Abstract：
PURPOSE:To compare the performance of prostate-specific antigen (PSA) density in the diagnosis of prostate cancer in obese and non-obese Chinese men. METHODS:The results of transrectal ultrasound-guided (TRUS) prostate biopsies of Chinese men with PSA <20 ng/mL were reviewed. Parameters including age, body mass index (BMI), TRUS prostate volume, and TRUS biopsy results were recorded. The diagnostic yields of PSA density (>0.15 ng/mL as positive) in obese and non-obese men with PSA <20 ng/mL were compared. Obesity was defined as BMI ≥ 27 kg/m(2) according to WHO recommendation for Hong Kong Chinese. RESULTS:TRUS biopsy, BMI, and PSA density data were available for 854 men (mean age 65.9 ± 7.3). The mean PSA values for the obese and non-obese patients were 7.9 ± 3.7 and 8.2 ± 4.1 ng/mL, respectively (p = 0.416). TRUS volumes in obese and non-obese men were 63.2 ml and 51.6 ml, respectively (t test, p < 0.001), and PSA density was significantly lower in obese men (0.145 vs. 0.188, p < 0.001). For obese men, positive PSA density was associated with four times (41.1 vs. 9.5 %, p < 0.001) the risk of prostate cancer, compared to only twice the risk (18.8 vs. 9.7 %, p = 0.001) in non-obese men. The specificity and area under the curve of PSA density were 74.2 % and 0.731, respectively, for obese men, and 51.4 % and 0.653, respectively, for non-obese men. Among patients with a diagnosis of prostate cancer, the obese patient group had a significantly higher proportion of patients with Gleason 7-10 prostate cancer than the non-obese patient group (48.9 vs. 32.7 %, Chi-square test, p = 0.035), and a trend toward a higher proportion of bilateral lobe involvement. CONCLUSION:PSA density had better performance in obese men. Positive PSA density in obese men was associated with four times the risk of prostate cancer.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Chiu PK,Teoh JY,Chan SY,Chu PS,Man CW,Hou SM,Ng CFdoi
10.1007/s11255-014-0826-7subject
Has Abstractpub_date
2014-12-01 00:00:00pages
2251-4issue
12eissn
0301-1623issn
1573-2584journal_volume
46pub_type
杂志文章abstract：PURPOSE:The current study was conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on glycemic control and markers of lipid profiles risk in diabetic hemodialysis (HD) patients. METHODS:This randomized, double blind, placebo-controlled clinical trial was performed among 60 diabetic HD patients. S...
journal_title：International urology and nephrology
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abstract：:A clinical study was designed to investigate whether extracorporeal shock waves altered the urinary excretion of glycosaminoglycans and if they have a diagnostic value in determining the extent of the renal tissue damage. A total of 25 consecutive patients were treated for renal stone by extracorporeal shock wave lith...
journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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abstract：PURPOSE:To evaluate the possible association between metabolic syndrome (MetS) and infectious complications after prostate biopsy. METHODS:A total of 480 men underwent prostatic biopsy due to elevated prostate-specific antigen levels and/or abnormal digital rectal examination. Patients were divided into two subgroups ...
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
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journal_title：International urology and nephrology
pub_type： 杂志文章,随机对照试验
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