Abstract:
:Sirolimus is an immunosupressor of the mammalian target of rapamycin inhibitors (mTOR-I) group. Recent studies have emphasized a potential impact of sirolimus on male gonadal function. We report our clinical experience with sirolimus-induced gonadal dysfunction and infertility in both male and female kidney transplant patients. Of the 170 kidney transplant patients, nine (5.3%) patients (six males and three females) were receiving sirolimus. Follow-up data for two male patients were not available. The one unmarried female patient developed amenorrhea post-transplantation and had resumption of her menstrual cycles after discontinuation of sirolimus. The remaining six married patients (four males and two females), who all had fathered or conceived children in the pre-transplantation period, developed gonadal dysfunction and infertility on average 5-12 months after transplantation. Sirolimus was discontinued in all four male patients with full recovery of the oligo/azospermia and restoration of fertility. Both married female patients developed amenorrhea post-transplantation. Sirolimus was discontinued in one female patient with resumption of her menstrual cycles. In this small population of patients treated with sirolimus, the prevalence rate of reversible gonadal dysfunction and infertility was significant in both males and females. Infertility secondary to sirolimus is under-diagnosed and should be studied further.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Boobes Y,Bernieh B,Saadi H,Raafat Al Hakim M,Abouchacra Sdoi
10.1007/s11255-009-9644-8subject
Has Abstractpub_date
2010-06-01 00:00:00pages
493-8issue
2eissn
0301-1623issn
1573-2584journal_volume
42pub_type
杂志文章abstract::Methylene blue (MB) alone, MB metabolites in the urine and the effect of MB plus alkalization on Candida species were determined. MB was used for the treatment of childhood renal candidiasis (CRC) in 3 patients as an irrigating solution. Besides irrigation, fluconazole 3 mg/kg/day intravenously and MB 0.2 mg/kg/day we...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550565
更新日期:1998-01-01 00:00:00
abstract::Ureteric stents, a good solution to many urologic problems, can lead to significant morbidity if left in situ longer than required. Our case is that of an elderly male with a history of intractable hypertension presenting with urosepsis, anemia, diabetes and chronic renal failure. His work-up revealed a stent in the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0021-3
更新日期:2005-01-01 00:00:00
abstract::Analysis was performed on the clinical features of children with VUR who had one or two kidneys that were at least -2 SD smaller than normal for age of its renal ratio. The prevalence of the small kidney was 15.6% (97/623 children). Of 107 small kidneys, 87 (82%) were associated with moderate (grade IV) to severe (gra...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549509
更新日期:1988-01-01 00:00:00
abstract::There has been no documentation on the epidemiology of end stage renal disease (ESRD) in the Cayman Islands. We retrospectively surveyed all facilities providing renal replacement therapy in the Cayman Islands in order to define the epidemiology of kidney failure in this setting. The prevalence of ESRD in this populat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9543-z
更新日期:2010-06-01 00:00:00
abstract::During a 3-year period, hundreds of patients underwent ESWL treatment with the Dornier HM-3 and HM-4 lithotriptors operating at our institution. Our experience in 3,500 patients treated with the HM-4 bath-free lithotriptor is reported. Patients with radiolucent or cystine stones, stones larger than 3 cm or staghorn ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551334
更新日期:1997-01-01 00:00:00
abstract:PURPOSE:Studies have shown the increased incidence of urinary tract cancers which are associated with a decrease in glomerular filtration rate (GFR). We hypothesized that patients with GFR < 60 ml/min/1.73 m2 have an increased risk for higher staging and histology grades of cancers and, therefore, the increased risk fo...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02216-z
更新日期:2019-09-01 00:00:00
abstract::The factors of infective calculus formation and the conditions favoring their prevention were studied by examining in vitro the role of the most common representative of urease-producing bacteria, Proteus mirabilis. The stream of Proteus-containing urine was found to form deposits of magnesium ammonium phosphate, carb...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082070
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:We examined the incidence of myocardial ischemia (MI) in kidney transplant recipients (KTR) using myocardial perfusion imaging (MPI), and its association with long-term outcomes after transplantation. METHODS:A retrospective observational study was conducted of asymptomatic KTRs who underwent post-transplant M...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02542-7
更新日期:2020-10-01 00:00:00
abstract::Kidney injury molecule-1 (KIM-1) staining has been shown to be very useful in identifying acute proximal tubular injury, but its sensitivity, specificity and predicting values for the recovery of renal function after injury in renal biopsies have not been well established. In the first study, we randomly selected 184 ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02311-1
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:Metformin has been shown to reduce diabetic complications in overweight patients, and is increasingly used to treat this condition. However, this agent is associated with a rare but serious risk of lactic acidosis. METHODS:From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9549-6
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the new medical device Transurethral Suprapubic endo-Cystostomy (T-SPeC(®)), used for suprapubic catheter (SPC) placement via the transurethral (inside-to-out) approach, and examine the 30-day outcomes in the first US series. METHODS:IRB approval was obtained for this prospective s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0884-x
更新日期:2015-02-01 00:00:00
abstract::The authors describe two cases of urinary infection and stone formation as late complications of Gil-Vernet's antireflux treatment. The immediate cause of these complications was the migration to the mucosal surface of the nonabsorbable sutures employed in this technique. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551296
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:To prospectively compare biopsy outcomes between free-hand transperineal mpMRI/TRUS fusion targeted biopsy (TB) and transperineal systematic biopsy (SB) in patients with first prostate biopsy. PATIENTS AND METHODS:In all, 224 consecutive patients with the suspicion of PCa were investigated. All patients wer...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1484-8
更新日期:2017-03-01 00:00:00
abstract::Gleason score has been identified as an important variable to predict disease extent and biologic behaviour of prostate cancer. However, the correlation between Gleason score of needle biopsy and surgical specimen is often poor. We studied 72 patients who underwent needle biopsy and radical prostatectomy to correlate ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550548
更新日期:1998-01-01 00:00:00
abstract::The recommended treatment for patients with severe bleeding from upper gastrointestinal (GI) metastases is embolisation. We report a case in which despite adequate embolisation major haemorrhage from renal cell carcinoma (RCC) gastric metastases continually recurred. During a severe bleed refractory to embolisation oc...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-0251-z
更新日期:2005-01-01 00:00:00
abstract::In 68 men with benign prostatic hyperplasia, we evaluated the association between obesity and prostatic enlargement, as well as changes in serum levels of oestradiol, testosterone, dihydroepiandrosterone and dihydroepiandrosterone sulphate. Despite the larger adenomas, no increase in the symptom score for BPH was obse...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550138
更新日期:1996-01-01 00:00:00
abstract::Idiopathic Localised Bladder Amyloidosis is a rare cause of haematuria and urinary tract symptoms. A review of the literature highlights the varied presentations and the appropriate investigations for this condition, with emphasise on the exclusion of a secondary cause. In addition, the range of treatment options is f...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1021302827755
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine the usefulness of three GFR-estimating equations (eGFR) compared with measured GFR (mGFR) in potential living kidney donors. METHODS:We compared the performance of the MDRD, CKD-Epi and Cockcroft-Gault equations with mGFR measured using (51)Cr-EDTA in 508 consecutive potent...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0859-y
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:So far, studies have not clearly identified infectious agents as an etiological factor for interstitial cystitis (IC). Specific microbiological diagnosis for detecting the pathogen with higher sensitivity in IC may decrease the treatment costs and increase psychosocial health of the patients. METHODS:A prospec...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02248-5
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:To investigate the effects of combined treatment of tadalafil (a phosphodiesterase-5 inhibitor) and tamsulosin (an α1-adrenoceptor antagonist) on bladder dysfunction in a rat model of bladder outlet obstruction (BOO). METHODS:Cystometry was performed in conscious female BOO rats 6 weeks after partially ligatio...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1835-8
更新日期:2018-05-01 00:00:00
abstract::Among 104 patients with urethral strictures treated over a period of 3 years, sixty-five (63%) had complications such as inflammatory periurethral mass, watering-can perineum with discharging sinuses and fistulas, associated urethral calculi, periurethral abscesses and urethral diverticula. Seventy-four per cent of th...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549587
更新日期:1989-01-01 00:00:00
abstract::Genitourinary organs are at greater risk for multiple primary malignant neoplasms because of the high incidence of these tumours as primaries among all other organs. We present a case of prostate and bladder carcinoma metastasized to a single pelvic lymph node, called a "collision" metastasis, in a patient with four p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552140
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Anaemia and resistance to erythropoiesis-stimulating agents (ESAs) are common complications in haemodialysis (HD) patients. We investigated the role of hepcidin in the development of anaemia and ESA resistance/hyporesponsiveness and its relation to the plasma levels of the inflammatory markers interleukin 6 (IL...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-2062-z
更新日期:2019-02-01 00:00:00
abstract::The advent of new diagnostic procedures has made it possible for urologists to detect chlamydial presence in genital infections. Many studies have shown chlamydial association with urethritis. However, its presence in prostatitis and epididymitis has not been clearly defined yet. In this study we investigated the pres...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549645
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the impact of obesity on clinicopathological features and biochemical recurrence (BCR) following radical prostatectomy (RP) in Korean prostate cancer (PCa) patients. METHODS:A single-institutional retrospective analysis was performed on 880 PCa patients treated by RP ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0729-7
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To evaluate the effect of masturbation on the spontaneous expulsion of distal ureteral stones 5-10 mm in size. MATERIAL AND METHODS:A total of 128 men with distal ureteral stones were randomly divided into 3 groups. All patients received standard medical therapy. Patients in group 1 (n = 43) were instructed to...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02672-y
更新日期:2020-10-07 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of stepwise extracorporeal shock wave lithotripsy in the treatment of upper urinary stones in childhood. PATIENTS AND METHODS:Between August 1998 and August 2003, 31 patients were treated for renal or ureteric stones. All treatments were performed with Dornier Compact Delta lithot...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-005-4971-x
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To compare efficacy, safety, and cost-effectiveness of fosfomycin tromethamine with other standard-of-care antibiotics in patients undergoing ureteroscopic lithotripsy. METHODS:This study was a prospective, multicenter, randomized, controlled trial. Eligible patients scheduled for ureteroscopic lithotripsy wer...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11255-017-1776-7
更新日期:2018-03-01 00:00:00
abstract::Immunoglobulin A nephropathy (IgAN) is an immune-complex-mediated glomerulonephritis characterized by the presence of IgA deposits in mesangial and paramesangial regions. However, the exact mechanism involved in IgA deposition is still unknown. TGF-β(1) that mediates the progression of IgAN is well established as a cr...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9682-2
更新日期:2010-09-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of the calcineurin inhibitors (CNIs) cyclosporine (CyA) and tacrolimus (TAC) in the induction and maintenance treatment of lupus nephritis (LN). METHODS:The Cochrane library, PubMed, Embase, and CENTRAL databases were searched and reviewed up to February 2015. Randomized con...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-015-1201-z
更新日期:2016-05-01 00:00:00