Population standards of prostate specific antigen values in men over 40: community based study in Turkey.

Abstract:

OBJECTIVE:To determine the prostate specific antigen (PSA) population standards of a cluster of Turkish men with no clinical evidence of prostate cancer. PATIENTS AND METHODS:We evaluated PSA values of the men who were living in a well-defined, rural district of Western Anatolia. Two hundred fifty-seven men agreed to participate in this population-based study. They underwent clinical examination, transrectal ultrasonography and serum PSA measurement. The association between serum PSA and age, prostate volume and age, PSA and prostate volume, and PSA density (PSAD) and age were assessed. Distributions of serum PSA levels, prostate volumes (PV), and PSAD values as a function of age were generated. RESULTS:The upper limit of normal PSA concentration were 4.51 ng/ml for men aged 40-49 years, 4.36 ng/ml for 50-59 years, 6.17 ng/ml for 60-69 years, and 10.18 ng/ml for over 70 years. The upper limit of normal (95th percentile) for the serum PSA concentration increased with age. Across the entire age range, no correlation was found between the serum PSA concentrations and age while significant correlation was found between serum PSA concentration and prostate volume. CONCLUSION:In this present study, the PSA values in different age intervals showed higher than those observed in previous studies. The PSA values are mainly affected by prostate volume rather than age.

journal_name

Int Urol Nephrol

authors

Müezzinoğlu T,Lekili M,Eser E,Uyanik BS,Büyüksu C

doi

10.1007/s11255-004-7976-y

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

299-304

issue

2

eissn

0301-1623

issn

1573-2584

journal_volume

37

pub_type

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