Abstract：
:Leptospirosis is an infectious disease caused by pathogenic leptospires and is characterized by a broad spectrum of clinical manifestations, varying from inappearent infection to fulminant, fetal disease. Eighty-five to 90% of leptospirosis infections are self-limiting. However, 5-10% of infection by L. interrogans can cause renal tubular damage, microvascular injury, acute renal failure (ARF), and interstitial nephritis. We studied 36 patients with leptospirosis. Twenty-seven (65%) cases of 36 patients had ARF. Fourteen (51%) had nonoliguric ARF. In thirteen (48%) oliguria appeared on the third or fourth days of hospitalization. Serum BUN, creatinine, serum bilirubine, ALT, AST, potassium and thrombocytopenia levels were higher in oliguric than nonoliguric patients (p < 0.05). However, serum sodium, CPK levels were not different between oliguric and nonoliguric groups (p > 0.05). Thirteen patients (48%) needed in renal replacement therapy (RRT). 8 of them were treated by hemodialysis (HD) alone and 5 patients by HD in combination with hemoperfusion. Twenty-five patients (92%) recovered completely after 3-5 weeks. Two patients (7.4%) who had severe hepatorenal and hemorrhagic syndromes, died. We concluded that till now leptospirosis is actual problem for nephrologist in the developing countries because of very high percentage of renal disease, with good prognosis in patients without multiorgan failure and early treatment.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Cengiz K,Sahan C,Sünbül M,Leblebicioğlu H,Cüner Edoi
10.1023/a:1014494012062keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
133-6issue
1eissn
0301-1623issn
1573-2584journal_volume
33pub_type
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
pub_type： 杂志文章,评审
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