Abstract:
PURPOSE:Anaemia and resistance to erythropoiesis-stimulating agents (ESAs) are common complications in haemodialysis (HD) patients. We investigated the role of hepcidin in the development of anaemia and ESA resistance/hyporesponsiveness and its relation to the plasma levels of the inflammatory markers interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP). METHODS:This study included 60 maintenance HD patients attending Ain Shams University Hospital and 30 age- and sex-matched healthy subjects as a control group. Serum hepcidin, IL-6, hsCRP and haemoglobin (Hb) levels were measured in all subjects. The erythropoietin resistance index (ERI) was calculated in the patient group only. RESULTS:There was a significant difference between the patients and controls; the patients had higher hepcidin, IL-6, and hsCRP levels and a lower Hb level. Patients were classified according to their response to ESAs into responder and non-responder groups. Those in the non-responder group had higher hepcidin, IL-6, and hsCRP levels, a higher ERI, and a lower Hb level. Hepcidin showed a positive correlation with IL-6 and hsCRP but a negative correlation with Hb. Upon performing a ROC curve analysis, a cut-off of ≥ 280 ng/ml for hepcidin and ≥ 7.5 for ERI was able to discriminate the responder and non-responder groups with a prognostic accuracy of 83% and 77.3%, respectively. In addition, upon classifying the patients into tertiles according to the ERI, hepcidin significantly increased with increasing ERI. CONCLUSION:Our findings demonstrate an association between the hepcidin level, anaemia and ESA resistance/hyporesponsiveness in HD patients, suggesting its possible role as a candidate marker for ESA resistance.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
El Sewefy DA,Farweez BA,Behairy MA,Yassin NRdoi
10.1007/s11255-018-2062-zsubject
Has Abstractpub_date
2019-02-01 00:00:00pages
325-334issue
2eissn
0301-1623issn
1573-2584pii
10.1007/s11255-018-2062-zjournal_volume
51pub_type
杂志文章abstract::The concentrations of prostaglandin E2 (PGE2), sodium, potassium and creatinine were determined in the blood and urine of 50 renal transplant recipients treated with cyclosporine A or azathioprine, as immunosuppressive agents, for at least one year post transplantation. Fourteen healthy subjects served as control grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550640
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Erectile dysfunction (ED) is one of the most encountered male health problem and sildenafil citrate is used worldwide for treatment of ED. Aim of the present study was to determine and evaluate hemodynamic effects of sildenafil citrate on segmental branches of bilateral renal arteries of cases with ED. PA...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-3621-7
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:According to the concept of integrated care, renal transplantation, peritoneal dialysis (PD), and hemodialysis (HD) should be considered three complementary methods of renal replacement therapy. This study tried to evaluate patient outcomes in three different groups of PD patients, namely primary PD patients...
journal_title:International urology and nephrology
pub_type: 杂志文章,多中心研究
doi:10.1007/s11255-011-0068-x
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To determine the effectiveness of Vacuum-Assisted Closure Device in the postoperative wound care for Fournier's gangrene METHODS: We performed a systematic review in the following databases: Medline (Ovid), EMBASE, and The Cochrane Central Register of Controlled Trials (CENTRAL), from inception to nowadays. We ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02705-6
更新日期:2020-11-13 00:00:00
abstract::We are presenting a 68-year-old female patient who was diagnosed to have a complete ureteral duplication and adenocarcinoma in the ureter which drained the upper moiety of the right kidney. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000025627.15113.e3
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:It is unclear whether any significant changes in the epidemiology of chronic kidney disease (CKD), possibly resulting from the exceedingly rapid economic development and the aggressive prevention and treatment of kidney diseases in the Chinese population, have occurred over the past two decades. METHODS:The...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0194-0
更新日期:2012-08-01 00:00:00
abstract::The long-term results of microsurgical shunts for idiopathic varicocele are reported in the present paper. Sixty-two patients with a total of 65 varicoceles (three were bilateral) were followed up for 1 to 8 years. Pre- and postoperative ultrasonographic evaluation of varicocele size was considered of great importance...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02551419
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Bladder neck contracture (BNC) following prostatectomy has been reported in 0.5-32% of cases. While the etiology of a BNC is unclear, several factors have been associated with this complication, including blood loss, devascularization of bladder neck tissue, poor mucosal apposition and urinary extravasation....
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9239-1
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To compare the performance of prostate-specific antigen (PSA) density in the diagnosis of prostate cancer in obese and non-obese Chinese men. METHODS:The results of transrectal ultrasound-guided (TRUS) prostate biopsies of Chinese men with PSA <20 ng/mL were reviewed. Parameters including age, body mass index ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0826-7
更新日期:2014-12-01 00:00:00
abstract::A 75-year old man with long-term arterial hypertension was diagnosed in 1998 with stage 3 chronic kidney disease due to hypertensive nephropathy. Since May 2004 the patient has been treated with intermittent hemodialysis. Since 1998 he has been hospitalized several times because of palpitations in the course of paroxy...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9302-y
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The growth of solid tumors requires angiogenesis. Evidence indicates that mast cells (MCs) play an important role in tumor angiogenesis but results are not definitive. The aim of this study is to investigate the possible effects of angiogenesis and the presence of MCs on the prognosis of renal cell carcinoma ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-009-9577-2
更新日期:2010-03-01 00:00:00
abstract::Sixty patients in Stages I and II of benign prostatic hyperplasia were treated with Peponen capsule. Out of them 26 took the drug for 10 months, 22 for at least 7, and 12 for at least 4 months. The daily dosage was 3 x 2 capsules in the first month and 3 x 1 capsule for the rest of the time. On the ground of urodynami...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549728
更新日期:1991-01-01 00:00:00
abstract::Infertility in a large proportion of infertile couples is due, in part, to the male factor. Spermatozoa must survive the unique environment of the female reproductive tract in their path to fertilize the ovum. This fact is even more problematic for men with oligospermia. Of the many environmental factors that effect s...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9493-x
更新日期:2009-01-01 00:00:00
abstract::Orthostatic hypotension is very common in the elderly. It increases morbidity and is an independant predictor of all cause mortality. It is defined as a fall in systolic blood pressure greater than 20 mm Hg or a fall in diastolic blood pressure greater than 10 mm Hg within 3 minutes of standing. Symptoms include light...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-005-7663-7
更新日期:2005-01-01 00:00:00
abstract::A case of Itai-itai (ouch-ouch) disease with reduced urinary kallikrein excretion and slightly enhanced renin-angiotensin-aldosterone system is described. Although it is well known that cadmium toxicity frequently affects the renal tubular lesions, this report is the first to demonstrate the impaired urine concentrati...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550809
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:We aimed to investigate significance of smoking regarding pathologic and biochemical outcomes following radical prostatectomy (RP). MATERIALS AND METHODS:We reviewed data of 1,165 patients who underwent RP without any neoadjuvant or adjuvant therapy at our institution. Patients were categorized into two grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9964-3
更新日期:2012-02-01 00:00:00
abstract::In the management of infertility, in case semen quality is found insufficient and could not be improved by medical means, handling the available spermatozoa in the most beneficial way has been aimed. Thus, artificial insemination with low quality semen has become a therapeutic alternative. In this study homologous art...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550148
更新日期:1996-01-01 00:00:00
abstract::Testicular blood flows during unilateral testicular torsion were measured by Xenon-133 clearance technique. Xenon-133 was injected via the left carotid artery into the heart. Measurements were performed in control and left-sided testicular torsion groups, each consisting of ten rats. Left and right testicular blood fl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550119
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Chronic kidney disease (CKD) has been identified as a growing global burden and traditional health care systems are inadequate for the management of CKD patients. This paper describes an initiative to establish a renal management clinic (RMC) in China and discusses the challenges and opportunities in the man...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9450-8
更新日期:2008-01-01 00:00:00
abstract::Experience in the treatment of urinary bladder cancer based upon observation of 306 cases has been presented. Two hundred and thirteen patients were treated surgically by performing in 151 cases partial cystectomy and in 62 cases total cystectomy. Conservative treatment was applied in 75 patients. In the authors' opin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082168
更新日期:1977-01-01 00:00:00
abstract::Multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma are uncommon diseases. We report on 2 cases of multiloculated renal cell carcinoma. To our knowledge 16 cases of multiloculated renal cell carcinoma and multilocular renal cyst with renal cell carcinoma have been previously descr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02583984
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Contrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-018-1814-0
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Estimation of the glomerular filtration rate (GFR) is required in the assessment of patients with chronic kidney disease (CKD) in order to provide information regarding the functional status of the kidneys. Current guidelines advocate the use of prediction equations, such as the Cockcroft-Gault (CG) formula ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9515-8
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of masturbation on the spontaneous expulsion of distal ureteral stones 5-10 mm in size. MATERIAL AND METHODS:A total of 128 men with distal ureteral stones were randomly divided into 3 groups. All patients received standard medical therapy. Patients in group 1 (n = 43) were instructed to...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02672-y
更新日期:2020-10-07 00:00:00
abstract:PURPOSE:To investigate whether an elevated serum uric acid (SUA) level is an independent risk factor for rapid decline in renal function or new-onset chronic kidney disease (CKD) in a Chinese health checkup population. METHODS:A cohort study of 6495 Chinese individuals who underwent health checkups with normal estimat...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1732-6
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:Previous studies on the association between extracorporeal shock wave lithotripsy (SWL) and new onset hypertension have only illustrated contradictory results. In order to illustrate the association between SWL and new onset hypertension, a meta-analysis of case-control and cohort studies was conducted. METH...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-013-0588-7
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Water intake is important for preventing kidney stones. Small molecules water is a more active restructured water under magnetic field. Here, we studied the relation between small molecules water and crystal formation in the rat kidney. MATERIALS:The small molecules water was prepared by a water machine provid...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1769-6
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:The objective of the present study is to analyze long-term testicular cancer (TC) survivors focusing on the correlation of therapeutic modalities used, the age of patients and second malignancy (SM) occurrence. PATIENTS AND METHODS:A total of 1,367 patients with TC and different subsequent therapeutic procedur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0554-4
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of stepwise extracorporeal shock wave lithotripsy in the treatment of upper urinary stones in childhood. PATIENTS AND METHODS:Between August 1998 and August 2003, 31 patients were treated for renal or ureteric stones. All treatments were performed with Dornier Compact Delta lithot...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
doi:10.1007/s11255-005-4971-x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Neutrophil to lymphocyte ratio (NLR) is widely used as a marker of inflammation and an indicator of cardiovascular outcomes in patients with coronary artery disease. However, its prognostic value in peritoneal dialysis (PD) patients is still unknown. METHODS:We studied 138 newly started PD patients and 60 h...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0130-3
更新日期:2012-10-01 00:00:00