Abstract:
:Immunoglobulin A nephropathy (IgAN) is an immune-complex-mediated glomerulonephritis characterized by the presence of IgA deposits in mesangial and paramesangial regions. However, the exact mechanism involved in IgA deposition is still unknown. TGF-β(1) that mediates the progression of IgAN is well established as a critical IgA class (isotype) switching factor, and Smad proteins are critical intracellular mediators in the expression of TGF-β(1)-targeted genes, which suggest that TGF-β signaling has been implicated in the primary pathogenesis of IgAN. Arkadia, an E3 ubiquitin ligase, can amplify TGF-β signaling through regulating Smads degradation. When these findings are considered together, it is of interest to explore how Arkadia and Smad signaling affect TGF-β(1)-induced IgA expression in IgAN. Therefore, we propose that Arkadia could positively contribute to TGF-β(1)-induced IgA secretion through up-regulation of Smad signaling in the pathogenesis of IgAN.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Li XZ,Feng JT,Hu CP,Chen ZQdoi
10.1007/s11255-009-9682-2subject
Has Abstractpub_date
2010-09-01 00:00:00pages
719-22issue
3eissn
0301-1623issn
1573-2584journal_volume
42pub_type
杂志文章,评审abstract::When groups of 10 Spontaneously Hypertensive Rats (SHR) were fed diets containing either 1% w/w regular garlic (Allium sativum) (AS) or 1% w/w wild garlic (Allium ursinum) (AU) for 45 days, the final mean systolic blood pressure (SBP) was reduced significantly compared to control (C) (C 189; AS 175; Au 173 mm Hg). Com...
journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
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abstract::Behcet's disease (BD) is a rare chronic, relapsing, multisystemic disorder characterized by mucocutaneous, ocular, vascular and central nervous system manifestations. However, the etiopathogenesis of the disease remains unknown, and diagnosis is basically dependent on clinical manifestations. Sometimes BD may be diagn...
journal_title:International urology and nephrology
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doi:10.1007/s11255-013-0519-7
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journal_title:International urology and nephrology
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abstract::Primary squamous cell carcinoma of seminal vesicle is extremely rare, and most cases regarding seminal vesicle tumors failed to address this kind of tumor. A 54-year-old male patient presented with intermittent painless visual hematuria for 6 months was hospitalized. Ultrasonography, computerized tomography and magnet...
journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007104326689
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085428
更新日期:1975-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9416-x
更新日期:2009-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-9027-3
更新日期:2007-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549869
更新日期:1987-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02755-w
更新日期:2021-01-16 00:00:00
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journal_title:International urology and nephrology
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025679205541
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD). METHODS:In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovot...
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doi:10.1007/s11255-018-2058-8
更新日期:2019-03-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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journal_title:International urology and nephrology
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pub_type: 杂志文章,meta分析,评审
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pub_type: 社论,评审
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000032671.74121.d3
更新日期:2004-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1484-8
更新日期:2017-03-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:International urology and nephrology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00