Abstract:
OBJECTIVES:To study the possible renoprotective effect of sildenafil against renal ischemia/reperfusion (I/R) injury and its effect on the expression of some antioxidant, antiapoptotic gene and proinflammatory cytokine genes in rat model of renal I/R injury. MATERIALS AND METHODS:One hundred and twenty male Sprague Dawley rats were subdivided into three equal groups: sham (underwent right nephrectomy without ischemia), control (underwent right nephrectomy and left ischemia for 45 min) and study [as control with 1 mg/kg sildenafil (per oral) 60 min before anesthesia]. Serum creatinine and BUN were measured at the baseline and the study endpoints (2, 24, 48 h and 7 days), and the left kidney was harvested at study endpoints for histopathological examination as well as for assessment of the expression of antioxidant genes (Nrf-2, HO-1 and NQO-1), antiapoptotic gene (Bcl-2) and inflammatory cytokines, e.g., TNF-a, IL-1β and ICAM-1. RESULTS:I/R caused significant increase in serum creatinine, BUN, histopathological damage score (p < 0.001) and significant reduction in antioxidant genes (nrf2, HO-1 and NQO-1) and antiapoptotic gene (Bcl2) with significant increase in TNF-a, IL-1β and ICAM-1 genes in kidney tissues. Pretreatment with sildenafil caused significant attenuation of serum creatinine and BUN as well as significant increase in the expression of antioxidant genes and Bcl-2 genes with significant reduction in the expression of proinflammatory cytokine genes (p value < 0.001). CONCLUSION:The renoprotective effect of sildenafil against renal I/R might be due to the activation of antioxidant genes (Nrf2, HO-1 and NQO-1) and antiapoptotic gene (Bcl2) and attenuation of proinflammatory cytokines (TNF-a, IL-1β and ICAM-1).
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zahran MH,Hussein AM,Barakat N,Awadalla A,Khater S,Harraz A,Shokeir AAdoi
10.1007/s11255-015-1099-5subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1907-15issue
11eissn
0301-1623issn
1573-2584pii
10.1007/s11255-015-1099-5journal_volume
47pub_type
杂志文章abstract::Eighty-four patients with testicular seminoma were treated at the Northern Israel Oncology Center during the years 1968-1988. Using the staging classification of Hussey, 69 patients (82%) had Stage I, eight (10%) had Stage IIA, four (5%) had Stage IIB, one (1%) had Stage IIIA, and two (2%) had Stage IIIB disease. Sixt...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768019
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1633-8
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To correlate the accuracy of intraoperative and surgical specimen (ex vivo) ultrasound (US) with pathological margin status at partial nephrectomy. MATERIALS AND METHODS:Patients undergoing partial nephrectomy for T1 renal tumours in the period May 2010-January 2014 at a single institution who had intraoperati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1083-0
更新日期:2015-10-01 00:00:00
abstract::Two cases of rarely observed granulomatous prostatitis are presented. Unspecific clinical symptoms and a close similarity in clinical course to prostatic adenoma or adenocarcinoma may be misleading and produce severe diagnostic difficulties even for an experienced urologist. Close cooperation with a pathomorphologist ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02084115
更新日期:1986-01-01 00:00:00
abstract::A unilateral adrenal tumour was incidentally detected in a 39-year-old woman with no characteristic features of Cushing's syndrome. Basal levels of glucocorticoids were within normal limits. However, abnormal pattern of plasma cortisol and ACTH was observed. The dexamethasone suppression test and the metyrapone test s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::A rare case of benign pelvic neurilemmoma with bladder infiltration and ureteral obstruction is presented. This neurally originated tumor may occur anywhere in the body, but involvement of the urinary tract is rare. Management depends upon location and other clinical findings, and in this case, since complete removal ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082366
更新日期:1978-01-01 00:00:00
abstract:PURPOSE:Hippocampus plays an important role in spatial learning and memory. Ghrelin, a brain-gut peptide, participates in the mnestic functions of hippocampus through its receptor growth hormone secretagogue receptor (GHS-R) distributed in hippocampus. This study was to investigate whether there was a correlation betwe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1228-9
更新日期:2016-05-01 00:00:00
abstract::This study compares the safety and efficacy of mechanical cystolithotripsy (MCLT) and extracorporeal shock wave lithotripsy (ESWL) in the treatment of vesical stones. In the last four years we have treated 144 bladder lithiasis patients with MCLT (86; group A) and ESWL (58; group B). All patients in group A were treat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768241
更新日期:1994-01-01 00:00:00
abstract::The aim of this study was to investigate the relationship between microvessel density (MVD), positive and negative angiogenic factors, and established prognostic factors in prostate cancer (PC), and, to clarify the effect of angiogenic factors to angiogenesis. The vascularization of neoplastic, non-neoplastic prostate...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9144-z
更新日期:2007-01-01 00:00:00
abstract::The development of a reno-jejunal fistula following a Roux-en-Y cystojejunostomy for an incorrectly diagnosed pancreatic pseudocyst is described. Up to now, this is the second case of iatrogenic reno-jejunal fistula reported in literature. Reno-jejunal fistulas are exceedingly rare and are usually consequences of urol...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007115605427
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:The purpose was to evaluate the efficacy of the addition of short-term desmopressin to enuretic alarm in patients with primary monosymptomatic nocturnal enuresis (PMNE). MATERIALS AND METHODS:A total of 58 [corrected] children with PMNE were included in this study. The patients were randomized into two group...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-008-9355-6
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The impact of radical surgery for urothelial carcinoma is significant on patient's quality of life. Organ-sparing surgery (OSS) can provide comparable oncological outcomes and with improved quality of life. In this review, we summarize the indications, techniques and outcomes of OSS for these tumors. METHODS:P...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-019-02232-z
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:This present study aims to investigate the relationship between laboratory parameters on admission and prognosis of coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, as well as providing a theoretical basis for clinical evaluation of prognosis and corresponding intervention measures. ME...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02646-0
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:HAAKI is a common clinical problem in hospitalized patients. Its incidence is high in older patients and carries worse prognosis. The presence of multiple co-morbidities, aging process, and frequent diagnostic and therapeutic interventions predispose elderly patients to HAAKI. This study aims to evaluate the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02130-4
更新日期:2019-05-01 00:00:00
abstract::The authors report a rare case of imperforate anus as a congenital anomaly. Early diagnosis and close follow up are emphasized, in order to prevent the development of complications which may last for a lifetime. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549605
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:To compare the long-term effects of the interleukin-2 receptor antagonist basiliximab versus rabbit antithymocyte globulin as an induction therapy for living-related renal transplantation. METHODS:This is a prospective, open-label, nonrandomized, controlled study including 213 cases of renal transplant. Immuno...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1307-y
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and will lead some unfavorable outcomes such as end-stage renal disease. The efficacy of tonsillectomy remains controversial in both Asian and Caucasian ethnicity. Our meta-analysis was aiming at exploring its long-term efficacy and providin...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-016-1432-7
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS:A total of 1,367 patients with TC and different subsequent therapeutic procedur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0554-4
更新日期:2014-04-01 00:00:00
abstract::The paper deals with the authors' own experience in endoscopic treatment of urethrostenosis in males. Since 1980, 86 patients have been treated in this manner. Good results were obtained in 60 (70%) after one surgical procedure and in 18 (21%) after two operations. Two patients were operated upon by routine methods. W...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550611
更新日期:1988-01-01 00:00:00
abstract::A case of spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder is presented. This morbid state is extremely rare and has not been previously reported to the best of our knowledge. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564762
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:In this research, the normal anatomy of urethral sphincter complex in young Chinese males has been studied. METHODS:The sagittal, coronal, and axial T2-weighted non-fat suppressed fast spin-echo images of pelvic cavities of 86 Chinese young males were studied. RESULT:Urethral sphincter complex is a cylindrica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0686-1
更新日期:2014-08-01 00:00:00
abstract::We have been using the flexible cystoscope since 1987. Detailed information is given concerning the technique of flexible cystoscopy, its indications, advantages and disadvantages. A comparison is made with the results obtained using the rigid cystoscope in an initial series of 100 patients, yielding false negative re...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549531
更新日期:1992-01-01 00:00:00
abstract::Ganglioneuroblastoma is a common type of tumor in children, but is rarely seen in adults. We present here a case of adrenal ganglioneuroblastoma in a 59-year old man. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0851-z
更新日期:2004-01-01 00:00:00
abstract::The urethral syndrome is generally not associated clinically with urethral changes, however, histology often reveals inflammatory or degenerative alterations. The conventionally diagnosed urethral syndrome can certainly be considered to be a synonym of chronic urethritis in adult females. The remarkable histological l...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082229
更新日期:1979-01-01 00:00:00
abstract::In this study we explored the possible role of arachidonoylethanolamine (AEA) in regulating blood pressure in patients on continuous ambulatory peritoneal dialysis (CAPD). One hundred and five patients on CAPD were enrolled. Volume status was evaluated by the overhydration (OH) value obtained by bioimpedance analysis....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0153-9
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To determine the effectiveness of Vacuum-Assisted Closure Device in the postoperative wound care for Fournier's gangrene METHODS: We performed a systematic review in the following databases: Medline (Ovid), EMBASE, and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02705-6
更新日期:2020-11-13 00:00:00
abstract::It is well known that some antibiotics are particularly nephrotoxic. In the present study we investigated kidney function and AAP excretion (as an index of nephrotoxicity) in patients with urinary tract infection treated with CAZ or CTX plus TOB. The main cause of infection was E. coli in both treated groups. After 10...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550604
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Evaluation of ultrasonographic abnormalities with active Schistosoma haematobium infection in Yemeni patients. METHODS:As part of a cooperation between a private hospital and Schistosomiasis Control Project in Yemen, laboratory and ultrasonographic examinations were performed in 158 patients (8 females, 150 ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007168507070
更新日期:1999-01-01 00:00:00
abstract::Segmental cystectomy or total cystectomy was performed in 26 patients with newly diagnosed stage T1, grade 3 transitional cell carcinoma of the bladder. Their histological specimens were assessed with regard to types of tumour cell spread, small vessel involvement and coexistent carcinoma in situ. Patients were follow...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550418
更新日期:1991-01-01 00:00:00
abstract::Tubular reabsorption of magnesium ( TRMg ) was calculated from the values of plasma ultrafiltrable Mg and urinary Mg in 36 patients with transplanted kidneys. The study revealed a defect in TRMg in all investigated patients. The lowest TRMg values were found in patients with poor function of the transplanted kidneys. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082706
更新日期:1984-01-01 00:00:00