00:00:00
abstract::A unilateral adrenal tumour was incidentally detected in a 39-year-old woman with no characteristic features of Cushing's syndrome. Basal levels of glucocorticoids were within normal limits. However, abnormal pattern of plasma cortisol and ACTH was observed. The dexamethasone suppression test and the metyrapone test s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Testicular blood flows during unilateral testicular torsion were measured by Xenon-133 clearance technique. Xenon-133 was injected via the left carotid artery into the heart. Measurements were performed in control and left-sided testicular torsion groups, each consisting of ten rats. Left and right testicular blood fl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550119
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Parental iron is used to optimize hemoglobin and enhance erythropoiesis in end-stage renal disease along with erythropoietin-stimulating agents. Safety of iron has been debated extensively and there is no definite evidence whether parenteral iron increases the risk of infections and mortality. We performed t...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02273-4
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:A region of chromosome 22 which includes APOL1 and MYH9 genes was recently identified as a risk locus for non-diabetic forms of kidney disease, including idiopathic and HIV-associated focal segmental glomerular sclerosis and kidney disease clinically attributed to hypertension among African Americans. The purpo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0263-4
更新日期:2013-04-01 00:00:00