Abstract:
:Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocele men less fertile. In particular, sperm DNA fragmentation is usually elevated in men with clinical varicocele in both abnormal and normal semen parameters by the current World Health Organization criteria. In this review, we discuss the evidence concerning the association between varicocele, oxidative stress, and SDF, and the possible mechanisms involved in infertility. Furthermore, we summarize the role of varicocele repair as a means of alleviating SDF and improving fertility. Lastly, we critically appraise the evidence-based algorithm recently issued by the Society for Translational Medicine aimed at guiding urologists on the use of SDF testing in men with varicocele seeking fertility. Current evidence based on careful review of published studies confirms the effectiveness of varicocelectomy as a means of both reducing oxidatively induced sperm DNA damage and potentially improving fertility. Varicocele repair should be offered as part of treatment option for male partners of infertile couples presenting with palpable varicoceles.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Roque M,Esteves SCdoi
10.1007/s11255-018-1839-4subject
Has Abstractpub_date
2018-04-01 00:00:00pages
583-603issue
4eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-1839-4journal_volume
50pub_type
杂志文章,评审abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatmen...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-0932-1
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is an adverse consequence of contrast media use that results in significant morbidity and mortality and adds significant costs to diagnostic and interventional cardiology procedures. Various pathophysiological mechanisms have been proposed for CIN and various agents have be...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-011-0053-4
更新日期:2012-08-01 00:00:00
abstract::Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently results in end-stage renal disease (ESRD). Different pathophysiologic mechanisms have been proposed to explain the development o...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1803-3
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To correlate the accuracy of intraoperative and surgical specimen (ex vivo) ultrasound (US) with pathological margin status at partial nephrectomy. MATERIALS AND METHODS:Patients undergoing partial nephrectomy for T1 renal tumours in the period May 2010-January 2014 at a single institution who had intraoperati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1083-0
更新日期:2015-10-01 00:00:00
abstract::The authors present four cases of operatively confirmed anorchism. The plasma levels of testosterone and 11-deoxy-17-ketosteroids and dehydroisoandrosterone in urine were low in all cases. After stimulation with HCG, plasma testosterone levels increased in two cases and did not change in another two. The levels of 11-...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082812
更新日期:1979-01-01 00:00:00
abstract::Twenty patients on home peritoneal dialysis were studied during two years. The patients dialysed 4--5 times a week, using an average of 78 l dialysis fluid. The dialysis equipment used was either a simplified delivery system or a fully automatic dialysis machine. Despite clinical improvement, serum urea and serum crea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081965
更新日期:1979-01-01 00:00:00
abstract::Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to ur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9434-8
更新日期:2009-01-01 00:00:00
abstract::Five cases of spontaneous rupture of the renal parenchyma are reported. Two patients had renal cell cancer, one sustained acute purulent pyelonephritis secondary to stone related ureteral obstruction, one suffered from aposthematous pyelonephritis without obstruction, while one had chronic pyelonephritis and a cortica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768275
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Previous studies on the association between extracorporeal shock wave lithotripsy (SWL) and new onset hypertension have only illustrated contradictory results. In order to illustrate the association between SWL and new onset hypertension, a meta-analysis of case-control and cohort studies was conducted. METH...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-013-0588-7
更新日期:2014-04-01 00:00:00
abstract::Idiopathic Localised Bladder Amyloidosis is a rare cause of haematuria and urinary tract symptoms. A review of the literature highlights the varied presentations and the appropriate investigations for this condition, with emphasise on the exclusion of a secondary cause. In addition, the range of treatment options is f...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1021302827755
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE/BACKGROUND:The aim of this study was to evaluate the efficacy of the autologous fascia rectus sling in treating stress urinary incontinence in female patients with neuropathic bladder. Furthermore, correlations between preoperative parameters and outcome were evaluated. METHODS AND DESIGN:We retrospectively ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0247-4
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the treatment alternatives of total avulsion of the ureter from both ends including ureteropelvic junction (UPJ) and ureterovesical junction (UVJ). METHODS:Total ureteral avulsion on both ends of the ureter was examined in 4 cases performing ureteroscopy. In two male patients of the four cases, ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-013-0505-0
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3621-7
更新日期:2005-01-01 00:00:00
abstract::Posterior urethral valves are usually detected during infancy by prenatal sonography. Less is known about presentation and outcome in older patients. We are describing a patient who presented with renal stones and was found incidentally on cystoscopy to have Type I urethral valves. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020294.84579.a4
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6657-4
更新日期:2006-01-01 00:00:00
abstract::The first time in Scandinavia we present a case report of a pure primary low-grade neuroendocrine carcinoma (carcinoid tumor) of the prostate. Our patient is a 34-year-old male with a long history of symptomatic chronic prostatitis/prostatodynia. After developing severe obstructive uropathy, a transurethral resection ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9660-8
更新日期:2010-09-01 00:00:00
abstract::Fibrosing cholestatic hepatitis (FCH) is an uncommon complication of renal transplantation. It is usually associated with hepatitis B and C viral infection. It is further rare in renal transplantation in absence of HBV and HCV infection. To the best of our knowledge, only three cases of FCH in renal transplantation, w...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-004-6196-9
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To investigate whether the treatment of overt postpartum urinary retention (PUR) with low-intensity pulsed ultrasound (LIPUS) was clinically effective and whether LIPUS could accelerate bladder smooth muscle (BSM) contraction by opening the L-type calcium channels and activating the Ca(2+) signaling pathway. M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1298-8
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. METHODS:Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention g...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02423-z
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:The age-related decline of the testosterone-to-estrogen (T-to-E2) ratio in serum is associated with the increased prevalence of prostatic inflammation. The goal of the study was to induce prostatic inflammation with E2 and androgen treatment and to explore the inflammatory markers and apoptosis on prostatitis. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0845-4
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Some studies have found that prostate cancer (PCa) screening provides little or no change in PCa-related mortality during the 7-10 years following diagnoses. However, most men are diagnosed with PCa at low-stage disease and die of unrelated causes during this period. Men diagnosed at stage IV are at much high...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9799-3
更新日期:2011-06-01 00:00:00
abstract::Renal blood flow measurements have been carried out by means of positron emission tomography (PET) to facilitate the detection of radiation-induced injuries. The advantages of the method employed in animal experiments are described. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550121
更新日期:1992-01-01 00:00:00
abstract::Two groups of 50 consecutive patients each, with distal ureteric calculi, were treated by ureteroscopy or in situ ESWL (Dornier HM-4 lithotriptor) in order to establish the effectiveness of ESWL at the distal portion of the ureter. In comparison to ureteroscopy, ESWL for distal ureteral calculi was performed on an out...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02552156
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To perform a systematic review and meta-analysis to evaluate the cardiovascular prevention effect of aspirin among patients with chronic kidney disease (CKD). METHODS:A comprehensive literature search was conducted in Embase, PubMed, and Cochrane library (up to March 2019) without language limitations. Randomi...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析
doi:10.1007/s11255-019-02350-8
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:Chronic hepatitis B virus (HBV) carrier status has a critical impact on clinical management of patients with IgA nephropathy (IgAN) who are treated with corticosteroids, because corticosteroids may enhance HBV replication. This study compared corticosteroids and antivirals combined therapy with corticosteroid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0480-5
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS:The goal of this study was to investigate the effect of a combinatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1478-6
更新日期:2017-03-01 00:00:00
abstract::In our center between 1992 and 1994 penile Mondor's disease (superficial dorsal penile vein thrombosis) was diagnosed in 5 patients aged 20-39 years. In all patients the thromboses were noted 24-48 hours after a prolonged sexual act with or without an intercourse. the main symptom was a cord-like thickening of the sup...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550502
更新日期:1996-01-01 00:00:00
abstract::The authors describe an uncommon case of a huge perinephric abscess with a gas-fluid level occupying the upper left abdomen. A rational sequence of radiological diagnostic methods such as plain film, ultrasound, CT, and combined retrograde urogram with contrast filling of percutaneous drainage led to correct managemen...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549707
更新日期:1991-01-01 00:00:00
abstract::Endometriosis of the urinary tract is a relatively rare condition. Since clinical signs are not specific the diagnosis is difficult and the therapy is not well defined. Two cases and a review of the literature are presented. ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/BF02551109
更新日期:1997-01-01 00:00:00