Abstract:
BACKGROUND:The recent guidelines recommend using the estimated glomerular filtration rate (eGFR) to evaluate renal function. There are two reported full-age-spectrum (FAS) equations in 2017, which are based on serum cystatin C concentrations with or without accompanying serum creatinine level (FASCr-Cys or FASCys). We compared the performance and assessed the applicability of the new FAS equation with the 2012 CKD-EPI (CKD-EPICys and CKD-EPICr-Cys) equation in Chinese subjects. METHODS:A total of 1184 patients, mean aged 55.06 year who underwent 99mTc-DTPA GFR measurements (rGFR) from four hospitals were enrolled. The bias (eGFR-rGFR), precision (interquartile range of difference [IQR]), and accuracy (the proportion of eGFR within 30% of rGFR [P30]) of eGFR and rGFR calculated by four equations were compared. RESULTS:Generally, the equation based on the combination of Cys and Scr performed superior to that on the basis of Cys alone, either the CKD-EPICr-Cys or the FASCr-Cys. Detailedly, referred to rGFR (67.33 ml/min/1.73 m2), the CKD-EPICys, CKD-EPICr-Cys, FASCys, and the FASCr-Cys estimated GFR 56.46 ml/min/1.73 m2, 62.79 ml/min/1.73 m2, 56.45 ml/min/1.73 m2, and 61.04 ml/min/1.73 m2, gave ROCAUC0.944, 0.954, 0.943, and 0.953, respectively. Another comparison as to bias, precision, P30, and RMSE with FASCr-Cys were - 2.87 ml/min/1.73 m2, 19.01 ml/min/1.73 m2, 74.16%, and 17.84 ml/min/1.73 m2 showed that FASCr-Cys performed approximately more accurate than other equations, as well as the diagnostic consistency of GFR staging. In the rGFR < 60 ml/min/1.73 m2 subgroup, the FASCr-Cys equation showed the best performance. In older subjects, compared with FASCys, CKD-EPICr-Cys, and CKD-EPICys, the FASCr-Cys equation had relatively less bias (- 8.09 vs. - 9.63, - 7.52, - 11.04, P < 0.05), most precise (15.18 vs. 16.32, 15.22, 16.63), and most accuracy, P30 was statistically different from the other equations, and achieved a ideal value > 70%. CONCLUSION:The performance of the FASCr-Cys equation is better than that of the CKD-EPICr-Cys equation in the Chinese population, particularly in the elderly. Yet, further modification of FAS equations from a large-scale study could be more suitable for the Chinese population, particularly in older people.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Yong Z,Li F,Pei X,Liu X,Song D,Zhang X,Zhao Wdoi
10.1007/s11255-018-1997-4subject
Has Abstractpub_date
2019-01-01 00:00:00pages
139-146issue
1eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-1997-4journal_volume
51pub_type
杂志文章,多中心研究abstract::Accurate knowledge about the morphology and degree of infiltration of a bladder tumor is an essential prerequisite to correctly plan, and forecast the results of, the treatment of these tumors. Among the radiological investigations double contrast cystography is superior to excretory cystogram or conventional cystogra...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082014
更新日期:1977-01-01 00:00:00
abstract::Retroperitoneal fibrosis is idiopathic in two thirds of cases and is found most commonly as an isolated fibrotic plaque centered over the lumbar spine and entrapping one or both ureters. It has been postulated that fibrosis in the idiopathic cases results from a hypersensitivity reaction to antigens leaking into the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551311
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abstract::We describe and report two cases of bilateral symptomatic ureterocele with calculi in two young adult women. They were successfully managed endoscopically by a transverse meatotomy and stone extraction done bilaterally in a single operative session. The 6th month postoperative voiding cystourethrogram showed no reflux...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1021302827755
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abstract:OBJECTIVE:The present study investigated the inhibitory effects of a novel minimally invasive implanted tibial nerve stimulation device on non-nociceptive bladder reflexes in cats. MATERIALS AND METHODS:A wireless minimally invasive implanted nerve stimulator was implanted adjacent to the left tibial nerve in seven ca...
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abstract::Administration of intravenous iron to supplement erythropoiesis stimulating agents (ESAs) has become a common practice in the management of anemia in patients with end-stage renal disease. Randomized clinical trials of anemia correction in this population have shown more adverse outcomes in CKD and ESRD patients assig...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-011-0028-5
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abstract::The aim of this report is to emphasize the use of methylene staining test and the Nd:YAG laser in the diagnosis and treatment of premalignant lesions and CIS of the bladder. The use of an appropriate solution of methylene blue (0.2% in 0.9 M NaCl for 15 min) permits the staining of premalignant areas and CIS, and thei...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02559739
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abstract::Silicon transfers were examined during haemodialysis (HD) in 120 chronic HD patients who received 5-hour dialyses 3 times a week. Si levels were measured by flameless atomic absorption spectrophotometry. Ultrafiltrable Si levels approximately equalled dialysate Si levels. Serum Si levels before HD significantly increa...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
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doi:10.1007/s11255-020-02578-9
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768241
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abstract::Renal osteodystrophy, a frequent complication of chronic renal failure, is usually assessed by periodic X-rays of bone which are both poorly reproducible and expensive. Seeking a better screening test for osteodystrophy, we evaluated the usefulness of serum alkaline phosphatase as a predictor of bone disease and of hy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085384
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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doi:10.1007/BF02564772
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abstract:PURPOSE:This study aimed to evaluate the association among the expressions of pro- and anti-inflammatory nuclear factors (nuclear factor-kappaB, NF-κB and nuclear erythroid 2-related factor 2, Nrf2) and nutritional status in HD patients. METHODS:This cross-sectional study included eighty-three HD patients. The periphe...
journal_title:International urology and nephrology
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abstract:PURPOSE:To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS:Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL ...
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journal_title:International urology and nephrology
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abstract::In developing countries, renal transplantation is offered to young end-stage renal disease (ESRD) patients, while the older ones face limitations due to higher mortality risk. We retrospectively analyzed 225 patients who underwent renal transplantation from living donors, aged 40-60 years (Group A) and >60 years (Grou...
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,meta分析,评审
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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pub_type: 杂志文章,随机对照试验
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
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journal_title:International urology and nephrology
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