Abstract:
BACKGROUND:Proteinuric renal diseases are often associated with progressive tubulointerstitial fibrosis that usually defines the degree and rate of progression of renal failure. Glomerular filtration of excess albumin, the dominant protein in proteinuria, into proximal tubule could provide the stimulus to induce certain fibrogenic cytokines from proximal tubular cells (PTC), which may account for fibrosis in the interstitium. To explore this hypothesis we tested the effect of bovine albumin in PTC in culture on the expression and secretion of transforming growth factor (TGF) beta-1, a prominent fibrogenic cytokine. METHODS:TGFbeta-1 expressed by cultured PTC was measured by enzyme-linked immunosorbent assay (ELISA) and indirectly by reverse-transcription polymerase chain reaction (RT-PCR). Relative messenger ribonucleic acid (mRNA) levels were measured in ethidium bromides stained gels, by comparison to transcripts for 18s ribosomal RNA. Activated mitogen-activated protein (MAP) kinase was estimated by Western blot with phosphotyrosine-specific antibody. RESULTS:Following incubation of PTC with albumin determination of TGF beta-1 mRNA in PTC and TGF beta-protein in culture medium both indicated a time- and dose-dependent increase. MAP kinase (p44/42) was activated within 5 min of exposure to albumin. Inhibition of the MAP kinase cascade by PD98059 attenuated the effect of albumin on TGF beta-1 expression. CONCLUSIONS:These observations suggest that overexpression of TGF beta-1 by PTC in response to albumin is regulated through a MAP kinase signaling pathway. This mechanism may play a role in the development of interstitial fibrosis in proteinuric states.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zhao J,Tramontano A,Makker SPdoi
10.1007/s11255-007-9249-zsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
1265-71issue
4eissn
0301-1623issn
1573-2584journal_volume
39pub_type
杂志文章abstract:PURPOSE:To compare the performance of prostate-specific antigen (PSA) density in the diagnosis of prostate cancer in obese and non-obese Chinese men. METHODS:The results of transrectal ultrasound-guided (TRUS) prostate biopsies of Chinese men with PSA <20 ng/mL were reviewed. Parameters including age, body mass index ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0826-7
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Glomerular hyperfiltration commonly associated with obesity is expected to improve postbariatric surgery. However, formula-based glomerular filtration rate (GFR) estimation in these patients is limited by body size confounders necessitating use of modified equations, the reliability of which remains uncertai...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0131-2
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The use of anabolic steroids and vitamin supplements has reached alarming proportions in the last decades. Adverse effects have been documented and include virilization, feminization, adverse lipid profile, psychiatric disorders, cardiac and liver disease. Acute kidney injury (AKI) is not frequently describe...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-009-9571-8
更新日期:2009-01-01 00:00:00
abstract::The best "treatment" of acute kidney injury (AKI) is prevention. Patients who are at high risk of AKI should have an assessment of their volume status and receive appropriate volume expansion. The most effective type of intravenous fluid remains unclear. Innumerable studies have compared sodium bicarbonate and isotoni...
journal_title:International urology and nephrology
pub_type: 社论,评审
doi:10.1007/s11255-014-0820-0
更新日期:2015-02-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0670-9
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abstract:BACKGROUND:The aim of the study was to evaluate the impact of magnesium (Mg) on the evolution of arterial calcifications in hemodialysis patients. PATIENTS AND METHODS:Seventy-two stable hemodialysis patients were randomly allocated to two groups: 36 administered a regimen containing magnesium carbonate plus calcium a...
journal_title:International urology and nephrology
pub_type: 杂志文章,随机对照试验
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更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Uremic pruritus (UP) is a highly prevalent and disturbing problem in patients with advanced chronic kidney disease (CKD); however, treatment of UP is largely unsatisfactory. The present study was designed to investigate the effectiveness of mirtazapine, an atypical antidepressant agent with potent antagonist...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
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doi:10.1007/s11255-019-02311-1
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abstract::Administration of intravenous iron to supplement erythropoiesis stimulating agents (ESAs) has become a common practice in the management of anemia in patients with end-stage renal disease. Randomized clinical trials of anemia correction in this population have shown more adverse outcomes in CKD and ESRD patients assig...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2012-04-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9402-3
更新日期:2009-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
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doi:10.1007/s11255-006-6657-4
更新日期:2006-01-01 00:00:00
abstract::Infertility may occur in patients with unilateral testicular torsion whose contralateral testis is intact. Depending on this observation, the physicians have begun to examine the contralateral testis. In the present prospective study we aimed to examine the histopathologic alterations occurring in the contralateral te...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550935
更新日期:1997-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019554327341
更新日期:2001-01-01 00:00:00
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journal_title:International urology and nephrology
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doi:10.1007/s11255-012-0263-4
更新日期:2013-04-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-1188-5
更新日期:2016-03-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02084115
更新日期:1986-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550640
更新日期:1992-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564853
更新日期:1998-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081813
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:Factors responsible for the low incidence of clinical prostate cancer (3-8/100,000 men/year) in the Arab population remain unclear, but may be related to changes in steroid hormone metabolism. We compared the levels of serum conjugated and unconjugated steroids between Arab and Caucasian populations, to de...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3619-1
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Recently, there have been a few reports on the decrease in the incidence of severe Henoch-Schönlein purpura nephritis (HSPN) in Japan. To evaluate the incidence and the severity of HSPN, we examined the epidemiology and clinical manifestations of HSPN in Fukushima Prefecture over a 22-year period. METHODS:W...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9701-3
更新日期:2010-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034631.03070.9c
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:The purpose of the study was to evaluate the diagnostic accuracy of core biopsy in small renal masses ≤ 4 cm in response to the rising prevalence of renal masses. METHODS:Data from 129 consecutive patients who underwent biopsies of solid renal masses of ≤ 4 cm were prospectively collected between September 201...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1885-y
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to assess the feasibility of robotic assisted kidney transplantation in graft with multiple vessels. MATERIALS AND METHODS:Eighteen patients underwent RAKT with grafts with multiple vessels (GMVs) from living donor performed by a single surgeon in single institution. The retrospe...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02305-z
更新日期:2020-02-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1466-x
更新日期:2017-01-01 00:00:00
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journal_title:International urology and nephrology
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更新日期:2017-12-01 00:00:00
abstract::Leptospirosis is an infectious disease caused by pathogenic leptospires and is characterized by a broad spectrum of clinical manifestations, varying from inappearent infection to fulminant, fetal disease. Eighty-five to 90% of leptospirosis infections are self-limiting. However, 5-10% of infection by L. interrogans ca...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1014494012062
更新日期:2002-01-01 00:00:00