Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study.

Abstract:

PURPOSE:Cardiovascular calcifications (CVC) are present in up to 70% of non-diabetic dialysis patients. Sparse data are available on predictors of very long-term outcomes of such patients. The Belgrade Aachen Study on Calcification in Hemodialysis patients (BASCH study) aimed to study this using a comprehensive CVC assessment. METHODS:We prospectively analyzed 220 hemodialysis patients followed for a mean of 76 months (median 73 months, range 6-160 months). We compared patients deceased from cardiovascular diseases (CVD) and survivors. Analyses included composite calcification scores (determined by combining ultrasound and X-ray analyses), demographic, clinical and laboratory data and pulse wave velocity (PWV). For survival analysis, patients were divided into group according to quartiles (Q). RESULTS:Compared to survivors, deceased patients from CVD were significantly older, more frequently hypertensive, had shorter dialysis times per week and lower Kt/V values, and they exhibited lower serum fetuin A, osteoprotegerin and hemoglobin as well as higher CRP levels. Composite calcification and Adragao scores were significantly higher in deceased patients from CVD as was PWV. Mean survival was 101 ± 47 months (Q1), 87 ± 51 month (Q2), 66 ± 48 (Q3) and 54 ± 45 months (Q4), p = 0.000. Cox multivariate regression analysis showed that independent predictors for cardiovascular mortality were composite calcification score in the range of third and fourth quartiles. CONCLUSION:Composite calcification score emerged as significant predictors of long-term survival in our group of largely non-diabetic dialysis patient population, finding that should be confirmed by intervention studies.

journal_name

Int Urol Nephrol

authors

Dimkovic N,Schlieper G,Jankovic A,Djuric Z,Ketteler M,Damjanovic T,Djuric P,Marinkovic J,Radojcic Z,Markovic N,Floege J

doi

10.1007/s11255-018-1821-1

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

939-946

issue

5

eissn

0301-1623

issn

1573-2584

pii

10.1007/s11255-018-1821-1

journal_volume

50

pub_type

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