Abstract:
PURPOSE:To compare the therapeutic effects and adverse events (AE) of current first-line treatments of advanced RCC, including sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab and IFN-α. METHODS:We performed a meta-analysis of randomized controlled trials of the effectiveness of the five treatments among patients with advanced RCC. The data of progressive disease, objective response rate (ORR), disease control rate (DCR), grade 3/4 AE, progression-free survival (PFS), and overall survival (OS) were extracted to assess therapeutic effects, toxicity, and prognosis, respectively. RESULTS:Two studies that assessed the combination of bevacizumab with IFN α (n = 1381), one sunitinib (n = 750), one sorafenib (n = 189) and one temsirolimus (n = 416) were included. Sorafenib, sunitinib, temsirolimus (R = 0.35, 95% confidence interval [CI] 0.26-0.48, P < 0.01), and the combination of bevacizumab with IFN (R = 0.64, 95% CI 0.42-0.99, P = 0.04) were more effective in controlling tumor progression than IFN. Sorafenib, sunitinib, and temsirolimus do not own advantage in ORR compared with IFN (R = 2.06, 95% CI 0.53-7.95, P = 0.30), but combination of bevacizumab with IFN showed better results in ORR than IFN (R = 2.56, 95% CI 1.91-3.42, P < 0.01). Sorafenib, sunitinib, temsirolimus (R = 2.90, 95% CI 2.23-3.78, P < 0.01), and combination of bevacizumab with IFN (R = 2.14, 95% CI 1.65-2.78, P < 0.01) were more effective than IFN in DCR. Sorafenib, sunitinib, and temsirolimus had similar rate of grade 3/4 AE as IFN (R = 1.21, 95% CI 0.96-1.51, P = 0.10). Combined use of bevacizumab and IFN is associated with higher frequency of the AE (R = 2.09, 95% CI 1.66-2.63, P < 0.01). Sorafenib and sunitinib had similar median PFS (R = 0.67, 95% CI 0.42-1.08, P = 0.10); temsirolimus had longer median OS (R = 0.82, 95% CI 0.67-1.00, P = 0.049) as IFN. Combined use of bevacizumab and IFN had longer median PFS (R = 0.68, 95% CI 0.60-0.76, P < 0.01) and OS (R = 0.86, 95% CI 0.76-0.97, P = 0.01) than IFN. CONCLUSION:Sorafenib, sunitinib, temsirolimus, and the combination of bevacizumab with IFN are more effective in stabilizing disease. Combined use of bevacizumab and IFN is better than sorafenib, sunitinib, and temsirolimus in ORR, PFS, and OS, but associated with higher level of AE.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Wang L,Ma L,Wang X,Li B,Guo S,Qiao Qdoi
10.1007/s11255-015-0932-1subject
Has Abstractpub_date
2015-04-01 00:00:00pages
617-24issue
4eissn
0301-1623issn
1573-2584journal_volume
47pub_type
杂志文章,meta分析,评审abstract::We report a case of 20-year-old farmer with penile amputation and emasculation secondary to crushing injury inflicted by agricultural machinery. His entire penis, scrotum and both the testis had been avulsed after falling onto a rotating axel wheel of an electronically driven thrashing machine. After resuscitation the...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0918-x
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:This study aimed to evaluate the association among the expressions of pro- and anti-inflammatory nuclear factors (nuclear factor-kappaB, NF-κB and nuclear erythroid 2-related factor 2, Nrf2) and nutritional status in HD patients. METHODS:This cross-sectional study included eighty-three HD patients. The periphe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1425-6
更新日期:2016-12-01 00:00:00
abstract::The recommended treatment for patients with severe bleeding from upper gastrointestinal (GI) metastases is embolisation. We report a case in which despite adequate embolisation major haemorrhage from renal cell carcinoma (RCC) gastric metastases continually recurred. During a severe bleed refractory to embolisation oc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-0251-z
更新日期:2005-01-01 00:00:00
abstract:AIM:Chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS) is a common disabling condition that is primarily associated with pain in the urogenital region and disturbances in urinary and sexual function. Chronic pelvic pain symptoms are the most common presentation, especially perineal, lower abdominal, testi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9809-5
更新日期:2011-06-01 00:00:00
abstract::The aim of this study was to find out whether an improvement of vitamin D metabolism and its metabolites and a decrease of parathormones can be reached through a diet and UV irradiation. Forty-eight children with kidney insufficiency were divided into four groups: Group 1--diet according to Bergström with EAA and ceto...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Ureteric stents, a good solution to many urologic problems, can lead to significant morbidity if left in situ longer than required. Our case is that of an elderly male with a history of intractable hypertension presenting with urosepsis, anemia, diabetes and chronic renal failure. His work-up revealed a stent in the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0021-3
更新日期:2005-01-01 00:00:00
abstract::Deoxyribonuclease (DNase) activity and metal ion concentrations in lymphocytes of patients with chronic renal failure and in healthy controls were studied. The data suggest that T and B lymphocyte nuclei of patients with renal failure show increased DNase activity when compared to their healthy counterparts. It is sug...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552124
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:Residual diuresis progressively decreases with longer dialysis vintage, and higher incidence of renal and urinary tract cancers was often observed in hemodialyzed patients compared to the general population so we hypothesized that patients without preserved residual diuresis have higher risk of renal and urinar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1723-7
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The numbers of older people on haemodialysis is rising. As aging and renal failure are risk factors for autonomic failure and haemodialysis involves significant fluid shifts we hypothesized that older patients would be susceptible to hypotensive events between dialysis sessions. Postural hypotension is a ris...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000022866.07751.4a
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1755-z
更新日期:2018-02-01 00:00:00
abstract::Renal arterial embolization and subsequent nephrectomy or nephrectomy alone were performed in 34 patients with renal cell carcinoma. Renal arterial embolization caused a blood pressure elevation concomitant with an increase in plasma renin activity (PRA), urinary aldosterone excretion or urinary prostaglandin (PGE2) e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549489
更新日期:1988-01-01 00:00:00
abstract::We present the case of a 31-year-old spina bifida patient presenting with a poorly differentiated T3N1M0 bladder carcinoma with sarcomatoid differentiation in an auto-augmented bladder. She underwent a radical cystectomy and a bilateral lymph node dissection. However, only 10 months after the onset of her symptoms, sh...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-0046-3
更新日期:2012-08-01 00:00:00
abstract::Primary squamous cell carcinoma of seminal vesicle is extremely rare, and most cases regarding seminal vesicle tumors failed to address this kind of tumor. A 54-year-old male patient presented with intermittent painless visual hematuria for 6 months was hospitalized. Ultrasonography, computerized tomography and magnet...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0373-z
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Early detection of prostate cancer has become a matter of vital importance in modern societies. Ultrasound guided transrectal biopsy is the current standard urological procedure to detect prostate cancer. In this study our intention was to confirm the high tolerance and low complication rate of this procedure...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007168823851
更新日期:1999-01-01 00:00:00
abstract::Crossed renal ectopia and/or asymmetric fused kidney are unusual congenital anomalies. The deformity itself usually produces no symptoms and the clinical presentation generally suggests obstruction and infection. In our series, 10 of 11 patients presented with various vertebral anomalies. A theory of embryogenesis was...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549675
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of α-lipoic acid (α-LA) in the prevention and treatment of ethylene glycol-induced calcium oxalate deposition in a rat model and preliminary exploration of the mechanism. METHODS:Sixty male Wistar rats were divided randomly and equally into six groups including two α-LA prevention g...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02423-z
更新日期:2020-07-01 00:00:00
abstract::Sirolimus is an immunosupressor of the mammalian target of rapamycin inhibitors (mTOR-I) group. Recent studies have emphasized a potential impact of sirolimus on male gonadal function. We report our clinical experience with sirolimus-induced gonadal dysfunction and infertility in both male and female kidney transplant...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9644-8
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:Progression of the cell cycle is regulated by the interactions of cyclins, cyclin dependent kinases (CDKs) and CDK inhibitors (CDKIs). p27 is a member of the universal cyclin-dependent kinase inhibitor family. The level of p27 protein expression decreases during tumor development and progression in some epit...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000020301.39181.03
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The use of interactive voting systems in continuing education helps to evaluate the alteration in the audience's views after a presentation. This study was designed to evaluate whether urologists' attitude towards management of benign prostate hyperplasia can be changed, and to estimate objectively the achievem...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9183-0
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Limited numbers of literatures have focused on the association between γ-glutamyltransferase (GGT) and chronic kidney disease (CKD), and their results were controversial. Therefore, in this study, we set up a large-scale cohort of Chinese population to discover and verify the association between serum GGT and C...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1429-2
更新日期:2017-02-01 00:00:00
abstract:PURPOSE:Pulmonary embolism with viable tumor cells developed after surgery for renal cell carcinoma may metastasize to lung. We investigated the incidence and fate of newly developed pulmonary embolism after surgery for renal cell carcinoma with vena cava thrombus. METHODS:Among 4549 renal cell carcinoma patients trea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1583-1
更新日期:2017-07-01 00:00:00
abstract:PURPOSE:To evaluate the results of plaque incision and venous patch grafting to correct the dorsal curvature associated with Peyronie's disease. MATERIALS AND METHODS:18 patients with Peyronie's disease were treated surgically. All of the patients have dorsal penile curvature for more than one year causing intromissio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1023290705439
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine the morbidity of lumbotomy incision used in the last 100 living related donor nephrectomies retrospectively. METHODS:Since March 1991, 100 donor nephrectomies were made to living donors with lumbar incision. Incisions made in lateral decubitus position, subcostally o...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1015000328796
更新日期:2001-01-01 00:00:00
abstract::The aim of this study was to investigate the hormonal and hemodynamic changes during percutaneous nephrolithotomy (PCNL) procedure. Twenty-one patients between 15-65 years of age were included in the study. Invasive blood pressure and heart rate were monitored during PCNL. Serum sodium, potassium, BUN and creatinine l...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017527126481
更新日期:2001-01-01 00:00:00
abstract::We describe and report two cases of bilateral symptomatic ureterocele with calculi in two young adult women. They were successfully managed endoscopically by a transverse meatotomy and stone extraction done bilaterally in a single operative session. The 6th month postoperative voiding cystourethrogram showed no reflux...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-006-0091-5
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-018-1814-0
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. METHODS:SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-rea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0233-x
更新日期:2013-08-01 00:00:00
abstract:PURPOSE:To evaluate the usage of unidirectional barbed suture and its related implications in various surgeon-controlled robotic reconstructive urologic surgeries. METHODS:From March 2010 to March 2011, all patients undergoing various surgeon-controlled robotic reconstructive urologic surgeries utilizing barbed suture...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-011-0075-y
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) secondary to acute tubular necrosis (ATN) is common in critically ill patients, and causes significant morbidity and mortality. The underlying etiology of ATN can be divided into pure ischemic, pure nephrotoxic, and mixed causes. This post-hoc analysis of a prospective cohort study ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9994-x
更新日期:2012-12-01 00:00:00
abstract::The vaginal influx during miction is a frequent phenomenon. In our clinical study it showed a rate of 54 per cent. The significance of pathomorphological substrates is diminishing with the advancing vesical descensus. The posture during miction has but little influence on the vaginal deviation of the urinary stream. T...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02086819
更新日期:1979-01-01 00:00:00