Abstract:
:Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to urinary loss of this protein. We report the case of a 7-year-old girl with relapse of nephrotic syndrome and with a clinical risk for thromboembolic complications, identified by very low AT III and albumin serum levels and high fibrinogen and cholesterol serum levels. However, having symptoms of hypovolemia, she was treated with albumin and diuretics, known risk factors for thrombotic incidents, although these drugs were both administered after prophylactic intravenous antithrombin. There are no randomized controlled clinical trials supporting prophylactic anticoagulation in the management of nephrotic syndrome. Arterial thromboses during nephrotic syndrome has been associated with thrombophilic states and the use of diuretics. It might be advisable to do laboratory monitoring for coagulation profiling and, in children at risk, prophylactic treatment with AT III before administering albumin infusion and diuretics.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zaffanello M,Brugnara M,Fanos V,Franchini Mdoi
10.1007/s11255-008-9434-8subject
Has Abstractpub_date
2009-01-01 00:00:00pages
713-6issue
3eissn
0301-1623issn
1573-2584journal_volume
41pub_type
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journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
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journal_title:International urology and nephrology
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pub_type: 杂志文章
doi:10.1007/s11255-019-02216-z
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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