Abstract：
PURPOSE:Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear. METHODS:The subjects comprised 567 men aged 71 ± 8 (mean ± standard deviation) years and 853 women aged 70 ± 8 years from a rural village. We examined the relationship between SUA and T-BiL, and renal function was evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation. RESULTS:Stepwise multiple regression analysis using eGFR as an objective variable, adjusted for risk factors as explanatory variables, showed that SUA (β = -0.358, p < 0.001) as well as age (β = -0.534, p < 0.001), drinking status (β = 0.119, p < 0.001), and the presence of antihypertensive medication (β = -0.058, p = 0.005) were significantly and independently associated with eGFR, but T-BiL was not associated with eGFR. While in the group with the highest tertile of SUA, T-BiL (β = 0.081, p = 0.032) was significantly and independently associated with eGFR, and in the group with the lowest to middle tertile of SUA, T-BiL was not associated with eGFR. In addition, interaction between SUA and T-BiL (F = 8.512, p = 0.004) as well as age, drinking status, the presence of antihypertensive medication, SUA, and T-BiL was a significant and independent determinant for eGFR. CONCLUSIONS:Our data demonstrated that low T-BiL could be important as a potential risk factor for renal dysfunction in those with high SUA.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Kawamoto R,Ninomiya D,Senzaki K,Kasai Y,Kusunoki T,Ohtsuka N,Kumagi Tdoi
10.1007/s11255-017-1633-8subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1439-1446issue
8eissn
0301-1623issn
1573-2584pii
10.1007/s11255-017-1633-8journal_volume
49pub_type
杂志文章abstract：BACKGROUND:In the last decade, despite constant investigation, no current single treatment has been able to decrease the incidence of diabetic nephropathy and to significantly reduce progression of diabetic CKD. METHODS:Patients with type 2 diabetes mellitus and proteinuria (>0.5 g/day) after a screening and treatment...
journal_title：International urology and nephrology
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abstract：:The effects of haemodialysate and its three peptide fractions on acetylcholinesterase (AChE, E.C. 3.1.1.7) activity in erythrocytes from healthy subjects and patients with terminal renal insufficiency treated by repeated haemodialyses have been studied. It was shown that erythrocytes from haemodialysed patients displa...
journal_title：International urology and nephrology
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abstract：PURPOSE:This study examined whether the laser-capture microdissection (LCM) method can achieve separation of urothelial cells from detrusor cells or superficial urothelial cells from intermediate/basal urothelial cells, using α-smooth muscle actin (SMA) and cytokeratin 20 (CK20). In addition, we investigated the change...
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abstract：:This study evaluated the incidence of rectal bleeding in patients with prostatic carcinoma treated with three-dimensional conformal radiotherapy (3D-CRT). A total of 32 patients received mean 68.87 Gy 3D-CRT, the mean follow up time was 23.68 months. There was not statistically significant difference between the group...
journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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