An unexpected presentation: minimal change disease in an adult with treatment-naïve hepatitis C.

Abstract:

:Minimal change disease is the most common glomerular disease affecting children; its prevalence among adults, however, is eclipsed by other glomerular pathologies. Each of these diseases has a number of classic associations, such as membranoproliferative glomerulonephritis with hepatitis C. We report the case of a middle-aged African-American male who presented with the nephrotic syndrome and acute renal failure and was concomitantly diagnosed with a new hepatitis C infection. He also had a history of urethral strictures with potential reflux nephropathy, which--in combination with his African-American race--also made focal segmental glomerulosclerosis a diagnostic possibility. Full laboratory evaluation did not distinguish the cause of his massive proteinuria; subsequent renal biopsy ultimately revealed minimal change disease. A full course of high-dose steroids eventually reduced his proteinuria, after which his renal failure resolved as well without need for hemodialysis.

journal_name

Int Urol Nephrol

authors

Stokes AL,Alhamad T,Abendroth CS,Farag HA,Verma N

doi

10.1007/s11255-012-0285-y

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

1801-4

issue

6

eissn

0301-1623

issn

1573-2584

journal_volume

45

pub_type

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