Abstract:
AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examination, photographs, and penile USG, before and after therapy. All patients were treated with TEA of the combination of verapamil and dexamethasone. The treatment plan included a total of 20 sessions (at 3-day intervals for a period of 2 months), each with a duration of 20 min. At the end of the study, improvements in penile plaques, penile deviation, pain on erection, and erectile dysfunction were determined. RESULTS:The findings in 41 of the 51 patients were eligible to present. Median patient age was 52 years. Median duration of disease at presentation was 8 months. Remarkable reduction in palpable plaques and in penile angulation was observed in 10 patients (24%) and 11 (26%) patients, respectively. There were significant decreases in median plaque volume from 72 mm(2) to 45 mm(2) (P < 0.001), and in median penile angulation from 25 degrees to 15 degrees (P < 0.001). Impaired sexual activity and pain on erection had completely resolved in 11 (55%) patients and in 16 (80%), respectively. CONCLUSION:The results of our study have shown that TEA of the combination of verapamil and dexamethasone is a more effective therapy for improving subjective symptoms rather than objective symptoms. Therefore, we think that this treatment can be individualized according to the clinical features of PD patients.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Tuygun C,Ozok UH,Gucuk A,Bozkurt IH,Imamoglu MAdoi
10.1007/s11255-008-9408-xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
113-8issue
1eissn
0301-1623issn
1573-2584journal_volume
41pub_type
临床试验,杂志文章abstract:PURPOSE:In the present study we have performed a correlation of the most prevailing clinical conditions of multiple sclerosis (MS) with overall drug response and the grade of the disease. MATERIALS AND METHODS:One hundred and ten patients were consecutively and prospectively studied with a clinical syndrome of MS, ran...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017597016622
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Recently, there have been a few reports on the decrease in the incidence of severe Henoch-Schönlein purpura nephritis (HSPN) in Japan. To evaluate the incidence and the severity of HSPN, we examined the epidemiology and clinical manifestations of HSPN in Fukushima Prefecture over a 22-year period. METHODS:W...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9701-3
更新日期:2010-12-01 00:00:00
abstract::Neurofibromatosis of the urinary tract is estimated to account for 20 per cent of the visceral manifestations of the generalized disease. Among its urological forms involvement of the bladder is the most common. Clinically, neurofibromatosis resembles a tumour, therefore, its early histologic diagnosis is of utmost im...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02089403
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:In low and middle- income countries, due to lack of financial resources, the number of patients receiving one or two hemodialysis (HD) sessions a week has increased, leading to a large number of complications. Protein-energy wasting (PEW) and overhydration (OH) are common complications; nevertheless, the eviden...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02697-3
更新日期:2021-01-04 00:00:00
abstract::Segmental cystectomy or total cystectomy was performed in 26 patients with newly diagnosed stage T1, grade 3 transitional cell carcinoma of the bladder. Their histological specimens were assessed with regard to types of tumour cell spread, small vessel involvement and coexistent carcinoma in situ. Patients were follow...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550418
更新日期:1991-01-01 00:00:00
abstract::Hugely dilated kidneys can sometimes present as abdominal masses. These kidneys are invariably non-functioning and are managed by nephrectomy. We describe a case of massive kidney containing 12.5 litres on fluid which was managed by retroperitoneoscopic nephrectomy. The patient was a 24-year-old male who presented wit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007139613615
更新日期:2000-01-01 00:00:00
abstract::A modified method of retropubic radical prostatectomy was devised. The root of the penis was compressed and the bilateral internal iliac arteries were clamped before the dissection of the prostate. The urethra was divided at the junction of the prostate and bladder so that the bladder stump thus created has the size o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549537
更新日期:1992-01-01 00:00:00
abstract::Kidney injury molecule-1 (KIM-1) staining has been shown to be very useful in identifying acute proximal tubular injury, but its sensitivity, specificity and predicting values for the recovery of renal function after injury in renal biopsies have not been well established. In the first study, we randomly selected 184 ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02311-1
更新日期:2019-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-019-02235-w
更新日期:2019-10-01 00:00:00
abstract::El-Far and Sobh were the first to describe abnormalities in porphyrin metabolism in Egyptian patients with chronic renal failure (CRF). Our results were confirmed by others. The present investigation aims to study and discuss the nature of those abnormalities and changes in porphyrin metabolism in CRF patients followi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02583996
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The association between crescents and renal outcomes was inconsistent in a Chinese IgA nephropathy (IgAN) cohort, and limited research has investigated the prognosis of IgAN patients with crescents. METHODS:Between January 2008 and January 2013, 169 consecutive IgAN patients with crescents in the Xijing Hospit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02457-3
更新日期:2020-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-02070-5
更新日期:2019-03-01 00:00:00
abstract::Primary squamous cell carcinoma of seminal vesicle is extremely rare, and most cases regarding seminal vesicle tumors failed to address this kind of tumor. A 54-year-old male patient presented with intermittent painless visual hematuria for 6 months was hospitalized. Ultrasonography, computerized tomography and magnet...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0373-z
更新日期:2013-02-01 00:00:00
abstract:PURPOSE:Chronic kidney disease (CKD) is associated with a high incidence of obstructive sleep apnea (OSA). We assessed the effect of continuous positive airway pressure (CPAP) on renal function in patients with CKD and OSA. METHODS:In this retrospective cohort study, 42 patients with Stage 3-5 CKD and OSA were stratif...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1113-y
更新日期:2015-11-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0070-3
更新日期:2012-08-01 00:00:00
abstract::A total of 32 female patients with urinary stress incontinence who underwent a Stamey endoscopic bladder neck suspension were clinically and urodynamically studied pre- and postoperatively. Complete cure was obtained in 78% of the patients and improvement in 6%, the overall success rate being 84% for a mean follow-up ...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02768212
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:The present study aimed to evaluate the impact of a filmed research-based drama-Fit for Dialysis-and an exercise program on patients' physical activity and fitness outcomes. METHODS:Nineteen (10 at the intervention site, 9 at the control site) older patients with a medical diagnosis of hemodialysis-dependent e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02745-y
更新日期:2021-01-02 00:00:00
abstract::In 21 men suffering from acute or chronic epididymitis who underwent scrotal surgical exploration, diagnostic microbiological studies consisting in cultures of the epididymal tissues and mid-stream urine specimens, as well as examination of the urethral swabs--before and after prostatic massage--were performed. Labora...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549519
更新日期:1988-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
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更新日期:2018-08-01 00:00:00
abstract::A case of spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder is presented. This morbid state is extremely rare and has not been previously reported to the best of our knowledge. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564762
更新日期:1995-01-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-008-9333-z
更新日期:2008-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1015000328796
更新日期:2001-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9036-2
更新日期:2007-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0046-3
更新日期:2012-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0285-y
更新日期:2013-12-01 00:00:00
abstract::Ureteral endometriosis is a rare disease that typically is unilateral. Endometriosis involving both ureters and surgical management after hormone therapy failure has seldom been described. We describe a patient with bilateral ureteral endometriosis who underwent ureteroneocystostomy with psoas hitches of both ureters....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-0101-7
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1633-8
更新日期:2017-08-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1429-2
更新日期:2017-02-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1038-5
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3621-7
更新日期:2005-01-01 00:00:00