Abstract:
PURPOSE:To evaluate the efficacy and safety of the calcineurin inhibitors (CNIs) cyclosporine (CyA) and tacrolimus (TAC) in the induction and maintenance treatment of lupus nephritis (LN). METHODS:The Cochrane library, PubMed, Embase, and CENTRAL databases were searched and reviewed up to February 2015. Randomized controlled trials were analyzed using RevMan 5.2 software. RESULTS:Ten randomized controlled trials were selected and included in this study according to our inclusion and exclusion criteria, and six were included in the meta-analysis. The analysis results indicated that, in induction treatment, no statistically significant difference was observed in the rates of complete remission (CR), partial remission (PR), or response between the CNIs and intravenous cyclophosphamide (ivCYC). However, the rates of adverse events such as infection (RR 0.65, P = 0.04), leukocytopenia (RR 0.32, P = 0.04), and menstruation disorder (RR 0.37, P = 0.01) following the use of the CNIs were remarkably lower than those after ivCYC. No differences in the CR, PR, infection, or leukocytopenia rates were observed between the CNIs and mycophenolate mofetil (MMF). In the maintenance treatment period, the relapse rate between the CNIs and azathioprine (AZA) was similar (RR 0.44, P = 0.27), while the leukocytopenia rate was lower with the CNIs (RR 0.26, P = 0.0005). CONCLUSION:The efficacy of the CNIs CyA and TAC in induction therapy for lupus nephritis is comparable to ivCYC and MMF, and they are much safer than ivCYC. CNI treatment during the maintenance period was also as effective as AZA treatment, with a much lower risk of adverse effects. The CNIs CyA and TAC should be recommended for both induction and maintenance therapy of LN.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zhang X,Ji L,Yang L,Tang X,Qin Wdoi
10.1007/s11255-015-1201-zsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
731-43issue
5eissn
0301-1623issn
1573-2584pii
10.1007/s11255-015-1201-zjournal_volume
48pub_type
杂志文章,meta分析,评审abstract::Fifty-eight patients with urate calculi and 31 patients with other (non-urate) calculi were examined for total-body potassium by means of a total-body counter. The patients with urate calculosis were found to differ significantly in their total-body K from patients with other calculi as well as from normal subjects. T...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082228
更新日期:1979-01-01 00:00:00
abstract::The activity of the leucocyte inhibitory factor (LIF) stimulated with Concanavalin A was examined in chronic uraemic, haemodialysed patients. It was found that the LIF activity decreased in chronic uraemic patients as compared with the normal controls. The absolute T lymphocyte count and active E rosette formation als...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082475
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is emerging as a predictor of poor stroke outcome, however, it is often not recognized. The aim of our study was to evaluate post-stroke AKI burden, AKI risk factors and their influence in post-stroke outcome. METHODS:From 2013 to 2016, 440 individuals with stroke diagnosis admitte...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02203-4
更新日期:2019-09-01 00:00:00
abstract::In the introduction the author stresses that the main facts which decide the choice and prognosis of therapy are localization, length and the so-called complexity of the stricture. His 15-year material from 388 operations on 290 patients is presented. Circular strictures of the anterior urethra (a total of 135 operati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082106
更新日期:1983-01-01 00:00:00
abstract::The best "treatment" of acute kidney injury (AKI) is prevention. Patients who are at high risk of AKI should have an assessment of their volume status and receive appropriate volume expansion. The most effective type of intravenous fluid remains unclear. Innumerable studies have compared sodium bicarbonate and isotoni...
journal_title:International urology and nephrology
pub_type: 社论,评审
doi:10.1007/s11255-014-0820-0
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Proteinuric renal diseases are often associated with progressive tubulointerstitial fibrosis that usually defines the degree and rate of progression of renal failure. Glomerular filtration of excess albumin, the dominant protein in proteinuria, into proximal tubule could provide the stimulus to induce certai...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9249-z
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:We compared the accuracy of magnetic resonance (MR) urethrography and X-ray urethrography with operative findings for urethral strictures and observed their effects on treatment. MATERIALS AND METHODS:A total of 87 male patients (10-85 years of age) treated from January 2015 to December 2016 were included in t...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02162-w
更新日期:2019-07-01 00:00:00
abstract:AIMS:Sacral neurostimulation (SNS) involves a two-stage procedure to assess outcomes prior to permanent implantation. Stage 1 involves placement of a sacral lead that is externalized and tested for 2 weeks. Stage 2 is the implantation of a pulse generator in responders (≥ 50% improved). This study's purpose was to dete...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9919-8
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To investigate whether an elevated serum uric acid (SUA) level is an independent risk factor for rapid decline in renal function or new-onset chronic kidney disease (CKD) in a Chinese health checkup population. METHODS:A cohort study of 6495 Chinese individuals who underwent health checkups with normal estimat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1732-6
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:According to the concept of integrated care, renal transplantation, peritoneal dialysis (PD), and hemodialysis (HD) should be considered three complementary methods of renal replacement therapy. This study tried to evaluate patient outcomes in three different groups of PD patients, namely primary PD patients...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s11255-011-0068-x
更新日期:2012-08-01 00:00:00
abstract::Primary sclerosing lipogranuloma is an unusual benign condition of the genitalia typically presenting as a painless mass affecting the penis and scrotum. Its importance lies in differentiating it from malignancy to avoid extensive surgery. It is normally treated with total or partial excision. This is the first report...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-8572-5
更新日期:2006-01-01 00:00:00
abstract::Five cases of spontaneous rupture of the renal parenchyma are reported. Two patients had renal cell cancer, one sustained acute purulent pyelonephritis secondary to stone related ureteral obstruction, one suffered from aposthematous pyelonephritis without obstruction, while one had chronic pyelonephritis and a cortica...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02768275
更新日期:1994-01-01 00:00:00
abstract::Authors measured the thickness of the basement membranes of the proximal and distal tubuli in the renal cortex in 20 patients with verified diabetes mellitus. The test group consisted of 20 patients with small abnormalities of glomeruli (or in the range of variable norm), of the same sex and comparable age. Measuremen...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550972
更新日期:1996-01-01 00:00:00
abstract::Crossed renal ectopia and/or asymmetric fused kidney are unusual congenital anomalies. The deformity itself usually produces no symptoms and the clinical presentation generally suggests obstruction and infection. In our series, 10 of 11 patients presented with various vertebral anomalies. A theory of embryogenesis was...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549675
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway. It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2-adrenoreceptor/PKA pathway in the prostate gland. We measured...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0513-0
更新日期:2014-03-01 00:00:00
abstract::Angiomyolipoma with extrarenal involvement is very uncommon. Herein we report a case of angiomyolipoma with lymph node involvement in a 17-year-old female. The diagnosis and treatment of the case is discussed. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1020518315280
更新日期:2001-01-01 00:00:00
abstract::The follow-up study has been performed in 4 male patients with nephrogenic diabetes insipidus lasting for 4 to 15 years. Hydronephrosis or hydroureter appeared to be caused by polyuria with or without urinary tract obstruction. The efficacy of drainage operation is emphasized when polyuria surpasses the transporting a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549772
更新日期:1990-01-01 00:00:00
abstract::Foreign body on penis is usually put himself or by his female partner by adults for sexual gratification and in children as an innocent childish play. We have managed a 10 years shepherd who put on a bark of tree with successful outcome which is not being reported in literature. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017565520257
更新日期:2001-01-01 00:00:00
abstract::To evaluate cancer involvement of internal female genitalia of patients undergoing anterior exenteration for clinically organ confined transitional cell carcinoma of the bladder, and identify potential preoperative risk factors. Charts and anterior exenteration specimens from 54 women with clinically organ confined tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9158-6
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:This study investigated the clinical characteristics and symptomatology of ESRD patients in Jordan taking a multidimensional approach. METHODS:This was a cross-sectional study that included a cohort of 620 patients undergoing maintenance hemodialysis (HD). Data were retrieved via patient survey administration ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02458-2
更新日期:2020-05-01 00:00:00
abstract::Experience in the treatment of urinary bladder cancer based upon observation of 306 cases has been presented. Two hundred and thirteen patients were treated surgically by performing in 151 cases partial cystectomy and in 62 cases total cystectomy. Conservative treatment was applied in 75 patients. In the authors' opin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082168
更新日期:1977-01-01 00:00:00
abstract::Ganglioneuroblastoma is a common type of tumor in children, but is rarely seen in adults. We present here a case of adrenal ganglioneuroblastoma in a 59-year old man. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0851-z
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Peritoneal dialysis (PD) related infections are associated with technique failure and mortality. The aim of this multicentre study was to examine epidemiology, treatment and outcomes of PD-related infections in Poland as well as practice patterns for prevention of these complications in the context of curren...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-2057-9
更新日期:2019-02-01 00:00:00
abstract::Ureteric stents, a good solution to many urologic problems, can lead to significant morbidity if left in situ longer than required. Our case is that of an elderly male with a history of intractable hypertension presenting with urosepsis, anemia, diabetes and chronic renal failure. His work-up revealed a stent in the r...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0021-3
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:The venous thromboembolic events (VTE) incidence is high in nephrotic syndrome (NS). We aimed to assess prospectively the risk of VTE in a large cohort of NS patients and to identify predictive factors for VTE, especially haemostasis-related parameters. METHODS:This is the prospective, observational study cond...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0574-0
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to assess the influence of anemia on the risk of developing contrast-induced nephropathy after percutaneous coronary angioplasty. METHODS:Serum creatinine values were measured before and within 48 h after the administration of contrast agents. Contrast-induced nephropathy (C...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0340-8
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:General and spinal anesthesia are currently in widespread use during transurethral bladder tumor resection. However, local anesthetic methods are claimed to provide sufficient intra-operative analgesia and satisfactory post-operative pain management. We evaluated whether local levobupivacaine infiltration of...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11255-007-9295-6
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine the prostate specific antigen (PSA) population standards of a cluster of Turkish men with no clinical evidence of prostate cancer. PATIENTS AND METHODS:We evaluated PSA values of the men who were living in a well-defined, rural district of Western Anatolia. Two hundred fifty-seven men agreed to ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-7976-y
更新日期:2005-01-01 00:00:00
abstract::The concentrations of prostaglandin E2 (PGE2), sodium, potassium and creatinine were determined in the blood and urine of 50 renal transplant recipients treated with cyclosporine A or azathioprine, as immunosuppressive agents, for at least one year post transplantation. Fourteen healthy subjects served as control grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550640
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Supracostal superior calyceal access has been shown to be the most suitable approach for staghorn calculi, calculi in the upper ureter, and complex inferior calyceal calculi. It is a good choice for direct access for most of the intrarenal collecting system and upper ureter. The aim of this retrospective stud...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9916-y
更新日期:2011-12-01 00:00:00