Abstract：
PURPOSE:This study aimed to evaluate the association among the expressions of pro- and anti-inflammatory nuclear factors (nuclear factor-kappaB, NF-κB and nuclear erythroid 2-related factor 2, Nrf2) and nutritional status in HD patients. METHODS:This cross-sectional study included eighty-three HD patients. The peripheral blood mononuclear cells were isolated and processed for the evaluation of NF-κB and Nrf2 RNAm expression by quantitative real-time polymerase chain reaction. Muscle mass was estimated by creatinine index (CI) and percentage of body fat (%BF) by anthropometry. Seven-point subjective global assessment was also used to evaluate the nutritional status. RESULTS:The NF-κB expression was negatively correlated with CI (r = -0.54, p = 0.0001), serum albumin (r = -0.32, p = 0.02) and %BF (r = -0.61, p = 0.001). Multiple linear regression analysis revealed that NF-κB expression was independently associated with CI (β: -0.8, p = 0.013) and %BF (β: -0.42, p = 0.04). There was no correlation among Nrf2 and anthropometric and biochemical variables. CONCLUSION:The classical NF-κB activation seems to be associated with poor nutritional status in HD patients; however, the exact underlying mechanisms deserve further studies.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Farage NE,Stockler-Pinto MB,Leal VO,Cardozo LL,Carraro-Eduardo JC,Fouque D,Mafra Ddoi
10.1007/s11255-016-1425-6subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2089-2094issue
12eissn
0301-1623issn
1573-2584pii
10.1007/s11255-016-1425-6journal_volume
48pub_type
杂志文章abstract：PURPOSE:Sleep disturbance is significantly associated with overall morbidity, mortality, and quality of life in end-stage renal disease patients. Although it was reported that the prevalence of poor sleep quality was 41-83% in hemodialysis patients, sleep disturbance was not well understood in peritoneal dialysis (PD) ...
journal_title：International urology and nephrology
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doi：10.1007/s11255-011-0060-5
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journal_title：International urology and nephrology
pub_type： 杂志文章,多中心研究
doi：10.1007/s11255-018-1997-4
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abstract：PURPOSE:Organ-sparing surgery (OSS) for the kidney and adrenals has emerged as the need for preservation of function is paramount in patients with poor functional reserve. As reports increasingly showed that oncological outcomes were equivalent to radical excision, elective OSS became a viable alternative in patients w...
journal_title：International urology and nephrology
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abstract：:The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02549645
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abstract：:Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocel...
journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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doi：10.1007/BF02082706
更新日期：1984-01-01 00:00:00
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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更新日期：2017-04-01 00:00:00
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journal_title：International urology and nephrology
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更新日期：2011-06-01 00:00:00
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journal_title：International urology and nephrology
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doi：10.1007/BF02550307
更新日期：1998-01-01 00:00:00
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journal_title：International urology and nephrology
pub_type： 杂志文章
doi：10.1007/BF02081940
更新日期：1981-01-01 00:00:00
abstract：:Type 2 diabetes mellitus (DM2) is a chronic condition that affects more than 400 million individuals worldwide. In DM2 patients, an appropriate glycemic control slows the onset and delays the progression of all its micro and macrovascular complications. Even though there are several glucose-lowering drugs, only approx...
journal_title：International urology and nephrology
pub_type： 杂志文章,评审
doi：10.1007/s11255-020-02585-w
更新日期：2020-08-07 00:00:00
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journal_title：International urology and nephrology
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：International urology and nephrology
pub_type： 杂志文章,随机对照试验
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更新日期：2018-04-01 00:00:00
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journal_title：International urology and nephrology
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更新日期：2006-01-01 00:00:00
