Abstract:
INTRODUCTION:Impaired kidney function is common in kidney-transplanted patients and complications of chronic kidney disease (CKD), such as mineral and bone disorders (MBD) are also prevalent in this population. Similarly to other stages of CKD, increasing evidence supports the association between MBD and cardiovascular risk after kidney transplantation as well. Still, little is known about the prevalence, clinical correlates of MBD and its management in transplanted patients. In this study, we aimed to examine the characteristics of MBD and its associations with clinical parameters in a large prevalent cohort of patients after kidney transplantation. METHODS:Nine hundred and ninety stable patients followed at a single kidney transplant outpatient clinic were included in the study. Detailed medical history, demographic data and routine laboratory results, including Ca, P and intact PTH were collected. Estimated GFR was calculated using the abbreviated MDRD formula, patients were stratified into three groups based on eGFR. Target levels for Ca, P and iPTH were based on CKD stages according to the NKF-K/DOQI guidelines. Standard statistical procedures, binomial and multinomial regressions were used in the analysis. RESULTS:The mean age was 51 years, 57% were males and 21% were diabetic, with 72 months (median) post-transplantation. Most of the patients were in CKD stage 3. Serum phosphorus showed strong negative correlation with graft function in CKD stages 4-5 (r = -0.633, P < 0.001). Hyperphosphatemia was independently associated with the time spent on dialysis before transplantation, serum iPTH and CKD stages 4-5. iPTH showed negative correlation with eGFR in CKD stages 3-5 (rho = -0.289, P < 0.001) and weak positive correlation with time spent on dialysis prior to transplant (rho = 0.114, P < 0.001). Both hyperparathyroidism (42%) and relative hypoparathyroidism (15%) were frequent. The prescription of P-binders (6%) and vitamin D analogs (33%) was sporadic. CONCLUSION:Disturbances of bone and mineral metabolism after transplantation are prevalent and are strongly correlated with the kidney function, similarly to non-transplanted CKD patients. MBD in this population is not adequately managed.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Ambrus C,Molnar MZ,Czira ME,Rosivall L,Kiss I,Remport A,Szathmari M,Mucsi Idoi
10.1007/s11255-009-9631-0subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1029-38issue
4eissn
0301-1623issn
1573-2584journal_volume
41pub_type
杂志文章abstract:OBJECTIVE:We aimed to describe our experience in administering an innovative surgical technique to treat pediatric cases of exstrophy-epispadias complex. MATERIAL AND METHODS:Between 1995 and 2004, seven consecutive patients (six males) with exstrophy-epispadias complex were treated using ileocecal segment for bladder...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9143-0
更新日期:2007-01-01 00:00:00
abstract::Two groups of 50 consecutive patients each, with distal ureteric calculi, were treated by ureteroscopy or in situ ESWL (Dornier HM-4 lithotriptor) in order to establish the effectiveness of ESWL at the distal portion of the ureter. In comparison to ureteroscopy, ESWL for distal ureteral calculi was performed on an out...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552156
更新日期:1996-01-01 00:00:00
abstract::Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocel...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1839-4
更新日期:2018-04-01 00:00:00
abstract::Cyclophosphamide was introduced in 1958 in an effort to minimize the side effects of nitrogen mustard. Cyclophosphamide (Cytoxan, Endoxan) is not an alkylating agent which has been used for the treatment of a variety of non-malignant as well as malignant diseases. It has also recently been the focus of considerable in...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082484
更新日期:1985-01-01 00:00:00
abstract:PURPOSE:Reusable flexible-ureteroscopes (fURS) require personnel and budget for processing and repairing, whereas single-use fURS were recently developed. After exclusive reusable fURS since 2011, we experienced high repair costs and single-use fURS were therefore introduced in mid-2017. We aimed to evaluate economic a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02230-1
更新日期:2019-10-01 00:00:00
abstract::A case of spontaneous right uretero-cutaneous fistula complicated by spontaneous rupture of the urinary bladder is presented. This morbid state is extremely rare and has not been previously reported to the best of our knowledge. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564762
更新日期:1995-01-01 00:00:00
abstract::We report on our experience with a new surgical procedure of forming a pseudoneotesticle from indigenous tissues obtained from the existing scrotal contents. This procedure has been performed in 32 patients with a diagnosis of hormone dependent cancer of the prostate as a therapeutic manoeuvre, and in 3 children who h...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550317
更新日期:1998-01-01 00:00:00
abstract::Renal inflammatory pseudotumor is a very rare benign condition of unknown etiology characterized by proliferative myofibroblasts, fibroblasts, histiocytes, and plasma cells. We report a case of inflammatory pseudotumor of the kidney. A 42-year-old female was admitted with the complaint of right flank pain. Computerize...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034661.52215.a3
更新日期:2004-01-01 00:00:00
abstract::Non-refluxing non-obstructive megaureter is a rare condition, usually diagnosed in asymptomatic neonates. We present the case of a 39-year-old male, who presented with a 6-month history of recurrent UTIs and intermittent frank haematuria. IVU, flexible cystoscopy and micturating cystogram confirmed characteristically ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9054-0
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:Metformin has been shown to reduce diabetic complications in overweight patients, and is increasingly used to treat this condition. However, this agent is associated with a rare but serious risk of lactic acidosis. METHODS:From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9549-6
更新日期:2009-12-01 00:00:00
abstract::Different methods are available in the diagnosis and treatment of urethral strictures. True diagnosis is necessary for choosing the most suitable method of treatment and to inform the patient about the method, complications, recurrence rate and costs. In this study we aimed to compare the efficiency, complications and...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550731
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the treatment alternatives of total avulsion of the ureter from both ends including ureteropelvic junction (UPJ) and ureterovesical junction (UVJ). METHODS:Total ureteral avulsion on both ends of the ureter was examined in 4 cases performing ureteroscopy. In two male patients of the four cases, ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0505-0
更新日期:2013-12-01 00:00:00
abstract::Bilateral vasovasostomies were performed in 7 previously vasectomized patients. The method employed was a modification of a one-layer anastomotic technique. There was no correlation between the presence of absence of sperm in the vas fluid, presence or absence of sperm granuloma, and site of vasectomy. No correlation ...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02550083
更新日期:1995-01-01 00:00:00
abstract::We present clinical and radiological findings in a case of collecting (Bellini) duct carcinoma (CDC). This is a rare and aggressive kidney cancer originating from the distal renal tubule. The patient underwent radical nephrectomy and the pathological report showed trabeculopapillary, partially solid adenocarcinoma inf...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007148219308
更新日期:1999-01-01 00:00:00
abstract::Patients with metastatic prostate cancer respond to androgen withdrawal therapy, but progression to androgen independence is frequently observed. To clarify the predictor of response to endocrine therapy, the role of PSA changes and the prognosis of the patients were evaluated in 115 Japanese cases of prostate cancer ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014410026495
更新日期:2001-01-01 00:00:00
abstract::A 75-year old man with long-term arterial hypertension was diagnosed in 1998 with stage 3 chronic kidney disease due to hypertensive nephropathy. Since May 2004 the patient has been treated with intermittent hemodialysis. Since 1998 he has been hospitalized several times because of palpitations in the course of paroxy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9302-y
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Detection of circulating tumor cells (CTCs) in cancer patients has diagnostic and prognostic importance. However, the clinical implications of CTC detection in patients with renal cell carcinoma (RCC) are still unclear. In this study, we investigated the clinical significance of CTCs using two detection...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1954-2
更新日期:2018-10-01 00:00:00
abstract::Analysis was performed on the clinical features of children with VUR who had one or two kidneys that were at least -2 SD smaller than normal for age of its renal ratio. The prevalence of the small kidney was 15.6% (97/623 children). Of 107 small kidneys, 87 (82%) were associated with moderate (grade IV) to severe (gra...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549509
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:The venous thromboembolic events (VTE) incidence is high in nephrotic syndrome (NS). We aimed to assess prospectively the risk of VTE in a large cohort of NS patients and to identify predictive factors for VTE, especially haemostasis-related parameters. METHODS:This is the prospective, observational study cond...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0574-0
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:PlasmaKinetic electrode, holmium laser, green laser and Nd: YAG laser have been used for treating benign prostate hyperplasia (BPH). To compare the pathological changes of thermal injury by these different devices. MATERIAL AND METHODS:Tissues donated by several male patients with prostate cancer who have wr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02723-4
更新日期:2021-01-22 00:00:00
abstract::Açai (Euterpe oleracea Mart.) fruit from the Amazon region in Brazil contains bioactive compounds such as α-tocopherol, anthocyanins (cyanidin 3-glycoside and cyanidin 3-rutinoside), and other flavonoids with antioxidant and anti-inflammatory properties. Moreover, the prebiotic activity of anthocyanins in modulating t...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1912-z
更新日期:2018-12-01 00:00:00
abstract::The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Comorbidity has a significant impact on the health status and treatment outcome of a patient. The Charlson comorbidity index (CCI) is a frequently used scoring system, which evaluates the prognosis based on the patient's comorbid conditions. The aim of this study was to evaluate the usefulness of CCI in predict...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02499-7
更新日期:2020-09-01 00:00:00
abstract::Protein Z (PZ) is a vitamin K-dependent protein isolated from human and bovine plasmas. Although the exact role of PZ in the haemostatic system is presently unknown, it is suggested that PZ deficiency may cause bleeding tendency. Haemostatic alterations in end-stage renal failure (ESRF) are certainly complex and invol...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007179631603
更新日期:1999-01-01 00:00:00
abstract:AIMS:Erectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED. METHODS:We designed a strate...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-017-1644-5
更新日期:2017-10-01 00:00:00
abstract::We report a case of penile incarceration in a 53-year-old impotent man. The base of the penis was encircled by a metal ring in order to achieve better erection. There was marked oedema of the entire penis distal to the constricting ring. The metal ring was removed successfully by cutting it with a steel saw. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564752
更新日期:1995-01-01 00:00:00
abstract::In 68 men with benign prostatic hyperplasia, we evaluated the association between obesity and prostatic enlargement, as well as changes in serum levels of oestradiol, testosterone, dihydroepiandrosterone and dihydroepiandrosterone sulphate. Despite the larger adenomas, no increase in the symptom score for BPH was obse...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550138
更新日期:1996-01-01 00:00:00
abstract::Orthostatic hypotension is very common in the elderly. It increases morbidity and is an independant predictor of all cause mortality. It is defined as a fall in systolic blood pressure greater than 20 mm Hg or a fall in diastolic blood pressure greater than 10 mm Hg within 3 minutes of standing. Symptoms include light...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-7663-7
更新日期:2005-01-01 00:00:00
abstract::To compare the anti-inflammatory effectiveness of corticotherapy and nonsteroid anti-inflammatory drugs (NSAID), we examined 126 infertile men with infectious aetiology. Seventy-seven patients were on corticotherapy and antibiotherapy (thirty-eight patients on high-dose and thirty-nine patients on low-dose corticother...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007184125900
更新日期:1999-01-01 00:00:00
abstract::Semen analysis and immunofluorescent antisperm antibodies were tested in 65 patients with varicocele. The mean sperm count and motility values in our study were 36.8 +/- 2.9 million per ml and 38.4 +/- 2.5 per cent, respectively. Both parameters were found not to differ significantly in three grades of varicocele. Imm...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02089408
更新日期:1985-01-01 00:00:00